Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding before menopause

Marret, H.; Fauconnier, Arnaud; Chabbert-Buffet, Nathalie; Cravello, L.; Golfier, François; Gondry, J.; Agostini, Aubert; Bazot, M; Brailly-Tabard, Sylvie; Brun, J L; Raucourt, Emmanuelle de; Gervaise, A.; Gompel, Anne; Graesslin, Olivier; Huchon, Cyrille; Lucot, J P; Plu‐Bureau, Geneviève; Roman, Horace; Fernandez, H.

doi:10.1016/j.ejogrb.2010.07.016

Cited by 150 publications

(107 citation statements)

References 44 publications

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“…Treatment protocols generally suggest treating CH with progestins, and atypical hyperplasia (AH) with hysterectomy. In contrast, the necessity for a hysterectomy and progestins to treat patients with CH and AH continues to be controversial (Epplein et al, 2008;Marret et al, 2010). However, the efficacy of hormonal therapy for patients with endometrial hyperplasia remains unclear, and most relevant studies are based on large case series.…”

Section: Efficacy Of Progestins For Control In Cases Of Hyperplasiamentioning

confidence: 99%

“…The prevalence of abnormal uterine bleeding (AUB) is 11-13% in the general population, and increases with age, reaching 24% in females aged 36-40 years (Marret et al, 2010). AUB may be acute or chronic and is defined as bleeding from the uterine corpus that is abnormal in regularity, volume, frequency, or duration and occurs in the absence of pregnancy (Munro et al, 2011;ACOG, Practice Bulletin, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Endometrial Curettage in Abnormal Uterine Bleeding and Efficacy of Progestins for Control in Cases of Hyperplasia

Mesci-Haftaci

Ankaralı²,

Yavuzcan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Abnormal uterine bleeding (AUB) is the most important symptom of endometrial hyperplasia and endometrial curettage (EC) is the gold standard diagnostic procedure. We present the results of patients who underwent EC for AUB and the efficacy of progestin administration in those with endometrial hyperplasia. Materials and Methods: A total of 415 female patients who presented to Duzce Public Hospital in 2011-2012 for AUB and who underwent EC were included. We determined the reasons for AUB, and females with hyperplasia were treated with 10 mg/day medroxyprogesterone acetate for 14 days/month or 160 mg/day megestrol acetate continuously for 3 months. We evaluated the efficacy of progestins for periods of three and/or six cycles by repeating EC. A statistical analysis of specific endometrial causes according to age of presentation was conducted using the chi-square test. Results: Among the 415 females (average age, 53.5 years) followed for 6 months, 186 had physiological changes (44.8%), 89 had simple hyperplasia (21.44%), 1 had atypical hyperplasia (0.2%), 6 had (1.44%) complex hyperplasia, 3 had (0.72%) atypical complex hyperplasia, and 5 had adenocarcinoma (1.2%). Regression rates were 72.7-100%, and the optimum results were observed after 6 months of hormonal therapy. Conclusions: The main cause of AUB was physiological change. Progestin therapy resulted in significant regression even in females with atypical hyperplasia.

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Section: Efficacy Of Progestins For Control In Cases Of Hyperplasiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endometrial Curettage in Abnormal Uterine Bleeding and Efficacy of Progestins for Control in Cases of Hyperplasia

Mesci-Haftaci

Ankaralı²,

Yavuzcan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The guidelines also recommend the placement of a levonorgestrel IUD for women with idiopathic abnormal uterine bleeding. 1 Similarly, authors of a recent systemic review on nonsurgical management of heavy menstrual bleeding recommend the use of the levonorgestrel intrauterine system over oral contraceptive pills (OCPs), luteal-phase progestins, and NSAIDs for the reduction of blood loss in women with heavy menstrual bleeding. 27 Based on the compelling evidence of overall efficacy and safety from numerous clinical trials, use of LNG-IUS can be considered as the first line therapy for Indian patients with heavy menstrual bleeding ( Figure 5).…”

Section: Place For the Use Of Lng-ius In Idiopathic Abnormal Uterine mentioning

confidence: 99%

Levonorgestrel intrauterine system: A first line medical therapy for idiopathic heavy menstrual bleeding

Mahapatra¹,

Kapur²,

Baxi³

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…Все пришли к единому мнению, что получение развернутого анализа крови рекомендует-ся в случае обильного или длительного маточного кровотечения [8]. Дополнительные анализы крови показаны в следующих ситуациях [1,8,16]:…”

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“…Следует уделить особое внимание при появле-нии признаков, которые дают основание заподо-зрить малигнизацию [1,8,16,20,21]:…”

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Heavy menstrual bleeding: modern approach to problem solution

Андреева¹

2015

Probl. reprod.

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Проблема обильных менструальных кровотече-ний (ОМК) остается одной из нерешенных в гине-кологической практике, распространенность ОМК до конца не известна. Сбору информации мешает разница в культурных, социальных и возрастных восприятиях «нормальной» менструации [1,2]. При этом во многих странах есть табу на эту тему [3]. Культура замалчивания темы менструации препят-ствует обращению за советом и помощью [5]. Кроме того, менструальная кровь в некоторых странах мо-жет восприниматься как «медицинское очищение» или знак принадлежности к женскому полу [4,5]. В сознании людей наличие менструации чаще всего означает фертильность и отсутствие беременности [5].При проведении эпидемиологических исследо-ваний (n=475) выяснилось, что, с одной стороны, 41% женщин с кровопотерей более 80 мл считают свои менструации необильными или даже скудны-ми. С другой стороны, 14% женщин, теряющих ме-нее 20 мл менструальной крови, считали свои мен-струации обильными [6], что свидетельствует о низ-ком уровне осведомленности населения и понима- This review contains information about the status of the problem of heavy menstrual bleeding in the world, methods of diagnostics, pharmacotherapy and surgical treatment of heavy menstrual bleeding including algorithms and recommendations of international group of experts HELP (HMB: Evidence-based Learning for Best Practice).

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Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding before menopause

Cited by 150 publications

References 44 publications

Endometrial Curettage in Abnormal Uterine Bleeding and Efficacy of Progestins for Control in Cases of Hyperplasia

Endometrial Curettage in Abnormal Uterine Bleeding and Efficacy of Progestins for Control in Cases of Hyperplasia

Levonorgestrel intrauterine system: A first line medical therapy for idiopathic heavy menstrual bleeding

Heavy menstrual bleeding: modern approach to problem solution

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