Clinical Presentation and Diagnosis of Endometriosis

Galle, Phillip C.

doi:10.1016/s0889-8545(21)00136-4

Cited by 53 publications

(8 citation statements)

References 52 publications

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“…RE-β is a potential target of treatment in the future, and more diseases will initiate RE-α. Control of RE-β will be an alternative management for endometriosis [33,34].…”

Section: Discussionmentioning

confidence: 99%

Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis

Sutrisno

Destikatari

2023

a-jhr

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Introduction: Endometriosis is the endometrial tissue proliferation outside the uterine space. Anti-angiogenic agents from different groups of substances are currently being discussed as promising therapies for the treatment of endometriosis in the future, one of which is therapy using the phytoestrogen genistein. At the molecular level, genistein's effects on cells include inhibition of proliferation, induction of differentiation, apoptosis, and cell arrest in the cell cycle, which are related to the transforming growth factor. Genistein inhibits cell growth by modulating the signal-transforming growth factor pathway. Methods: We searched PubMed, Scopus, Cochrane Library and Proquest from its inception to December 2022 to collect observational and interventional studies of Genistein consumption in endometriosis mice. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Safety analysis was assessed through TNF-α and IL-6 values of estrogen expression. Results: No significant difference in the values of IL-6 and TNF-α in rats with endometriosis that were given genistein at these three doses. However, if analyzed further, the IL-6 outcome compared to the 0.78mg/day dose most affected the IL-6 value between the two groups, and the TNF-α output compared to the 0.78 mg/day dose most affected the TNF-α value between the two groups. So, a genistein dose of 0.78 mg/day can affect IL-6 and TNF-α in mice with endometriosis. Conclusion: Genistein modulated estrogen expression of TNF-α and IL-6 at all doses, but the best dose for its effect was 0.78 mg/day.

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“…RE-β is a potential target of treatment in the future, and more diseases will initiate RE-α. Control of RE-β will be an alternative management for endometriosis [33,34].…”

Section: Discussionmentioning

confidence: 99%

Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis

Sutrisno

Destikatari

2023

a-jhr

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“…Endometriosis was found in 19% of women with persistent pelvic discomfort at the point of surgery [ 37 , 38 ]. Dysmenorrhea, intermenstrual discomfort, and dyspareunia are common symptoms of pelvic pain.…”

Section: Reviewmentioning

confidence: 99%

Endometriosis: A Review of Clinical Diagnosis, Treatment, and Pathogenesis

Chauhan¹,

More²,

Chauhan³

et al. 2022

Cureus

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Endometriosis is a condition that affects women of reproductive age, and it is distinguished by the development of endometrial-like tissue outside the uterine cavity. It is frequently accompanied by persistent pelvic discomfort and infertility. This investigation looks into recent findings on clinical manifestation to help doctors and improve women's health. PubMed and Google Scholar were used to review on clinical diagnosis of endometriosis. The search strategy contained the terms "endometriosis" and "clinical diagnosis." All research articles published between 1960 and 2021 were included in the search. The findings were then categorized to summarize the evidence. There was a total of 29 instances of endometriosis discovered. The patients' ages varied from 20 to 45 years old, with a median of 28.8 years and a mean of 29.4±7.7 years. Dysmenorrhea is a common disorder among adolescent girls experiencing various physical and emotional symptoms which have a detrimental influence on their quality of life. In this study, scar endometriosis was shown to be the more common variety of endometriosis, with 50% of cases predominantly developing at the lower segment cesarean section (LSCS) scar site. As a result, women with endometriosis are more likely to have miscarriages, and the quality of their embryos declines as a result.

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“…Endometriosis is a chronic, benign and estrogen-dependent pro-inflammatory gynecological disease, which is characterized by the presence of endometrial tissues, consisting of functional endometrial glands and stromal at anatomic sites outside the uterine cavity, especially the pelvic peritoneum and ovaries (7)(8)(9).…”

Section: Endometriosismentioning

confidence: 99%

“…Tenderness on palpation of the posterior fornix is the most common finding. Pelvic pain is also a symptom of other diseases such as pelvic adhesions, adenomyosis, and gastrointestinal or urologic disorders; therefore, differential diagnosis is important (7). Other causes of pelvic pain should be ruled out by carrying out appropriate diagnostic tests like urinalysis, Pap smear, pregnancy test, vaginal and endocervical swabs.…”

Section: Diagnosismentioning

confidence: 99%

Endometriosis diagnosis and medical treatment: Present and future

Núñez-Troconis

2021

Gaceta Médica De Caracas

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The objective was to review the different diagnostic methods and medical treatments for endometriosis. It was reviewed the Latin-American and international bibliography using the Pub-Med, Google Scholar, Springer, the Cochrane Library, Embase, Scielo, Imbiomed-L, Redalyc, and Latindex websites. The searches included the keywords: endometriosis, endometriotic, endometrial and ectopic endometrium, angiogenesis, angiogenesis and endometriosis, endometriosis, and medical treatment, endometriosis, and new treatment.

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Clinical Presentation and Diagnosis of Endometriosis

Cited by 53 publications

References 52 publications

Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis

Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis

Endometriosis: A Review of Clinical Diagnosis, Treatment, and Pathogenesis

Endometriosis diagnosis and medical treatment: Present and future

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