Clinical Practice of Interstitial Thermoradiotherapy

Seegenschmiedt, M. Heinrich; Klautke, Günther; Seidel, Ralph; Stauffer, Paul R.

doi:10.1007/978-3-642-60938-1_15

Cited by 12 publications

(8 citation statements)

References 173 publications

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“…Preferential heating of diOE erent tumour regions is achieved by the lower convection of heat from relatively poor vasculated areas of tumours compared to their surrounding tissues. The use of isolated limb perfusion and other perfusion techniques has recently been reviewed by Urano et al (1999), and an excellent review on local interstitial hyperthermia has been published by Seegenschmiedt et al (1995).…”

Section: Clinical Application Of Hyperthermiamentioning

confidence: 99%

Hyperthermia in oncology

Falk¹,

Issels²

2001

Int. J. Hyperthermia

540

291

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The purpose of this article is to provide an overview on the current clinical application of hyperthermia combined with conventional treatment modalities (e.g. ionizing radiation, chemotherapy) in the treatment of malignant disease. The clinical application of hyperthermia with increase of tissue temperatures (range 40-44 degrees C) has been integrated in multimodal anti-cancer strategies. This review describes selected phase I or II (n = 17) and phase III trials (n = 16) investigating the effect of hyperthermia combined with radiotherapy (n = 10 trials), chemotherapy (n = 15 trials), or both (n = 8 trials) in a total of more than 2200 patients. The trials were performed in a variety of solid tumours (e.g. melanoma, head and neck cancer, breast cancer, cancer of the gastrointestinal or urogenital tract, glioblastoma, sarcoma) in paediatric or adult patients. Profound research has produced a scientific basis for the simultaneous application of hyperthermia in combination with ionizing radiation and/or systemic chemotherapy. Hyperthermia is becoming more accepted clinically, due to the substantial technical improvements made in achieving selected increase of temperatures in superficial and deep-seated tumours. At present, the combination of hyperthermia and chemotherapy or radiochemotherapy is further tested within clinical protocols (phase II/III) in order to improve local tumour control and relapse-free survival in patients with high-risk or advanced tumours of different entities.

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Section: Clinical Application Of Hyperthermiamentioning

confidence: 99%

Hyperthermia in oncology

Falk¹,

Issels²

2001

Int. J. Hyperthermia

540

291

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“…The combination of brachytherapy with hyperthermia has recently been extensively reviewed by Seegenschmiedt et al (76). By means of different heating techniques such as radiofrequency capacitive heating, microwaves, ferromagnetic seed or hot water sources, CR was obtained in 55 -65% and PR in another 25 -30% of patients.…”

Section: Interstitial Thermoradiotherapymentioning

confidence: 99%

Status of Clinical Hyperthermia

Dahl

Dalene²,

Bc³

et al. 1999

Acta Oncologica

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“…As demonstrated by the articles in this volume, the results of recent re-engineering of previous interstitial heating systems are substantially increased power delivery and treatment volume per implanted source. Notwithstanding the evolution in source geometry and associated power delivery systems, the underlying physics lessons of earlier research involving RF, MW, US, laser and thermal conduction 'hot source' technologies remain equally valid today and should be considered useful background to assist continued development 32,34,35,[37][38][39] .…”

mentioning

confidence: 99%

“…With the notable exception of highly focused external beam ultrasound, much of the equipment for high temperature thermal ablation has either evolved from earlier development efforts or stems from independent efforts that parallel or duplicate principles characterized in the interstitial moderate temperature hyperthermia field. Results of decades of equipment development for interstitial hyperthermia applications have been summarized previously [31][32][33][34][35] . One important and fortuitous difference for interstitial heating equipment applied to thermal ablation treatments is that, rather than aiming for a narrow therapeutic window of only 41-45 C, the high temperature thermal ablation systems can aim to treat tissue over a much larger temperature range from 50-100 C or more.…”

mentioning

confidence: 99%

Introduction: Thermal ablation therapy

Stauffer

Goldberg

2004

International Journal of Hyperthermia

105

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The diseases which medicines cannot cure, excision cures: those which excision cannot cure, are cured by the cautery; but those which the cautery cannot cure, may be deemed incurable (Hippocrates Aphorisms, 400 BCE).Ever since initial discoveries of fire and ice, medical applications of thermal energy have continued to increase in both number and sophistication. Initially, treatments were limited to very cold (ice) or very hot (cautery) temperatures that could not be controlled but were maintained for a sufficient time to obtain visually obvious effects on surface tissues. Over time, therapeutic applications of hot and cold temperature have increased in clinical complexity in direct correspondence with improvements in the devices and techniques used to deliver and monitor the effects of thermal energy. Efforts to generate specific interactions with tissue in a safe and reproducible manner have been restricted by the availability of controllable energy sources (cryotherapy, radiofrequency (RF), microwave (MW), laser, etc.), accurate monitoring systems (MR, CT, thermal mapping, etc.), and problems/complications unique to treating each specific organ (liver, prostate, brain, heart, skin, etc.). At present, due to the wide range of possible therapeutic effects, 'thermal medicine' is often practiced independently with large variation in methodology based on geography as well as sub-discipline within the medical community.To meet the specialized demands of various clinical applications, site-specific applicators and condition-specific treatment protocols have been developed, refined and further customized to meet evolving requirements. While optimization of thermal therapy techniques for specific medical conditions has produced many therapeutic tools, the development continues to evolve in numerous directions at once. While parallel development can speed the time to useful solutions, without due caution and co-ordination it can suffer from repeated mistakes and brilliant but non-innovative re-development efforts. This special issue on thermal ablation is an attempt to publish in one place representative ongoing efforts from a cross-section of sub-disciplines, thereby enhancing visibility of conclusions made under similar research conditions. By encouraging cross-fertilization of results, one might anticipate further acceleration of development timeframes.In order to simplify reading articles written for the various sub-disciplines, a uniform language is encouraged. While standardized terminology for tumour ablation has already been proposed 1 , due to the range of disciplines covered in International Journal of Hyperthermia Int J Hyperthermia Downloaded from informahealthcare.com by Nyu Medical Center on 08/01/15 For personal use only.this special issue it seems appropriate to reiterate the essence of that standard and supplement its content with additional clarification of general thermal therapy concepts as apply to hot, warm and cold temperatures alike. It is anticipated that efforts to consolidate a 'lingua communa...

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Clinical Practice of Interstitial Thermoradiotherapy

Cited by 12 publications

References 173 publications

Hyperthermia in oncology

Hyperthermia in oncology

Status of Clinical Hyperthermia

Introduction: Thermal ablation therapy

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