Clinical predictors for contralateral neck lymph node metastasis from unilateral squamous cell carcinoma in the oral cavity

Kitamura, Hiroshi; Koike, Takeshi; Narikawa, Jun-nosuke; Sakai, Hironori; Nakatsuka, Atsushi; Uehara, Shinobu; Kobayashi, H; Kurashina, Kenji

doi:10.1016/j.oraloncology.2004.04.004

Cited by 68 publications

(96 citation statements)

References 15 publications

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“…15 Since significant correlations have been reported between the histological mode of invasion and patient prognosis, 15,16,[19][20][21] we hypothesized that pain in patients with oral cancer may be significantly correlated with patient poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objectives:We have previously reported that the histological mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. We sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC. Study Design:We evaluated the relationships between overall survival rates (OSRs) and clinicopathological variables, including gender, age, Tand N-stages, pathological findings and pain in 109 consecutive patients with untreated OSCC. Results:Of these 109 patients, 40 (37%) reported spontaneous pain.Univariate analysis showed that the OSR of patients with spontaneous pain was significantly lower than that of patients without pain (p=0.002).Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of OSR. Conclusion:This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.3

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Section: Discussionmentioning

confidence: 99%

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Sato

Yamazaki

Satoh

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…Some authors recognize that contralateral metastases of head and neck carcinomas can occur in different ways: firstly, by crossing afferent lymph vessels; and second by tumor spreading over the midline to reach efferent collateral lymphatic vessels while ipsilateral lymph nodes are extensively involved, where there is not a real midline barrier in certain anatomic areas [7]. The incidence of CLNM differs considerably among institutions from 0.9% to 36% [6,[8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Incidence Of Clnm In Osccmentioning

confidence: 99%

“…Therefore, tumors arising in the region between both canines have been excluded in several studies recently in order to determine the relationship between primary tumor features and the appearance of CLNM. Interestingly, OSCC extending the midline have been related to the most important predictors of contralateral or bilateral metastases on multivariate logistic regression analysis [6,8,11,13], due to the involvement of the contralateral lymphatic drainage. In 1951, Martin et al [10] reported that primary tumor invasion crossing the midline of oral cavity was associated with a higher incidence of contralateral metastases.…”

Section: Tumor Locationmentioning

confidence: 99%

A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

et al. 2011

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Oral squamous cell carcinoma (OSCC) has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy (aRT) and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.

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“…The status of the regional lymphatics is one of the most important prognostic indicators in patients with head and neck cancer 5,6,7,8 . Treatment of the neck in patients with clinical evidence of nodal metastasis has traditionally been surgical, that is systematic removal of all the lymphatic tissues called as radical neck dissection (RND) described by Crile and later popularized by Martin 9,10,11 .Dissemination of metastatic cancer to regional lymph nodes from primary sites in the upper aerodigestive tract occurs in a predictable and sequential fashion.…”

Section: Discussionmentioning

confidence: 99%

“…The management of cancer with bilateral lymph node metastasis to the neck remains controversial 17 . Prediction of contralateral metastases may be useful in planning more aggressive therapies in patients with head and neck SCC with poor prognosis 5,6 . Morbidity with two stage bilateral procedure is worthy of consideration as apprehension exists regarding safety of simultaneous bilateral neck dissection.…”

Section: Discussionmentioning

confidence: 99%