Clinical Phenotyping of Women With Interstitial Cystitis/Painful Bladder Syndrome: A Key to Classification and Potentially Improved Management

Nickel, J. Curtis; Shoskes, Daniel A.; Irvine-Bird, Karen

doi:10.1016/j.juro.2009.02.122

Cited by 166 publications

(116 citation statements)

References 16 publications

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“…Sufferers of IC/PBlS frequently report depressive symptoms [2] and diminished health-related quality of life (HRQL) [3]. Biopsychosocial factors are suggested to be relevant to poor IC/PBlS outcomes [4,5], but a wider consideration of social factors and patient outcomes is warranted, given the few biomedical treatments available for IC/PBlS and their limited effectiveness [6].…”

Section: Introductionmentioning

confidence: 99%

Spousal support decreases the negative impact of pain on mental quality of life in women with interstitial cystitis/painful bladder syndrome

Ginting

Tripp²,

Nickel

et al. 2010

BJU International

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Study Type – Symptom prevalence (case series)Level of Evidence 4What’s known on the subject? and What does the study add?Research has demonstrated that significant others influence the course of pain experienced by individuals with chronic pain. Generally, spousal responses to pain behaviour are associated with higher levels of pain, disability, and depression.The present research discusses novel findings regarding how spousal responses to patient pain behaviour influences the impact of pain on mental quality of life in women with IC/PBS. These findings go beyond correlations, and begin to untangle the circumstances under which pain influences mental quality of life. Women with IC/PBS would benefit from spouse‐led distraction as a way to help them cope with their pain.OBJECTIVE• To examine whether spousal responses to patient pain would alter the association between pain and patient health‐related quality of life (HRQL), depression and disability.METHODS• Ninety‐six women with IC/PBlS (mean age = 50.6 (13.8); mean time since diagnosis = 6.2 years) completed questionnaires on demographics, depressive symptoms (Center for Epidemiological Studies‐Depression Scale), disability (Pain Disability Index), HRQL (Medical Outcomes Study Short Form 12) and a measure of perceived spousal responses to their pain (Multidimensional Pain Inventory).• A repeated measures multivariate analysis of variance examined association changes between pain and adjustment variables at high, moderate and low levels of negative, solicitous and distracting spousal responses.RESULTS• The association between pain and all outcome variables did not vary as a function of levels of solicitous and negative spousal responses.• However, the association between pain and mental HRQL was stronger at lower levels (β=−1.25) of distracting responses than it was at moderate (β=−0.66) and higher (β=−0.06) levels.CONCLUSION• Distracting spousal responses act to ‘buffer’ the deleterious effects of pain on mental HRQL for women suffering from IC/PBlS. Spousal support training may be a useful HRQL intervention.

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Section: Introductionmentioning

confidence: 99%

Spousal support decreases the negative impact of pain on mental quality of life in women with interstitial cystitis/painful bladder syndrome

Ginting

Tripp²,

Nickel

et al. 2010

BJU International

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“…The modification asked the subject to recall if the symptoms were present in childhood, specifically between the ages of 8 and 10. Data regarding the patients' demographics, symptom duration, Interstitial Cystitis Symptoms Index (ICSI), Interstitial Cystitis Problem Index (ICPI) scores, 26 Pelvic Pain and Urgency/ Frequency (PUF), UPOINT scoring, 27 and the presence or absence of IBS (diagnosed and/or Rome III criteria) were collected through initial evaluations at the IC/ BPS outpatient clinic and has been previously reported. 9 …”

Section: Methodsmentioning

confidence: 99%

Childhood bladder and bowel dysfunction predicts irritable bowel syndrome phenotype in adult interstitial cystitis/bladder pain syndrome patients

d’Oiron

Kogan

Tolls

et al. 2017

CUAJ

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Introduction: Many clinicians have suggested that a history of bladder and bowel dysfunction (BBD) in childhood predisposes to the development of interstitial cystitis/bladder pain syndrome (IC/BPS) or irritable bowel syndrome (IBS) in adulthood. We hypothesized that BBD symptoms in childhood would predict the IBS-associated phenotype in adult IC/BPS patients. Methods: Consecutive female patients (n=190) with a diagnosis of IC/BPS were administered a modified form of a clinical BBD questionnaire (BBDQ) to capture childhood BBD-like symptoms, as well as Interstitial Cystitis Symptoms Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Pelvic Pain and Urgency/ Frequency (PUF) questionnaires and UPOINT categorization. Patients were stratified to IBS-positive or IBS-negative according to clinical assessment of IBS-like symptoms. Results: The 127 patients (67%) identified with IBS-like symptoms recalled significantly higher BBDQ scores than the 63 patients (33%) who were IBS-negative (2.8 vs. 2.3; p=0.05). The IBS-positive patients also reported a higher number of UPOINT domains than their non-IBS counterparts (3.8 vs. 2.9; p=0.0001), while their PUF total scores were significantly higher (13.6 vs. 12.3; p=0.04). IBSpositive patients more often recalled that in childhood they did not have a daily bowel movement (BM) (p=0.04) and had "to push for a BM" (p=0.009). In childhood, they "urinated only once or twice per day" (p=0.03) and recalled "painful urination" more than those without IBS (p=0.03). There were no significant differences between the groups in answers to the other five questions of the BBDQ. Conclusions: Our symptom recollection survey was able to predict the IBS phenotype of IC/BPS based on a childhood BBDQ. Further prospective studies are needed to further evaluate these novel findings.

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“…In a disease of unknown etiology, subtyping and phenotyping, such as that proposed by the European Society for the Study of Interstitial Cystitis 8 and Nickel et al, 9 are crucial in defining which groups of patients will respond better to a certain treatment.…”

Section: Editorial Comment Editorial Comment From Professor Dinis To mentioning

confidence: 99%

Editorial Comment from Dr Yoshimura to Potential therapeutic effect of intravesical botulinum toxin type A on bladder pain syndrome/interstitial cystitis

Yoshimura

2014

Int J of Urology

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This Review Article by Jhang well summarizes the recent advancement for the use of intravesical botulinum toxin injection for the treatment of bladder pain syndrome/interstitial cystitis, as well as the potential mechanisms underlying the therapeutic efficacy of the botulinum toxin treatment, such as peripheral desensitization, reduction of apoptotic changes in urothelial cells and suppression of bladder inflammation. Although some studies showed therapeutic efficacy of botulinum toxin for bladder pain, frequency, bladder capacity and symptom score in bladder pain syndrome/interstitial cystitis patients, larger-sized, randomized trials with a placebo control are definitely required to confirm the efficacy. Also, the methods of botulinum toxin treatment including dosage, injection site/number and treatment interval vary among studies, and need to be standardized.

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Clinical Phenotyping of Women With Interstitial Cystitis/Painful Bladder Syndrome: A Key to Classification and Potentially Improved Management

Cited by 166 publications

References 16 publications

Spousal support decreases the negative impact of pain on mental quality of life in women with interstitial cystitis/painful bladder syndrome

Spousal support decreases the negative impact of pain on mental quality of life in women with interstitial cystitis/painful bladder syndrome

Childhood bladder and bowel dysfunction predicts irritable bowel syndrome phenotype in adult interstitial cystitis/bladder pain syndrome patients

Editorial Comment from Dr Yoshimura to Potential therapeutic effect of intravesical botulinum toxin type A on bladder pain syndrome/interstitial cystitis

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