Clinical predictors of quality of life in a large sample of adult obsessive-compulsive disorder outpatients

Velloso, Patricia; Piccinato, Cinthia; Ferrão, Ygor Arzeno; Perin, Eduardo Aliende; Cesar, R.; Fontenelle, Leonardo F.; Hounie, Ana Gabriela; Rosário, Maria Conceição do

doi:10.1016/j.comppsych.2018.07.007

Cited by 15 publications

(19 citation statements)

References 62 publications

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“…On the other hand, a recent study reported that the QOL measure of Short Form-36 (SF-36) domain scores did not differ among OCD patients according to the age of disease onset. However, illness duration had a significant negative correlation with the SF-36 domains General Health, Bodily Pain, Role-Physical and the Role-Functioning (15). These differences may be due to sampling size and composition, psychometric tools used and the exclusion of comorbid conditions in this study.…”

Section: Discussionmentioning

confidence: 72%

“…The difference between the groups in terms of the environmental domain score was not statistically significant. In a recent study, it was shown that OCD patients had lower scores than healthy controls in all areas of QOL except for the physical health domain score (15). Another study also showed that OCD patients had a QOL in the physical health domain similar to that of healthy controls, whereas they showed worse social functioning and psychological domain scores (30).…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, we found that patients with a history of previous suicide attempt had significantly worse QOL scores in all subscales. In a limited number of studies in the literature, the relationship between some subscales of QOL and suicide attempt has been reported (15). A recent study found that OCD patients with suicidality had significantly lower SF-36 scores, especially in the Mental Health domain, followed by Vitality, General Health, Role-Emotional, Social Functioning, and Bodily Pain.…”

Section: Discussionmentioning

confidence: 99%

“…Although thought to be a rare entity in OCD patients, more recent studies have found that suicidal behavior is much more common in these patients than had been claimed before (13,14). To date, few studies reported a significant association between suicide and a worse QOL in this population (12,15). On the other hand, poor insight has been reported in 15 to 36.0% of patients with OCD, and it has been suggested that this correlation might be associated with a specific clinical subtype that is characterized by an early onset, a greater severity of psychopathology, a higher comorbidity with schizotypal personality disorder, and an insufficient response to both pharmacological and psychological therapies (16)(17)(18).…”

Section: Introductionmentioning

confidence: 92%

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Relation of quality of life with clinical and demographic features in patients with obsessive-compulsive disorder: the effect of insight and suicidality

Ekinci¹

2020

Dusunen Adam

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

See 2 more Smart Citations

Relation of quality of life with clinical and demographic features in patients with obsessive-compulsive disorder: the effect of insight and suicidality

Ekinci¹

2020

Dusunen Adam

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“…Indeed, various longitudinal treatment studies indicate that OCD symptom reduction is not or only weakly related to QoL improvement [16,21,24] and to improvement of depressive symptoms [23]. Cross-sectional studies examining the factors associated with QoL in OCD report a variety of factors to impact on QoL in OCD patients, including older age, female sex, unemployment, contamination, hoarding and symmetry symptom dimensions, over-responsibility for harm, comorbid anxiety and depression symptoms, low social status, and perceived low social support [15,16,[25][26][27][28][29][30]. However, due to the cross-sectional design of these studies, causal inferences cannot be made.…”

Section: Introductionmentioning

confidence: 99%

Four-year course of quality of life and obsessive–compulsive disorder

Remmerswaal

Batelaan

Hoogendoorn

et al. 2019

Soc Psychiatry Psychiatr Epidemiol

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Objective Patients with obsessive compulsive disorder (OCD) have high disease burden. It is important to restore quality of life (QoL) in treatment, so that patients become able to live a fulfilling life. Little is known about the longitudinal course of QoL in patients with OCD, its association with remission from OCD, and about factors that contribute to an unfavourable course of QoL in remitting patients. Methods Study on the 4-year course of QoL of patients with chronic (n = 144), intermittent (n = 22), and remitting OCD (n = 73) using longitudinal data of the Netherlands Obsessive Compulsive Disorder Association (NOCDA; complete data: n = 239; imputed data n = 382). The EuroQol five-dimensional questionnaire (EQ-5D) utility score was used to assess QoL. In patients with remitting OCD, we examined patient characteristics that contributed to an unfavourable course of QoL, including sociodemographics, OCD characteristics, psychiatric comorbidity, and personality traits. Results Course of QoL was associated with course of OCD. QoL improved in those who remitted from OCD; however, even in these patients, QoL remained significantly below the population norms. The correlation between QoL and severity of OCD was only moderate: r = − 0.40 indicating that other factors besides OCD severity contribute to QoL. In remitters, more severe anxiety and depression symptoms were related to a lower QoL. Results were similar in complete and imputed data sets. Conclusions Remission from OCD is associated with improvement of QoL, but comorbid anxiety and depression symptoms hamper the improvement of QoL. QoL could be improved by reducing OCD symptoms in patients with OCD and by treating comorbid anxiety and depression symptoms in remitting patients.

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Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study

et al. 2020

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Background Obsessive–compulsive disorder (OCD) is a complex disorder with 40%–60% of patients' refractory to treatment. Transcranial direct current stimulation (tDCS) has been shown to induce potent and long‐lasting effects on cortical excitability. The aim of the present clinical trial was to evaluate the therapeutic efficacy and tolerability of cathodal tDCS over the supplementary motor area (SMA) in treatment‐resistant OCD patients. Methods Twenty‐one treatment‐resistant OCD outpatients received 10 sessions of tDCS. Each treatment session consisted of 2 mA stimuli for 30 min. The cathode was positioned over the bilateral SMA and the anode over the right supraorbital area. Patients were evaluated at baseline, end of treatment, one‐month follow‐up, and three‐month follow‐up. Response to treatment was defined as at least a decrease of 35% on the Yale–Brown Obsessive–Compulsive Scale (YBOCS) and a score of 2 or less on the Clinical Global Impressions‐Improvement (CGI‐I) between baseline and 1‐month follow‐up. Results There was a significant decrease of YBOCS scores between baseline and one‐month assessment. At one month, five patients (24%) were considered as responders and 3 (15%) at 3 months. We also observed concomitant changes in depressive symptoms, and insight. The treatment was well tolerated. Short‐lasting side effects were reported as localized tingling sensation and skin redness. Conclusion Our results suggest that the use of cathodal tDCS over the SMA and anodal tDCS over the right supraorbital area in OCD treatment‐refractory patients is safe and promising to improve obsessive and compulsive symptoms. Large randomized controlled trials are needed to confirm this positive result.

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Clinical predictors of quality of life in a large sample of adult obsessive-compulsive disorder outpatients

Cited by 15 publications

References 62 publications

Relation of quality of life with clinical and demographic features in patients with obsessive-compulsive disorder: the effect of insight and suicidality

Relation of quality of life with clinical and demographic features in patients with obsessive-compulsive disorder: the effect of insight and suicidality

Four-year course of quality of life and obsessive–compulsive disorder

Treating refractory obsessive–compulsive disorder with transcranial direct current stimulation: An open label study

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