Clinical phenotype and outcome of hepatitis E virus associated neuralgic amyotrophy; an international retrospective comparative cohort study

Jones, K.J.E.; Eijk, J.J.J. van; Ripellino, Paolo; Madden, R.G.; Herrod, Jenny; Lissmann, Rebecca; Webb, Glynn W.; Abdelrahim, Mohamed; Ashraf, Hamad H.; AlMasri, Omar; McLean, Brendan; Gobbi, Claudio; Moradpour, Darius; Küntzer, Thierry; Fraga, Montserrat; Sahli, Roland; Perón, José Miguel Rodríguez; Blasco-Perrin, Hélène; Izopet, Jacques; Colson, Philippe; Attarian, S.; Gerolami, René; Hartl, Johannes; Pischke, Sven; Giordani, Mauro; Fritz, Miriam; Panning, Marcus; Bendall, Richard; Lin, Na; Alfen, Nens van; Engelen, B.G.M. van; Jacobs, Bart C.; Dalton, Harry R.

doi:10.1016/s0168-8278(17)30380-x

Cited by 2 publications

(1 citation statement)

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“…Among the neuro-muscular manifestations, the commonly reported were neuralgic amyotrophy (n = 102/179; 56.98%) [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] and Guillain-Barré syndrome (n = 36/179; 20.11%) [10,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. The other rarer neurological manifestations that were reported include mononeuritis multiplex [10], encephalitis [11,13,39,41], cerebral ischemia [11,39], myasthenia gravis [42], polyneuromyopathy [24,43], meningo-radiculitis [10,44], epilepsy [11], encephalopathy [45], facial nerve palsy…”

Section: Neurological and Musculoskeletal Manifestationsmentioning

confidence: 99%

A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection

et al. 2020

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Hepatitis E virus (HEV) is a non-enveloped, positive-sense, single-stranded RNA icosahedral virus belongs to the genus Orthohepevirus within the Hepeviridae family. HEV infection can be asymptomatic, or it can cause icteric or fulminant hepatitis. Off late, there have been a number of publications reporting the extra-hepatic manifestations of HEV infection, and this systematic review is aimed at summarizing the available evidence in this regard. Two independent investigators searched PubMed, PubMed Central and Embase databases using the search string “(((hepatitis E) AND (Extrahepatic OR Extra-Hepatic))) OR ((Hepatitis E) AND (Neurology OR Cardiology OR Respiratory OR Lung OR Gastrointestinal OR musculoskeletal OR immunology OR pulmonary)) Filters: Abstract availability, English language, and Human studies”. The extra-hepatic manifestations reported in each of the selected articles were classified and reported as neurological, cardiovascular, and hematological and miscellaneous manifestations. The total number of various manifestations reported in our study were n = 324. These include neurological manifestations (n = 178/324 (54.94%)), cardiovascular and hematological manifestations (n = 113/324 (34.88%)), gastro-intestinal/pancreaticobiliary manifestations (n = 24/324 (7.41%)) and other rarer manifestations involving systems such as renal (n = 4/324; 1.24%), endocrine (n = 1/324; 0.31%), dermatology (n = 1/324; 0.31%), respiratory (n = 1/324; 0.31%), muscular (n = 1/324; 0.31%) and immune system (n = 1/324; 0.31%). Thus, HEV can have extra-hepatic manifestations affecting any system of the human body. Further research is needed to elucidate the underlying pathophysiological manifestations of these extra-hepatic manifestations and to prove causal association with HEV.

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Section: Neurological and Musculoskeletal Manifestationsmentioning

confidence: 99%

A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection

et al. 2020

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Extrahepatic Replication Sites of Hepatitis E Virus (HEV)

Yadav

Kenney

2023

Zoonotic Diseases

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Hepatitis E virus (HEV) is an emerging viral disease known to cause acute viral hepatitis globally. Various genotypes of HEV have been identified that produce genotype specific lesions depending on the HEV targeted population. Pregnant or immunosuppressed individuals develop significantly more severe hepatitis E in comparison to the general population. In the last 40 years, we discovered that the tropism of HEV is not restricted to the liver, and virus replication was demonstrated in multiple organs. Out of the 10 body systems described in humans, HEV produces lesions causing a broad range of extrahepatic clinical manifestations in each of them. Affected body systems include nervous and musculoskeletal, cardiovascular, digestive, endocrine, integumentary, renal, respiratory, immune, and reproductive systems producing systemic lesions. All extrahepatic signs are caused by either direct HEV replication in these tissues, or indirectly by various immune mediated mechanisms. Extrahepatic replication features of HEV allowed it to cross the placental barrier, blood–brain barrier (BBB), and blood–testis barrier (BTB) that do not typically grant entry to viruses in general. Thus, in this review, we summarized the extrahepatic replication sites of HEV, listed the body systems where HEV invaded, and described multiple animal models including immunocompetent and immunosuppressed that were used to study the extrahepatic replication sites of HEV.

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Clinical phenotype and outcome of hepatitis E virus associated neuralgic amyotrophy; an international retrospective comparative cohort study

Cited by 2 publications

References 0 publications

A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection

A Systematic Review of the Extra-Hepatic Manifestations of Hepatitis E Virus Infection

Extrahepatic Replication Sites of Hepatitis E Virus (HEV)

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