Clinical Phenomenology of Fibromyalgia Syndrome in Male Patients: Same But Different

Drusko, Armin; Renz, Malika; Schmidt, Hannah; Schlömp, Lea; Papaiannou, Vassilios; Schmidt, Norbert; Tost, Heike; Treede, Rolf‐Detlef; Eich, Wolfgang; Tesarz, Jonas

doi:10.1016/j.jpain.2023.06.020

Cited by 1 publication

(1 citation statement)

References 46 publications

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“…Fibromyalgia (FM) is common pain disorder, affecting 2.7% in the general population, with a greater occurrence (4:1) in females than males [87]. FM patients suffer from chronic musculoskeletal pain, mechanical hypersensitivity, high sensitivity to cold, fatigue, and cognitive difficulties.…”

Section: Fibromyalgiamentioning

confidence: 99%

Satellite Glial Cells in Human Disease

Hanani

2024

Cells

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Satellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suffering from common painful diseases, such as rheumatoid arthritis and fibromyalgia, may contribute to the pain phenotype. It was found that immunoglobulins G (IgG) from fibromyalgia patients can induce pain-like behavior in mice. Moreover, these IgGs bind preferentially to SGCs and activate them, which can sensitize the sensory neurons, causing nociception. In other human diseases, the evidence is not as direct as in fibromyalgia, but it has been found that an antibody from a patient with rheumatoid arthritis binds to mouse SGCs, which leads to the release of pronociceptive factors from them. Herpes zoster is another painful disease, and it appears that the zoster virus resides in SGCs, which acquire an abnormal morphology and may participate in the infection and pain generation. More work needs to be undertaken on SGCs in humans, and this review points to several promising avenues for better understanding disease mechanisms and developing effective pain therapies.

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Section: Fibromyalgiamentioning

confidence: 99%

Satellite Glial Cells in Human Disease

Hanani

2024

Cells

View full text Add to dashboard Cite

show abstract

Clinical Phenomenology of Fibromyalgia Syndrome in Male Patients: Same But Different

Cited by 1 publication

References 46 publications

Satellite Glial Cells in Human Disease

Satellite Glial Cells in Human Disease

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