Clinical Practice Guidelines for Prenatal Aneuploidy Screening and Diagnostic Testing from Korean Society of Maternal-Fetal Medicine: Cell-Free DNA Screening

Choe, Seung‐Ah; Kim, Kunwoo; Seol, Hyun Joo; Lee, Ji Yeon; Kim, Min-A; Kim, Min-Hyoung; Kwon, Ji Young; Hwang, Han Sung; Park, Chan-Wook; Na, Sunghun; Shim, Jae-Yoon; Ryu, Hyun Mee

doi:10.3346/jkms.2020.35.e326

Cited by 1 publication

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“…Noninvasive prenatal testing (NIPT) is a method to screen for chromosomal abnormalities in the fetus, such as Down syndrome, Patau syndrome, and Edward syndrome, using cell-free DNA fragments from the fetus that are circulating in a pregnant woman's blood [1]. In particular, NIPT has been reported to have high sensitivity and specificity in assessing the risk of Down In 2019, the Korean Society of Maternal Fetal Medicine prepared medical guidelines for NIPT, with recommendations to inform and offer NIPT choice to all pregnant women, preferentially for women with high-risk pregnancies, to screen for trisomy 21, 18, and 13 and sex chromosome aneuploidy [6]. In Korea, highrisk pregnancies, including those in women with advanced maternal age (35 years or older), are steadily increasing [7], and it is expected that the use of NIPT will expand among these women.…”

Section: Introductionmentioning

confidence: 99%

Informed choice of pregnant women regarding noninvasive prenatal testing in Korea: a cross-sectional study

Choi

2022

Korean J Women Health Nurs

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Purpose: This study explored the degree to which pregnant women in Korea made informed choices regarding noninvasive prenatal testing (NIPT) and investigated factors influencing whether they made informed choices.Methods: In total, 129 pregnant women in Korea participated in a web-based survey. Multidimensional measures of informed choice regarding NIPT and decisional conflict were used to measure participants’ levels of knowledge, attitudes, deliberation, uptake, and decisional conflict related to NIPT. Additional questions were asked about participants’ NIPT experiences and opinions.Results: All 129 pregnant women were recruited from an online community. Excluding those who expressed neutral attitudes toward NIPT, according to the definition of informed choice used in this study, only 91 made an informed choice (n=63, 69.2%) or an uninformed choice (n=28, 30.8%). Of the latter, 75.0% had insufficient knowledge, 39.3% made a value-inconsistent decision, and 14.3% did not deliberate sufficiently. No difference in decisional conflict was found between the two groups. A significant difference was found between the two groups in the reasons why NIPT was introduced or recommended (p=.021). Multiple logistic regression analysis showed that pregnant women who were knowledgeable (odds ratio [OR], 4.77; 95% confidence interval [CI], 2.17–10.47) and deliberated (OR, 0.74; 95% CI, 0.57–0.98) were significantly more likely to make an informed choice.Conclusion: The results of this study help healthcare providers, including nurses in maternity units, understand pregnant women’s experiences of NIPT. Counseling strategies are needed to improve pregnant women’s knowledge of NIPT and create an environment that promotes deliberation regarding this decision.

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Section: Introductionmentioning

confidence: 99%

Informed choice of pregnant women regarding noninvasive prenatal testing in Korea: a cross-sectional study

Choi

2022

Korean J Women Health Nurs

View full text Add to dashboard Cite

show abstract

Clinical Practice Guidelines for Prenatal Aneuploidy Screening and Diagnostic Testing from Korean Society of Maternal-Fetal Medicine: Cell-Free DNA Screening

Cited by 1 publication

References 40 publications

Informed choice of pregnant women regarding noninvasive prenatal testing in Korea: a cross-sectional study

Informed choice of pregnant women regarding noninvasive prenatal testing in Korea: a cross-sectional study

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