Clinical practice guidelines for the diagnosis and management of atopic dermatitis

Kulthanan, Kanokvalai; Tuchinda, Papapit; Nitiyarom, Rattanavalai; Chunharas, Amornsri; Chantaphakul, Hiroshi; Aunhachoke, Kobkul; Chularojanamontri, Leena; Rajatanavin, Natta; Jirapongsananuruk, Orathai; Vichyanond, Pakit; Chatchatee, Pantipa; Sangsupawanich, Pasuree; Wananukul, Siriwan; Singalavanija, Srisupalak; Trakanwittayarak, Suphattra; Rerkpattanapipat, Ticha; Thongngarm, Torpong; Wisuthsarewong, Wanee; Limpongsanurak, Wanida; Kamchaisatian, Wasu; Noppakun, Nopadon

doi:10.12932/ap-010221-1050

Cited by 18 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approximately 230 million people globally are affected by atopic dermatitis (International League of Dermatological Societies, 2022) and 20% of children have been diagnosed with atopic dermatitis (Gilaberte et al, 2020). The primary characteristic of atopic dermatitis is extreme itching and scratching (Kulthanan et al, 2021). Children with atopic dermatitis suffer from physical pain, sleep disturbances, and interpersonal difficulties due to severe pruritus (Ali et al, 2020;Kulthanan et al, 2021).…”

Section: Date Of Publicationmentioning

confidence: 99%

Nursing Interventions for Children with Atopic Dermatitis and Their Families

Kim,

Choi

2023

McN: The American Journal of Maternal/Child Nursing

View full text Add to dashboard Cite

Purpose: The purpose of this scoping review was to summarize and synthesis studies about nursing interventions for children and adolescents with atopic dermatitis and their families. Methods: A scoping review was conducted and described as per PRISMA-ScR via four electronic databases, PubMed, Web of science, Scopus, and EBSCOhost, evaluating research on nursing interventions for children diagnosed with atopic dermatitis and their families. Results: Eleven articles were included in the review. Nursing interventions were conducted for children, parents, or both and primarily focused on education, consultation, and management of complications. Outcomes of the interventions showed improvements in atopic dermatitis severity for children and enhanced quality of life for children and their families. Clinical Implications: Nursing interventions targeting children and parents have been found to be effective in alleviating the severity of atopic dermatitis in children and improving their quality of life. Despite the increasing prevalence of atopic dermatitis in children, studies on nursing interventions are insufficient and outdated. Future research should focus on providing comprehensive and age-appropriate interventions for children with atopic dermatitis and their families to improve their well-being and overall quality of life.

show abstract

Section: Date Of Publicationmentioning

confidence: 99%

Nursing Interventions for Children with Atopic Dermatitis and Their Families

Kim,

Choi

2023

McN: The American Journal of Maternal/Child Nursing

View full text Add to dashboard Cite

show abstract

“…Monotherapy or combination therapy with topical or systemic agents represent the two possible uses. [ 6 , 45 ]. However, numerous factors can limit phototherapy’s usefulness and effectiveness, especially because it requires cycles of bi-weekly sessions, so it can be difficult for patients who live far from centers equipped with this technology [ 46 ].…”

Section: Atopic Dermatitis Treatmentmentioning

confidence: 99%

“…Furthermore, phototherapy causes downregulation of cytokines, such as IL-5, IL-13, and IL-31, supporting the hypothesis that these molecules play a crucial role in the pathogenesis of AD and, therefore, may represent possible targets for phototherapy [ 43 ]. Moreover, phototherapy induces T-cell apoptosis and dendritic cell reduction [ 6 ]. In fact, the T-cell response in the skin of AD patients is predominantly Th2/Th22 even if patients with chronic disease develop a sizable pool of pathogenic Th1.…”

Section: Atopic Dermatitis Treatmentmentioning

confidence: 99%

“…AD is characterized by immune activation, marked epidermal hyperplasia, and defective barrier function, reflecting underlying alterations in keratinocyte differentiation [ 5 ]. AD may be associated with high serum levels of total and specific immunoglobulin E (IgE) against a given allergen (extrinsic form) or with normal–low serum levels of IgE (intrinsic form) [ 6 ]. Genetic, immunological, and environmental factors contribute to its pathogenesis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

et al. 2022

View full text Add to dashboard Cite

Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy.

show abstract

“…In this approach, a high-potency TCS of the same rank as the initial treatment is used intermittently as maintenance treatment after remission is achieved. PA therapy was reported to reduce the risk of both AD relapse and adverse effects of TCS treatment [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. PA therapy also provided significantly better rash control and quality of life compared with reactive therapy (on-demand TCS use upon relapse) in pediatric patients with AD aged 3 months to 7 years [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Proactive versus Rank-Down Topical Corticosteroid Therapy for Maintenance of Remission in Pediatric Atopic Dermatitis: A Randomized, Open-Label, Active-Controlled, Parallel-Group Study (Anticipate Study)

Saeki

Tokura²,

Yoshihara

et al. 2022

JCM

View full text Add to dashboard Cite

Topical corticosteroids are used as first-line treatment for atopic dermatitis (AD). Regarding the maintenance of remission achieved by topical corticosteroids, no previous studies have compared proactive therapy with rank-down therapy. We compared their efficacy and safety in Japanese children with moderate to severe AD. Patients who had achieved remission with a very strong topical corticosteroid were randomized to 4-week maintenance treatment with either intermittent use of the same drug (proactive therapy) or daily use of a strong topical corticosteroid for 1 week followed by daily use of a medium-potency topical corticosteroid for 3 weeks (rank-down therapy); 49 patients were randomized (proactive therapy, n = 24; rank-down therapy, n = 25). During maintenance treatment, the relapse rate was 8.33% in the proactive therapy group and 20.0% in the rank-down therapy group (p = 0.0859). The mean (±standard deviation) itching score on a numerical rating scale in the rank-down therapy group increased significantly from 2.5 ± 1.9 to 3.6 ± 2.6 (p = 0.0438). Adverse events occurred in 2 patients receiving proactive therapy and 3 patients receiving rank-down therapy. Proactive therapy appears to be as safe as rank-down therapy and may be more effective for itch in pediatric AD in remission.

show abstract

Clinical practice guidelines for the diagnosis and management of atopic dermatitis

Cited by 18 publications

References 0 publications

Nursing Interventions for Children with Atopic Dermatitis and Their Families

Nursing Interventions for Children with Atopic Dermatitis and Their Families

Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

Proactive versus Rank-Down Topical Corticosteroid Therapy for Maintenance of Remission in Pediatric Atopic Dermatitis: A Randomized, Open-Label, Active-Controlled, Parallel-Group Study (Anticipate Study)

Contact Info

Product

Resources

About