Clinical Presentation

Fayadh, Rafid

doi:10.5772/54362

Cited by 2 publications

(2 citation statements)

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“…The electrocardiogram usually demonstrates normal sinus or sinus tachycardia rhythm, but frequent ectopy and other atrial arrhythmias may also be present. Left ventricular hypertrophy, inverted T waves, Q waves, and nonspecific ST-T changes have also been reported [215]. Recurrence in a subsequent pregnancy has been reported.…”

Section: Peripartum Cardiomyopathymentioning

confidence: 95%

“…It is identified by the presence of multinucleated giant cells associated with eosinophils and myocyte destruction in the absence of granulomas on endomyocardial biopsy. It is thought to be primarily autoimmune in nature because of the reported comorbidity with a variety of autoimmune disorders [188], thymoma [189], and drug hypersensitivity [190]. Idiopathic giant cell myocarditis is usually a fulminant form of myocarditis, characterised by a history of rapid progression of severe heart failure associated with refractory sustained ventricular arrhythmias.…”

Section: Giant Cell Myocarditismentioning

confidence: 99%

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Diagnosis and Treatment of Myocarditis

Milei¹,

Ambrosio²

2013

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His thesis about the effects of isoproterenol on myocardium was published in Am Heart J in 1976 and has been extensively cited as well as his investigations in the '80 in NIH, National Heart, Lung and Blood Institute, USA under the guidance of his mentor, Victor Ferrans. As a member of the Argentine Society of Cardiology from 1975, he has developed an extensive societary activity. Professor Milei is the Chairman of the Module of Cardiology and Hypertension at the Argentine Medical Association devoted to South American general practitioners´ training. His research on Chagas' cardiomyopathy substantially contributed to the knowledge of its pathophysiology and his work on early atherosclerotic lesions helped set up the basis for the importance of intimal thickenings in plaque genesis. He has authored over 140 papers in peer reviewed journals, 4 books and over 10 invited chapters in books on cardiology. He is a scientific advisor to the University of Buenos Aires and the Director of the Doctoral Department of the Northwest University in Argentina. His work on Chagas' disease has been a reference book in the last 20 years.

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Section: Peripartum Cardiomyopathymentioning

confidence: 95%

Section: Giant Cell Myocarditismentioning

confidence: 99%

Diagnosis and Treatment of Myocarditis

Milei¹,

Ambrosio²

2013

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Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

Vedam

Ghanta

Kantipudi

et al. 2022

Journal of Pharmacology and Pharmacotherapeutics

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Background: There is an increasing need for proactive and individualized responses to various diseases in today’s progressive health-care fraternity. Accordingly, the approach to schizophrenia patients encompasses novel developments in the area of personalized medicine. Antipsychotic drugs in clinical practice necessitate biomarkers for the prediction of treatment outcomes and monitoring to ensure an appropriate choice of duration of chronic therapies. Hence, we studied the relation between homocysteine levels in peripheral blood and the effectiveness as well as the safety of haloperidol and olanzapine in schizophrenia treatment. Materials and Methods: A prospective randomized parallel-group open-label interventional clinical trial was conducted on 40 mild to moderate schizophrenia patients. To compare the efficacy of olanzapine and haloperidol Brief Psychiatric Rating Scale (BPRS) score was used. Homocysteine levels of peripheral blood and Abnormal Involuntary Movement Scale scores were evaluated. Results: BPRS score improved in both groups on day 14 and day 28. But significantly more with olanzapine ( P value =.001). The olanzapine group showed a higher reduction (13.91±0.47 to 9.74±0.5) in homocysteine levels than the haloperidol group. Also, the BPRS scores negatively correlated ( r = –0.66) to homocysteine levels. Conclusion: Therefore, our study shows that peripheral blood homocysteine levels can be used to predict and assess the treatment outcome in schizophrenia patients. Biomarker driven approach in schizophrenia will allow the patients to be treated promptly with the right drug. In this light, personalized treatment holds great potential in the future.

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Clinical Presentation

Cited by 2 publications

References 0 publications

Diagnosis and Treatment of Myocarditis

Diagnosis and Treatment of Myocarditis

Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

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