Background and objectives. Zinc deficiency increases risk of infections, allergies and autoimmunity. We wished to determine risk factors in severe atopic dermatitis (AD) and identify of hypozincemia rate. Materials and methods. Retrospective study done on AD children (≤ 14 years) with serum zinc test. Data included demographic and laboratory tests (serum zinc level, IgE, food-specific IgE), and skin tests. Results. 168 AD children, aged 38.9 months with concomitant allergies in 47 (28%), family history of allergies in 131 (80%), and parental consanguinity in 134 (79.9%). AD was mild in 12 (7.2%, SCORAD 15.8) children, moderate in 41 (24.5%, SCORAD 30.4), and severe in 115 (68.3%, SCORAD 69.4). Hypozincemia was observed in 42 (25%, zinc 8.6 ± 1.1 µmoI/L) children and associated only with severe AD (p = 0.0418) and elevated IgE (p = 0.001). Conclusions. Hypozincemia is rather prevalent in AD, and severe AD and high IgE increase its risk. An adjunct oral zinc may help reducing severe poorly responsive AD. is associated with uncommon but significant complications such as infections (4), poor weight gain, marked malnutrition, or trace elements deficiency (5). Published literature on zinc deficiency and its association with AD is increasing. The significance of hypozincemia in AD seems to be poorly understood. There are no studies on how common zinc deficiency is in moderate-to-severe AD among children and on the risk factors. The aims of this study were to determine how common zinc deficiency is among children with AD, and to determine any risk factors for zinc deficiency in these children. Materials and methods In this retrospective study, we reviewed records of all children, 14 years or less, seen at our Pediatric Allergy-Immunology Clinics at Hamad General Hospital with severe AD and serum zinc level tested. Serum zinc level was considered low in AD chil