Clinical predictors of in-hospital prognosis in unstable angina: ECLA 3

Relevance of multivessel disease in the development of in-hospital refractory angina and myocardial infarction in patients with unstable angina

“…In addition, it was also found that patients who presented an AMI were older and had a higher incidence of smoking history, previous infarction, preceding angina (>1 month) and ST segment changes in the admission ECG than those without AMI. These clinical findings, however, are consonant with preceding investigations that have pointed to the association of advanced age [1 -3], smoking [14], antecedent myocardial infarction [1,3,15] and ST segment changes in the admission ECG [2,3,6] with development of inhospital or 30 days AMI or death in patients with acute coronary syndromes.…”

“…3. Frequency of 0, 1 and multivessel coronary disease [2,3] in patients who presented AMI and in those who had no in-hospital events (Unc.) during two different periods.…”

“…In patients with unstable angina (UA), age [1][2][3], ST segment shifts in the admission ECG [4 -6] and minor enzyme elevation [2,7 -9] have all been found to be associated with an increased rate of in-hospital events, including recurrent angina and acute myocardial infarction (AMI). The reasons for these associations, however, remain largely unclear.…”

Clinical research and trials in developing countries

“…They include the ECLA unstable angina registry [11], ECLA studies of glucose insulin potassium in AMI [12] and two large case-control studies of risk factors for AMI (co-ordinated by Mario Ciruzzi in Argentina [13] and a second study co-ordinated by Leopoldo Piegas and Alvaro Avezum in Brasil) [14].…”

Resultados del primer registro chileno de angina inestable: características clínicas, perfil de riesgo y tratamiento

“…Así, 94% de nuestros pacientes se presentó con dolor anginoso característico, 72% presentaba alteraciones de tipo isquémico en el ECG de ingreso y 30% tuvo elevación de marcadores de daño miocárdico a las 6 h de ingreso. Las características demográficas, prevalencia de factores de riesgo y antecedentes cardiovasculares previos de nuestra población fueron similares a las de otros registros como ECLA 3, OASIS y GRACE 13,6,9 . Llama la atención en nuestra serie la alta prevalencia de dislipidemia (52%), similar a la reportada recientemente en el Euro Heart Survey 10 , lo que podría explicarse porque actualmente existe una mayor conciencia médica sobre la necesidad de efectuar determinaciones de lípidos en pacientes que ingresan con síndromes coronarios agudos.…”