Clinical performance of a dedicated self-apposing stent for the treatment of left main stem disease. Results of the left Main AngioplasTy wIth a Self-apposing StEnt - the MATISSE study

Cortese, Bernardo; Montefusco, Antonio; D’Ascenzo, Fabrizio; Manna, Alessio La; Andò, Giuseppe; Bisceglia, Teodoro; Secco, Gioel Gabrio; Meyer‐Geßner, Markus; Wańha, Wojciech; Sganzerla, Paolo; Napodano, Massimo; Palma, Gaetano Di; Latini, Roberto; Tamburino, Corrado; Orrego, Pedro Silva; Baumbach, Andreas

doi:10.1016/j.carrev.2018.03.005

Cited by 5 publications

(3 citation statements)

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“…Xposition S as shown by the low rate of POT or FKB reported in this study and also in previous studies evaluating a self-apposing stent in ULMCA. 3,5 Although this deviates from the EBC consensus statement which recommends these procedural steps, 8…”

Section: Stent Optimization Techniques Are Deemed Less Essential Withmentioning

confidence: 87%

“…Xposition S also allows treatment of large vessels, such as can be encountered in most LMCA lesions. The device was studied in a broad set of lesions, including LM lesions, [2][3][4][5] showing promising results. The Xposition S for TReatment of UNprotected left main Coronary artery disease (TRUNC; ClinicalTrials.gov Identifier: NCT02800837) is the first large prospective study to evaluate the acute and long-term results that can be achieved with this technology in patients with ULMCA lesions.…”

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confidence: 99%

“…The results of this study confirm the findings of previous smaller scale studies investigating the Xposition S stent in ULMCA disease. In the MATISSE retrospective study,3 151 patients were treated with Xposition S for ULMCA lesions, reporting on a MACE rate of 9.3% at 9 months follow-up, with 1.3% cardiac death, 2.6% target-vessel related MI, and 5.3% TLR. In the LM-STENTYS retrospective Polish registry,5 175 LM patients were treated with Xposition S and subsequently divided into stable angina and acute coronary syndrome (ACS) groups.…”

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confidence: 99%

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Prospective evaluation of drug eluting self‐apposing stent for the treatment of unprotected left main coronary artery disease: 1‐year results of the TRUNC study

Briguori

Tamburino

Jessurun

et al. 2019

Cathet Cardio Intervent

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Objectives: To assess long-term safety and efficacy of the Xposition S self-apposing stent in the treatment of unprotected left main coronary artery (ULMCA) disease. Background: Percutaneous intervention with stents has emerged as a valid alternative to surgical revascularization to treat ULMCA disease. Conventional balloon-expandable stents face technical challenges, particularly in large left main diameter requiring extensive optimization and side branch access in distal bifurcation. Xposition S allows for optimal apposition, bridging diameter differences, and allows expansion to vessel diameters up to 6.0 mm. Methods: Between June 2016 and July 2017, 205 patients were enrolled in this international, prospective, multicenter registry. Patients with SYNTAX score ≥ 33 or recent STEMI were excluded. IVUS during procedure was performed in a prespecified subgroup of 50 patients. The primary clinical endpoint was 12 months Target lesion failure (TLF) and the primary efficacy endpoint was angiographic success. Results: Distal left main bifurcation was involved in 92.7%, treated with provisional approach in most cases (79.4%). TLF rate at 12 months was 8.3%, which was defined as a composite of cardiac death (2.0%), target-vessel MI (2.9%), and TLR (5.4%). Most revascularizations occurred at SB ostium. IVUS analysis demonstrated optimal stent apposition with only one reported malapposition and promising poststenting minimal stent area measures. Conclusions: The TRUNC study confirms that Xposition S self-apposing stent is a valid and feasible option for the treatment of ULMCA disease. Such results were reached without the systematic need of stent optimisation techniques, focusing mainly on lesion treatment. 1 | INTRODUCTION Although coronary artery bypass grafting (CABG) is the historical gold standard, recent randomized studies suggest that percutaneous coronary intervention (PCI) is now a valid alternative for selected patients with unprotected left main coronary artery (ULMCA) disease. 1 In this complex population, the use of conventional balloon-expandable stents may present technical limitations, due to a fixed stent size, which

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Section: Stent Optimization Techniques Are Deemed Less Essential Withmentioning

confidence: 87%

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confidence: 99%

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confidence: 99%

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