Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease

Lantos, Paul M.; Rumbaugh, Jeffrey A.; Bockenstedt, Linda K.; Falck‐Ytter, Yngve; Agüero-Rosenfeld, Maria E.; Auwaerter, Paul G.; Baldwin, Kelly; Bannuru, Raveendhara R.; Belani, Kiran; Bowie, William; Branda, John A.; Clifford, David B.; DiMario, Francis J.; Halperin, John J.; Krause, Peter J.; Lavergne, Valéry; Liang, Matthew H.; Meissner, H. Cody; Nigrovic, Lise E.; Nocton, James J.; Osani, Mikala C.; Pruitt, Amy A.; Rips, Jane; Rosenfeld, Lynda E.; Savoy, Margot; Sood, Sunil K.; Steere, Allen C.; Strle, Franc; Sundel, Robert P.; Tsao, Jean I.; Vaysbrot, Elizaveta E.; Wormser, Gary P.; Zemel, Lawrence

doi:10.1002/art.41562

Cited by 41 publications

(84 citation statements)

References 6 publications

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“…Lastly, these findings that human‐tick encounters can serve as a proxy for TBD in LD prevention studies should not be extrapolated to influence clinical recommendations for individual human‐tick encounters. Rather, infection risk should be assessed on an individual basis per clinical guidelines (Lantos et al., 2020).…”

Section: Discussionmentioning

confidence: 99%

Human‐tick encounters as a measure of tickborne disease risk in lyme disease endemic areas

Hook

Nawrocki

Meek

et al. 2021

Zoonoses and Public Health

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Entomological measures have long served as proxies for human risk of Lyme disease (LD) and other tickborne diseases (TBDs) in endemic areas of the United States, despite conflicting results regarding the correlation between these measures and human disease outcomes. Using data from a previous TBD intervention study in Connecticut, Maryland and New York, we evaluated whether human‐tick encounters can serve as an accurate proxy for risk of TBDs in areas where LD and other Ixodes scapularis‐transmitted infections are common. Among 2,590 households consisting of 4,210 individuals, experiencing a tick encounter was associated with an increased risk of both self‐reported (RR = 3.17, 95% CI: 2.05, 4.91) and verified TBD (RR = 2.60, 95% CI: 1.39, 4.84) at the household level. Household characteristics associated with experiencing any tick encounter were residence in Connecticut (aOR = 1.86, 95% CI: 1.38, 2.51) or New York (aOR = 1.66, 95% CI: 1.25, 2.22), head of household having a graduate level education (aOR = 1.46, 95% CI: 1.04, 2.08), owning a pet (aOR = 1.80, 95% CI: 1.46, 2.23) and a property size of 2 acres or larger (aOR = 2.30, 95% CI: 1.42, 3.70). Results for individual characteristics were similar to those for households. Future prevention studies in LD endemic areas should consider using human‐tick encounters as a robust proxy for TBD risk.

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Section: Discussionmentioning

confidence: 99%

Human‐tick encounters as a measure of tickborne disease risk in lyme disease endemic areas

Hook

Nawrocki

Meek

et al. 2021

Zoonoses and Public Health

View full text Add to dashboard Cite

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“…While unusual, the onset of cranial nerve involvement after the initiation of antibiotics can occur. Treatment with oral antibiotics is possible once meningitis has been excluded [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Lyme Disease in the Era of COVID-19: A Delayed Diagnosis and Risk for Complications

Novak

Scheeler

Aucott

2021

Case Reports in Infectious Diseases

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We describe a patient with fever and myalgia who did not have COVID-19 but instead had Lyme disease. We propose that the co-occurrence of COVID-19 and Lyme disease during the spring of 2020 resulted in a delayed diagnosis of Lyme disease due to COVID-19 pandemic-related changes in healthcare workflow and diagnostic reasoning. This delayed diagnosis of Lyme disease in the patient we describe resulted in disseminated infection and sixth nerve palsy. We present the use of telemedicine to aid in the diagnosis of Lyme disease and to provide prompt access to diagnosis and care during the ongoing COVID-19 pandemic and in the future.

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“…is choice was based on the recommendation that "A growing body of evidence suggests that oral doxycycline is effective for the treatment of Lyme meningitis and may be used as an alternative to hospitalization and parenteral ceftriaxone therapy in children who are well enough to be treated as outpatients." [12,13] Her symptoms resolved with antibiotic therapy. After the completion of therapy, a repeat fundoscopic exam demonstrated improvement in optic disc edema (Figure 2).…”

Section: Case Reports In Infectious Diseasesmentioning

confidence: 98%

Papilledema as the Sole Manifestation of Neuroborreliosis

May

Upadhyayula

2021

Case Reports in Infectious Diseases

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Lyme disease is reportable, and approximately 30,000 cases/year are notified to the local and state health departments. However, other estimates based on insurance records suggest there are close to 476,000 cases/year that are diagnosed and treated. In addition to a large burden of illness, areas where Lyme disease is common are expanding. Therefore, clinicians should be aware of uncommon presentations of this condition. We describe the case of a 5-year-old girl who presented with papilledema as an isolated manifestation of Lyme disease. Of note, her ocular symptoms were intermittent and worse when tired. In endemic areas, Lyme disease must be considered in the differential diagnosis for patients presenting with isolated ophthalmic findings even outside the usual Lyme season.

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Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease

Cited by 41 publications

References 6 publications

Human‐tick encounters as a measure of tickborne disease risk in lyme disease endemic areas

Human‐tick encounters as a measure of tickborne disease risk in lyme disease endemic areas

Lyme Disease in the Era of COVID-19: A Delayed Diagnosis and Risk for Complications

Papilledema as the Sole Manifestation of Neuroborreliosis

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