Clinical practice

Ariceta, Gema

doi:10.1007/s00431-010-1334-0

Cited by 28 publications

(32 citation statements)

References 36 publications

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“…The SAP group most commonly exhibited Lee grade III IgAN, and pathological classifications were generally more severe than in the MGH group. Microalbuminuria was a sensitive indicator of early renal injury [22]. Our study shows that the detection of microalbuminuria level in IH patients, especially in adult patients, has some clinical significance in determining pathological type.…”

Section: Discussionmentioning

confidence: 88%

Clinicopathologic analysis of isolated hematuria in child/adolescent and adult patients

Chen¹,

Zhu²,

Song³

et al. 2015

pjp

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contributed equally to this work and should be considered co-first authors.To our knowledge, no in-depth clinicopathologic study of isolated hematuria (IH) is currently available. To address this gap, we analyzed the clinicopathologic features of IH as it manifests in child/adolescent and adult patients. The clinical data and pathological types of 543 IH patients who underwent renal pathological examinations from January 2005 to June 2010 were retrospectively analyzed. Clinical manifestations differed among the age groups: children/adolescents exhibited the highest percentage of mesangial proliferative glomerulonephritis (41.78%), whereas adults showed the highest percentage of immunoglobulin A nephropathy (IgAN) (52.39%). In addition, the percentage of IH patients who were classified according to clinical pathology differed from that of patients who were classified according to renal pathological type. Patients with IgAN who were found to have minimal proteinuria had more severe IH. For IH patients, especially those with a small amount of proteinuria, renal biopsy should be performed as early as possible in order to develop a long-term treatment plan and prognosis evaluation.

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Section: Discussionmentioning

confidence: 88%

Clinicopathologic analysis of isolated hematuria in child/adolescent and adult patients

Chen¹,

Zhu²,

Song³

et al. 2015

pjp

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“…12 The laboratory exams we performed and the clinical history of our patient allow us to exclude some possible causes of transient proteinuria such as vigorous exercise, fever, dehydration, or urinary tract infection. A renal biopsy, generally indicated in steroid-unresponsive NS, 13 was not performed so the histological pattern associated with proteinuria cannot be established.…”

Section: Discussionmentioning

confidence: 99%

Massive Proteinuria: A Possible Side Effect of Pyrantel Pamoate?

et al. 2011

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Drug-induced renal injury represents a frequent clinical entity. The most common drugs associated with acute tubular necrosis are aminoglycosides, amphotericin B, radiocontrast agents, and cyclosporine, but no data exist about the potential renal toxicity due to anthelmintics administration. Anthelmintics are commonly considered quite safe agents, and side effects such as gastrointestinal, neurologic, hematologic, or hepatic injury have been only rarely described. We report a 4-year-old boy with persistent massive proteinuria without any other symptoms/signs suggesting nephrotic syndrome (NS). The only relevant anamnestic data was the administration of pyrantel pamoate due to oxyuriasis 7 days before the proteinuria development. The patient was affected by NS diagnosed 6 months before and treated with a 12-week course of corticosteroids. During follow-up, carried out at 3 and 6 months after discharge, he did not show further episodes of proteinuria, and no clinical symptoms/signs suggesting a relapse of NS were ever detected. Considering that the proteinuria observed in our patient spontaneously disappeared after 10 days without any treatment, apart from the interruption of the anthelmintic therapy, we would like to alert pediatricians about the possible occurrence of anthelmintics-related renal complications especially among predisposed patients and to perform a watchful waiting not considering the presence of even massive proteinuria as a certain sign of NS relapse.

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“…Blood pressure and renal function are normal in children with abnormal urinalysis, who recover completely within 1-3 weeks without any therapy. Acute febrile non-renal illnesses in which kidney function is preserved may be accompanied by increased urinary protein excretion [2]. Hence, we assume that in acute hemorrhagic edema of young children, a transiently increased urinary protein excretion does not necessarily reflect a renal disease state [2].…”

Section: Clinical Presentationmentioning

confidence: 99%

Acute hemorrhagic edema of young children: a concise narrative review

et al. 2011

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Acute hemorrhagic edema of young children is an uncommon but likely underestimated cutaneous leukocytoclastic vasculitis. The condition typically affects infants 6-24 months of age with a history of recent respiratory illness with or without course of antibiotics. The diagnosis is made in children, mostly nontoxic in appearance, presenting with nonpruritic, large, round, red to purpuric plaques predominantly over the cheeks, ears, and extremities, with relative sparing of the trunk, often with a target-like appearance, and edema of the distal extremities, ears, and face that is mostly non-pitting, indurative, and tender. In boys, the lesions sometimes involve the scrotum and, more rarely, the penis. Fever, typically of low grade, is often present. Involvement of body systems other than skin is uncommon, and spontaneous recovery usually occurs within 6-21 days without sequelae. In this condition, laboratory tests are non-contributory: total blood cell count is often normal, although leukocytosis and thrombocytosis are sometimes found, clotting studies are normal, erythrocyte sedimentation rate and C-reactive protein test are normal or slightly elevated, complement level is normal, autoantibodies are absent, and urinalysis is usually normal. Experienced physicians rapidly consider the possible diagnosis of acute hemorrhagic edema when presented with a nontoxic young child having large targetoid purpuric lesions and indurative swelling, which is non-pitting in character, and make the diagnosis either on the basis of clinical findings alone or supported by a skin biopsy study.

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Clinical practice

Cited by 28 publications

References 36 publications

Clinicopathologic analysis of isolated hematuria in child/adolescent and adult patients

Clinicopathologic analysis of isolated hematuria in child/adolescent and adult patients

Massive Proteinuria: A Possible Side Effect of Pyrantel Pamoate?

Acute hemorrhagic edema of young children: a concise narrative review

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