“…4,[6][7][8][9] Dysmenorrhoea may be secondary to conditions such as pelvic inflammatory disease, intra-uterine contraceptive devices, endometriosis, uterine fibroids, and adenomyosis. [10][11][12] The diagnosis of premenstrual symptoms and dysmenorrhoea is based on history alone although a physical examination should be carried out to exclude other causes of the symptoms. 1,13 Although the cause of these symptoms is not clear, it is believed that most of them are due to changes in the levels of some hormones and their metabolites such as prolactin, oestrogen, progesterone, endorphins, and prostaglandins, and their interactions with neurotransmitters and neurohormonal systems such as serotonin, GABA, cholecystokinin and the renin-angiotensin-aldosterone system.…”