Clinical phenotype of recurrent aphthous stomatitis and interleukin‐1β genotype in a Polish cohort of patients

Abstract

The presence of IL-1 β *2 allele within the c.+3954 and c.-511 SNPs was found to be neither a significant risk factor for a higher incidence of any type of RAS, nor did it influence the disease severity and mode of recurrences.

Could recurrent aphthous stomatitis be linked to cancer development?

“…Using this infor--mation alone, it may be postulat--ed that RAS is being inherited in an autosomal dominant fashion. This would be in direct contradic--tion to the initial proposal of auto--somal recessive inheritance in 1965 [4]. However, this family is relatively small, making the sam--ple size too small to reliably de--termine mode of inheritance from the pedigree alone.…”

“…It is thought that disruption in both the humoral and cellular immune systems con--tribute to the occurrence of RAS [4,5]. Specifically, im--paired activation of proin--flammatory components such as tumor necrosis factors and interleukin--1 (IL--1) have been implicat--ed [4,5]. The IL--1 family are primary activators of the expression of endothe--lial cell adhesion mole--cules which facilitates the migration of leukocytes into tissues [4].…”

“…Specifically, im--paired activation of proin--flammatory components such as tumor necrosis factors and interleukin--1 (IL--1) have been implicat--ed [4,5]. The IL--1 family are primary activators of the expression of endothe--lial cell adhesion mole--cules which facilitates the migration of leukocytes into tissues [4]. A member of the IL--1 family, IL--1β, is primarily released by monocytes and macro--phages, as well as some nonimmune cells, such as fibroblasts and endothelial cells at sites of injury to stimulate in--creased migration of leukocytes [6].…”

“…RAS is also known to accumulate in families, giving fur--ther strength to the theory of a genetic cause [5]. Early studies proposed an autosomal recessive or multigene mode of inheritance with environmental influences [4]. This paper aims to explore the possible connection between RAS and cancer development by examining a family with a history http://dentistry3000.pitt.edu of RAS as well as cancer.…”

“…This condition is charac--terized by painful erosions or ul--cers surrounded by an erythema--tous halo on the non--keratinized oral mucosa [2,4]. The lesions may affect the day to day activities of the patients, especially eating, drinking and speaking [3].…”