Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study

Abstract

PurposeThis study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase CINV prophylaxis in the Korean population subset of the Pan Australasian Chemotherapy Induced Emesis burden of illness (PrACTICE) study.Materials and MethodsThis subgroup analysis evaluated 158 Korean patients receiving HEC or MEC and compared the data (wherever possible) with that of 648 patients from the Asia-Pacific (AP) region. Study endpoints included evaluation of primary CINV prophylaxis and adherence to acute-phase CINV prophylaxis in cycle 1 (American Society of Clinical Oncology [ASCO] Quality Oncology Practice Initiative [QOPI]).ResultsIn South Korea and the AP, a 5-hydroxytryptamine-3 receptor antagonist (5HT3-RA) prophylaxis for the acute phase was administered to 79/80 patients (98.8%) for HEC and 70/71 patients (98.6%) for MEC regimens (QOPI-1). Triple regimen (corticosteroid–5HT3-RA–neurokinin 1-RA) was initiated in 46/80 patients (57.5%) for prophylaxis of acute CINV in cycle 1 of HEC (QOPI-3). Double regimen (corticosteroid–5HT3-RA, with or within NK1-RA) was initiated in 61/71 patients (83.1%) for control of acute CINV in cycle 1 of MEC a(QOPI-2).ConclusionActive management of CINV is necessary in cycle 1 of HEC in South Korea, despite higher rates than the AP region. Adherence to the international guidelines for CINV prophylaxis requires attention in the acute phase in cycle 1 of the HEC regimen.

Chemotherapy-Associated nausea and vomiting: A cross-sectional survey of occurrence and management patterns at jos university teaching hospital, Nigeria

“…Despite the frequent prescribing of ondansetron and corticosteroids, a large proportion of patients did not receive these agents for acute- or delayed-phase prophylaxis, leading to low antiemetic guideline adherence and hence suboptimal CANV management. Observational studies carried out in India and South Korea have also reported higher prescribing rates for 5-HT3RAs and corticosteroids,[ 14 15 ] than those observed in the current study. Inadequate clinician knowledge on antiemetic prescribing is thought to have contributed to this difference.…”

Construção e avaliação de bundle frente ao extravasamento de antineoplásicos: estudo metodológico

“…Várias diretrizes recomendam regimes antieméticos profiláticos para náuseas e vômitos. (23) As sugestões dos juízes para as condutas gerais, específicas e no uso de antídotos e compressas foram quanto dividir o item relatar e registrar qualquer incidência envolvendo o extravasamento de AA e; a ação registrar, por meio de fotografia, a imagem da área afetada, sendo que para tanto deverá haver consentimento por escrito do paciente.…”

Expert Consensus on Effective Management of Chemotherapy-Induced Nausea and Vomiting: An Indian Perspective

“…Healthcare accessibility, coupled with issues such as variable management practices and lack of sensitization for guidelines, has made the development of region-specific CINV-management guidelines the need of the hour (19). Findings from previously conducted multination Pan Australasian ChemoTherapy InduCed Emesis burden of illness (PrACTICE) study reported vast variation in the complete response (CR) rate (∼50-87%) among patients from different participating countries (20).…”

“…On the other hand, Australia reported higher proportions of patients with no emesis compared to other Asian countries. Additionally, Asian countries, including India, reported high use and prescribing behavior of CINV rescue medication (20). Considering the response variations of various antiemetic agents, region-specific management guidelines are the need of the hour.…”