Clinical predictors for mechanical ventilation and prognosis in patients with Guillian-Barre syndrome: a 10-year experience

Shangab, Maha Osman Mohamed; Kaylani, Muhammed Al

doi:10.1007/s10072-021-05251-w

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Regarding EDx results, we found no difference in GBS subtypes in the group with respiratory failure, which is consistent with some studies ( Green, Baker & Subramaniam, 2018 ; Parveen et al, 2020 ) but contradicts others where a higher proportion of demyelinating ( Durand et al, 2006 ; Yamagishi et al, 2017 ) or axonal GBS subtypes was found ( Shangab & Al Kaylani, 2021 ; Walgaard et al, 2010 ; Islam et al, 2019 ; Luo et al, 2020 ).…”

Section: Discussionsupporting

confidence: 90%

“…Additionally, we found a higher male-to-female ratio of 2.6:1 compared to 1.6:1 in overall GBS, suggesting that males might have a higher morbidity than females ( Kasemsap et al, 2021 ). This observation is different from a meta-analysis that revealed that men were no more likely to require MV ( Green, Baker & Subramaniam, 2018 ) but was consistent with previous studies in Bangladesh and the United Arab Emirates, which showed that 68–78% of ventilated patients were male ( Shangab & Kaylani, 2021 ; Islam et al, 2019 ). The seasonal prevalence of GBS was comparable to previous studies confirming that the rainy and winter seasons had significantly more patients ( Areeyapinan & Phanthumchinda, 2010 ; Kasemsap et al, 2021 ).…”

Section: Discussionsupporting

confidence: 69%

“…Compared to previous epidemiological studies in Thailand, our patients with respiratory failure were older (50.6 vs. 42.0–43.0 years), which correlates to previous findings in which the mortality rate in the older age group was higher than the younger age group (5.2% in patients age ≥ 65 years compared to 1.5% and 3.6% in patients age ≥ 18 and 19–64 years, respectively) ( Areeyapinan & Phanthumchinda, 2010 ; Kasemsap et al, 2021 ; Wen et al, 2021 ). Similarly, Shangab & Al Kaylani (2021) reported that older age at presentation is a major predictor for the need for mechanical ventilation (MV). Additionally, we found a higher male-to-female ratio of 2.6:1 compared to 1.6:1 in overall GBS, suggesting that males might have a higher morbidity than females ( Kasemsap et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Respiratory failure is a common complication of GBS, caused by respiratory muscle weakness and impaired secretion clearance ( Green, Baker & Subramaniam, 2018 ). The prevalence of respiratory failure in GBS ranges from 13.0–50.9% ( Malaga et al, 2021 ; Shangab & Al Kaylani, 2021 ; Sharshar et al, 2003 ; Sudulagunta et al, 2015 ; Toamad et al, 2015 ; Umer et al, 2019 ; Ning et al, 2020 ). According to a recent meta-analysis, the clinical risk factors for respiratory failure in patients with GBS are a short time from symptom onset to hospital admission, bulbar or neck weakness, and severe muscle weakness on admission ( Green, Baker & Subramaniam, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Charoentanyarak

Singjam

Saengsuwan

2022

PeerJ

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Background Respiratory failure is a common complication of Guillain-Barré syndrome (GBS). This study aimed to determine the clinical predictors and electrodiagnostic (EDx) characteristics in patients with Guillain-Barré syndrome (GBS) with respiratory failure. Methods The retrospective study included 29 confirmed GBS cases with respiratory failure and age- (±5 years) and sex-matched controls (1:1). The dependent t-test and McNemar–Bowker test were used to analyse the continuous and categorical data, respectively. In addition, a multiple logistic regression analysis was used to analyse the predictive factors for respiratory failure. Results Among both cases and controls, the majority were male (72.4%), and the average age was 50.9 years. The data showed that patients with respiratory failure had higher GBS disability scores, lower motor power (≤3) of the hip flexors and ankle dorsiflexors, and experienced facial and bulbar palsy. In the multivariate analysis, the significant predictive factors were bulbar palsy (AOR 10.4 [95% CI [2.6–41.4]) and motor power of hip flexors ≤ 3 (AOR 31.4 [95% CI [3.1–314.5]). Patients with respiratory failure had lower compound muscle action potential amplitude of the ulnar and tibial nerves. The median, ulnar, and tibial nerve conduction studies were more likely to reflect inexcitability. The GBS subtypes in GBS patients with and without respiratory failure were not significantly different. Conclusions Bulbar palsy and motor power of the hip flexors ≤ 3 were significant predictors for respiratory failure. The GBS subtypes in patients with and without respiratory failure were not significantly different.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Charoentanyarak

Singjam

Saengsuwan

2022

PeerJ

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“…They found 65% patients had a high-risk score, 24% intermediate and 4% low-risk scores [27]. Shangab and their Colleagues found that 20 cases (24.4%) required MV at onset and axonal type was presented in 11 (55%) patients requiring intubation [38].Dysautonomia occurred in 19 patients (30.6%) and was significantly correlated with poorer outcomes in HDS and ONLS (P = 0.001, P = 0.001, respectively).…”

Section: Discussionmentioning

confidence: 95%

The early clinical and laboratory predictors of GBS outcome: hospital-based study, Assiut University, Upper Egypt

Khedr

Mohamed

Shehab

2023

Egypt J Neurol Psychiatry Neurosurg

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Background This study was designed to identify factors that influence outcomes in a large group of well-defined Guillain–Barré syndrome (GBS) patients with a 3-month follow-up period. Sixty-two cases of GBS with a mean age of 37.15 ± 17.60 years (33 males and 29 females) were recruited in the first 2 weeks after onset. Clinical history, examination, and a variety of rating scales including Medial Research Council sum score (MRC), Erasmus Guillain-Barré respiratory insufficiency score (EGRIS), at admission and 10 days later were performed. Follow-up investigations at 3 months included the Hughes Disability Scale (HDS), and Overall Neuropathy Limitation Scale (ONLS). Results 64.5% of participants had cranial nerve deficits, 45% had neck muscle weakness, 30.6% had dysautonomia, and 8.1% were mechanically ventilated. C-reactive protein was elevated in 38.7%, and hyponatremia was recorded in 30.6% of patients. Older age, antecedent events particularly diarrhea, neck muscles weakness, low MRC sum score, impaired cough reflex, dysautonomia, and hyponatremia, were all significantly associated with poor outcomes at 3 months using HDS and ONLS. Regression analysis with dependent variables of HDS outcome showed that the presence of an antecedent event particularly diarrhea, neck muscle weakness, hyponatremia and the presence cytoalbuminous dissociation of CSF at onset, and low MRC sum score at 10th day after treatment, were predictors of poor outcome. Conclusion Clinical and laboratory predictors of poor outcome were older age, the presence of an antecedent event particularly diarrhea, low MRC sum score at the 10th day, elevated CRP, hyponatremia and the presence cytoalbuminous dissociation.

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Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

İyigündoğdu,

Derle,

Kaya

et al. 2024

Cukurova Medical Journal

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Purpose: We aimed to evaluate the clinical characteristics of Guillain Barré syndrome (GBS) patients retrospectively and identify the prognostic factors associated with worse outcome at discharge and at the end of the first month in patients with GBS. Materials and Methods: Patients who were followed up with the diagnosis of GBS were evaluated retrospectively. Demographic characteristics of the patients, cerebrospinal fluid examinations, treatment regimens, Medical Research Council (MRC) and Hughes Motor Scale (HMS) scores were recorded and HMS ≥3 was accepted as associated with poor prognosis in patients. SPSS version 25 program was used in the statistical analysis of the data. p

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Clinical predictors for mechanical ventilation and prognosis in patients with Guillian-Barre syndrome: a 10-year experience

Cited by 5 publications

References 16 publications

Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

Clinical predictors and electrodiagnostic characteristics in patients with Guillain-Barré syndrome with respiratory failure: a retrospective, matched case-control study

The early clinical and laboratory predictors of GBS outcome: hospital-based study, Assiut University, Upper Egypt

Clinical characteristics and factors associated with functional outcome in patients with Guillain Barré syndrome

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