Clinical practice guidelines for pediatric constipation

Greenwald, Beverly

doi:10.1111/j.1745-7599.2010.00517.x

Cited by 12 publications

(13 citation statements)

References 5 publications

(6 reference statements)

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“…Oral laxative medications to treat constipation include high-dose mineral oil, polyethylene glycol electrolyte solutions, or a combination of both. Other options include high-dose magnesium citrate, magnesium hydroxide, sorbitol, lactulose, senna, or bisacodyl (Greenwald, 2010). …”

Section: Basic Clinical Evaluation and Managementmentioning

confidence: 99%

Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America

Giugliani

Villarreal²,

Valdez

et al. 2014

Genet. Mol. Biol.

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This review aims to provide clinicians in Latin America with the most current information on the clinical aspects, diagnosis, and management of Hunter syndrome, a serious and progressive disease for which specific treatment is available. Hunter syndrome is a genetic disorder where iduronate-2-sulfatase (I2S), an enzyme that degrades glycosaminoglycans, is absent or deficient. Clinical manifestations vary widely in severity and involve multiple organs and tissues. An attenuated and a severe phenotype are recognized depending on the degree of cognitive impairment. Early diagnosis is vital for disease management. Clinical signs common to children with Hunter syndrome include inguinal hernia, frequent ear and respiratory infections, facial dysmorphisms, macrocephaly, bone dysplasia, short stature, sleep apnea, and behavior problems. Diagnosis is based on screening urinary glycosaminoglycans and confirmation by measuring I2S activity and analyzing I2S gene mutations. Idursulfase (recombinant I2S) (Elaprase®, Shire) enzyme replacement therapy (ERT), designed to address the underlying enzyme deficiency, is approved treatment and improves walking capacity and respiratory function, and reduces spleen and liver size and urinary glycosaminoglycan levels. Additional measures, responding to the multi-organ manifestations, such as abdominal/inguinal hernia repair, carpal tunnel surgery, and cardiac valve replacement, should also be considered. Investigational treatment options such as intrathecal ERT are active areas of research, and bone marrow transplantation is in clinical practice. Communication among care providers, social workers, patients and families is essential to inform and guide their decisions, establish realistic expectations, and assess patients’ responses.

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Section: Basic Clinical Evaluation and Managementmentioning

confidence: 99%

Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America

Giugliani

Villarreal²,

Valdez

et al. 2014

Genet. Mol. Biol.

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“…Constipation, a common cause of abdominal discomfort and painful defecation, is defined as the less-frequent passage of stool or the passage of hard stool 1 . Since most of the patients with constipation have symptoms for many years, it is considered a chronic disorder 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, the American Society of Colon and Rectal Surgeons regards fiber, fluid supplementation and osmotic laxatives as initial management, and stimulant laxatives as second-line treatment. Surgical management is considered for refractory colonic slow-transit constipation 1, 5, 9, 10 . While there are many therapeutic options available, the combination of high prevalence, side effects of treatment, high recurrence rate and low patient satisfaction level has prompted searches for new, original approaches.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles

Qian

Cai

et al. 2017

Sci Rep

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Constipation, mainly manifesting as abdominal discomfort and painful defecation, is considered as a chronic disorder. Due to a lack of effective therapy, it imposes a significant economic burden and greatly impacts patients’ quality of life which prompt searches for new, original approaches. Based on the research of vibrating capsule (VC) carried out by Ron et al., we investigated the safety and efficacy of an innovative, multi-mode VC in terms of its effect on defecation in animal studies. The parameters associated with different operation modes of VCs can be detected and adjusted by smartphone controlled external configuration device (ECD). The results of blood tests, physiological parameters, CT scan and pathological examination showed no significant abnormality, which undoubtedly confirmed the safety of VCs. For efficacy studies, defecation frequency of beagles increased after administration of these capsules without influence on stool characters. Meanwhile, the mean time of capsule evacuation tended to be reduced while showing no significant difference between different modes. In summary, this study elucidates the safety and effectiveness of VC in prompting the passage of gastrointestinal walls thus greatly increasing the defecation frequency. This study innovatively displays the promising application of VC in the treatment of constipation.

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“…1 Education. 5 Food choices include barley cereal, pureed higher fi ber fruits such as apricots, sweet potatoes, pears, prunes, peaches, plums, beans, peas, broccoli, or spinach. Toddlers may require several months of laxative-produced soft stools to recover from withholding practices.…”

Section: Diagnosis and Management Of Functional Constipationmentioning

confidence: 99%

Diagnosis and management of functional constipation

Petersen

2014

The Nurse Practitioner

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Clinical practice guidelines for pediatric constipation

Abstract: Purpose: To discuss the diagnosis and management of pediatric constipation by nurse practitioners in primary care.

Cited by 12 publications

References 5 publications

Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America

Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America

Safety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles

Diagnosis and management of functional constipation

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