Clinical Predictors of Quality of Life in Patients With Initial Differentiated Thyroid Cancers

Almeida, Juliana Pereira; Vartanian, José Guilherme; Kowalski, Luiz Paulo

doi:10.1001/archoto.2009.16

Cited by 91 publications

(91 citation statements)

References 32 publications

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“…We therefore assumed that higher scores in DTC subjects than in the control group were not linked to this treatment. However, in 154 DTC subjects evaluated by means of the Portuguese version of the University of Washington QoL questionnaire from four months to ten years after radioiodine ablation, Almeida et al (2009) reported a relationship between QoL and therapy when activities above 5.55 GBq were administered. On the other hand, in a previous study involving the same inventory test, Dagan et al (2004) found that age was more important than treatments in determining answers to the University of Washington QoL questionnaire.…”

Section: Discussionmentioning

confidence: 99%

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Giusti

Melle

Fenocchio

et al. 2011

J. Zhejiang Univ. Sci. B

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Differentiated thyroid carcinoma (DTC) generally has a favorable outcome. Thyroid disease, treatments, stress, and comorbidity can compromise health-related quality of life (QoL) and indirectly weigh upon the outcome. From 2004 to 2008, we evaluated QoL longitudinally in 128 DTC subjects. During scheduled examinations, subjects were asked to undergo a semi-structured psychiatric interview and five rated inventories. The same examination was conducted in 219 subjects after surgery for benign thyroid pathology. Low scores represent a better QoL. DTC and control subjects were similar in terms of age, male/female ratio, concomitant psychopharmacological treatments, and frequency of psychiatric diseases. In DTC subjects, Billewicz scale (BS) scores showed an increasing trend over time, especially among females. The ad hoc thyroid questionnaire (TQ) scores were similar in both groups and did not change over time, but at the end of the study ad hoc TQ and BS were significantly related. Ad hoc TQ scores were also related to age on entry to the study. In both male and female DTC subjects, Hamilton's tests for anxiety (HAM-A), but not for depression (HAM-D), showed an improving trend. At the end of the study, HAM-A and HAM-D scores were comparable to those of the control group. HAM-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and treatment. Only HAM-D correlated with age on entry to the study. Kellner symptom questionnaire (KSQ) item scores were higher in DTC subjects than in controls. The change over time in the items including anxiety, somatization, depression, and hostility was significant. Somatization and hostility were more significantly reduced in DTC females than in DTC males. Hostility scores were significantly lower in DTC subjects than in controls at the end of the study. Somatization and depression were significantly related to staging on diagnosis and age on entry to the study. Our study confirms a wide variation of illness perception in DTC subjects, which is generally unrelated to the favorable clinical follow-up of the disease. Psychological evaluation during long-term follow-up improved QoL scores, which reached the same levels noted in subjects with a history of thyroid surgery for benign thyroid pathology. Our data indicate that special attention should be paid to QoL in older DTC subjects and those with more severe staging on diagnosis.

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Section: Discussionmentioning

confidence: 99%

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Giusti

Melle

Fenocchio

et al. 2011

J. Zhejiang Univ. Sci. B

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“…Moreover, one must take into consideration that iodine therapy in the juvenile population does not completely destroy the ability of the salivary glands to produce saliva, as the stimulus-response is still possible [21] [22]. Following the same line of reasoning, the measurements obtained by quantitative analysis showed, for the parotid glands, a significant difference between groups in excretion fraction (EF%), with reduced salivary excretion.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of Quality of Life Related to I-131 Therapy in Patients with Well-Differentiated Thyroid Cancer and Emphasis in Salivary Morbidity: A Follow up Study after Treatment

Corrêa¹,

Moriguchi²,

Boldrini³

et al. 2014

ABB

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Goal: To evaluate the impact of iodine-131 therapy received during childhood and adolescence and correlate it with the quality of life in these patients. Methods: We studied 19 patients diagnosed with cancer in childhood or adolescence who underwent thyroidectomy and supplemental therapy with I-131. We also recruited a control group of healthy subjects with the same demographic parameters. All patients were subjected to a scintigraphy examination of the salivary glands, and were also asked to complete a questionnaire in order to assess their overall quality of life. In addition, a more specific questionnaire for patients with head and neck cancer was also given to all study participants. Results: The quantitative and qualitative analyses of the salivary glands showed functional deficits with greater involvement of the parotid gland for volume, concentration and excretion. The right submandibular gland showed significant changes for volume in the patient group. The questionnaires made it possible to observe significant differences between the patient and control groups for symptoms such as thick saliva, dry mouth and speech problems. Conclusion: In spite of being very effective and widely used, iodine radionuclide therapy * Corresponding author. L. G. Corrêa et al. 410is correlated with a lower quality of life in young people.

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“…Many studies have discussed the effects of radioactive iodine, stating that they are dose-dependent, and recent studies have shown that doses higher than 150mCi are associated with more adverse effects on the salivary glands 5 .…”

Section: Methodsmentioning

confidence: 99%

“…In thyroid surgery, its comorbidities is postsurgical therapy with ¹³¹I leading to prolonged survival, and patients may present vocal alterations, dysphagia, sialadenitis, taste changes and xerostomia 5 .…”

Section: Short Term Quality Of Life Related To Voice and Swallowing Imentioning

confidence: 99%

“…Of these, 61 patients were not treated with ¹³¹I (iodine); 73 were treated with doses ≤ 150mCi and 20 with doses > 150mCi (73 patients ≤ 45 years and 81 patients > 45 years). It was concluded that, although the quality of life for the majority of patients treated with ¹³¹I is good, those who were subjected to doses > 150mCi had higher risks, requiring monitoring and more incisive treatments 5 .…”

Section: Short Term Quality Of Life Related To Voice and Swallowing Imentioning

confidence: 99%

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Qualidade de vida relacionada à voz e à deglutição, a curto prazo, em pacientes submetidos à radioiodoterapia por carcinoma diferenciado de tireoide

Nascimento¹,

Angelis

Lima

2015

Rev. CEFAC

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Qualidade de vida relacionada à voz e à deglutição, a curto prazo, em pacientes submetidos à radioiodoterapia por carcinoma diferenciado de tireoide José Ribamar do Nascimento Junior (1) , Elisabete Carrara-de Angelis (2) , Eduardo Nóbrega Pereira Lima (3)Instituto de Gerenciamento em deglutição -IGD São Paulo, SP, Brasil.Departamento de Fonoaudiologia do Hospital AC Camargo São Paulo, SP, Brasil.Departamento de Medicina Nuclear do Hospital AC Camargo, São Paulo, SP, Brasil. Conflict of interest: non-existentThe main structures at risk during thyroid surgery are the recurrent laryngeal nerves and parathyroid glands. The removal of the parathyroid glands can lead to hypoparathyroidism and consequent hypocalcemia 1,3 . Lesion to the inferior recurrent laryngeal nerve can result in vocal fold paralysis, which may cause permanent hoarseness. If the lesion is bilateral, aphonia and dyspnea are results of changes in the vocal folds 4 .In thyroid surgery, its comorbidities is postsurgical therapy with ¹³¹I leading to prolonged survival, and patients may present vocal alterations, dysphagia, sialadenitis, taste changes and xerostomia 5 .Sialadenitis is a possible side effect seen in treatment with high doses of ¹³¹I and correlates with the amount administered and physiological uptake, usually bilateral, in the region of the parotid or submandibular glands, which occurs within 48 INTRODUTCIONDiseases of the thyroid gland are common, affecting approximately 11% of the general population, with a predominance of female involvement over male in a ratio of 4:1 1 . The initial treatment of well-differentiated thyroid carcinoma consists in most cases of total or near total thyroidectomy with subsequent remnant ablation with iodine radioisotope (¹³¹I) followed by L-thyroxine (L-T4) suppression 2 . ABSTRACTPurpose: to analyze the quality of life related to voice and swallowing before and after radioiodine therapy in the short term. Methods: thiroidectomized individuals indicated RAI underwent two questionnaires on quality of life related to voice and swallowing before and three months after radioiodine therapy. Results: 32 patients, 84 % female and 16% male, were studied with a mean age of 46 years. The histological type was the classic papillary carcinoma (56%). The results indicated a tendency for better quality of life with respect to voice three months after radioiodine therapy. The protocol for quality of life related to swallowing also indicated better quality of life in the second assessment. A larger with minimal limitation on the quality of life questionnaire in swallowing was observed. Conclusion: quality of life and voice and swallowing symptoms in the short term after radioiodine therapy is better compared to pretreatment. It is necessary to investigate other aspects such as metabolic, surgical and individual to define the real impact of radioiodine therapy on quality of life.

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Clinical Predictors of Quality of Life in Patients With Initial Differentiated Thyroid Cancers

Abstract: Although QOL after treatment of thyroid cancer can be considered good for most patients, those submitted to RIT at doses higher than 150 mCi are at risk for poor QOL and, therefore, may need more intensive follow-up and treatment.

Cited by 91 publications

References 32 publications

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

Evaluation of Quality of Life Related to I-131 Therapy in Patients with Well-Differentiated Thyroid Cancer and Emphasis in Salivary Morbidity: A Follow up Study after Treatment

Qualidade de vida relacionada à voz e à deglutição, a curto prazo, em pacientes submetidos à radioiodoterapia por carcinoma diferenciado de tireoide

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