Clinical patterns and epidemiological characteristics of melasma in a tertiary care hospital of Nepal

Introduction: Melasma is the most common cause of facial melanosis and one of the most common diseases presenting to the Dermatology department. It can lead to psychological and emotional distress for the patients and can hamper their quality of life. So, this study was done to assess the quality of life among patients with melasma so that the need for couseling of these patients could be assessed along with medical treatment. Materials and Methods: This was a hospital based cross sectional study with 205 clinically diagnosed cases of melasma during the study period of one year. Melasma area severity index (MASI) score was recorded for each patient. Melasma quality of life was evaluated using the Melasma related Quality of Life (MELASQOL) score. MASI score and MELASQOL score were correlated using the Chi square test and socio-demographic details were also recorded. Results: The mean MASI score in our study was 14.39 and the mean MELASQOL score was 34.98. The correlation of the MASI score with the MELASQOL score was found to be statistically significant (p value = 0.000). Conclusion: MELASQOL score can be used to assess the quality of life in patients with melasma and the impairment in quality of life depends upon the MASI score.

show abstract

“…In the study conducted by Sarkar et al, mean MASI score was 20. 10 We found a signifi cant rela! onship between the MASI score and occupa!…”

Section: Discussionmentioning

confidence: 74%

“…This fi nding is supported by the study conducted by Bha& arai et al, which showed epidermal preponderance (65.2%). 10 We assessed the severity of melasma in each pa! ent using the MASI score.…”

Section: Discussionmentioning

confidence: 99%

Quality of life in Patients with Melasma: A Hospital-Based Study

Mainali¹,

Jha²,

Shrestha

et al. 2022

Nepal J Dermatol Venereol & Leprol

View full text Add to dashboard Cite

show abstract

“…Endocrine abnormalities involving ovaries along with their tumors and thyroid dysfunctions are also involved. External agents like cosmetic products, nutritional deficiencies, intake of photo allergic or phototoxic drugs and antiepileptic agents are some important factors associated with this pigmentary disorder 4 . During pregnancy certain hormone changes also contribute to development of melasma along with other normal physiological changes like darkening of the nipples and linea nigra.…”

Section: Introductionmentioning

confidence: 99%

Comparison of 4% Topical Hydroquinone versus Combination of Oral Tranexamic Acid and 4% Topical Hydroquinone in the Treatment of Epidermal Melasma

Riaz¹,

Ahmed²,

Anwar³

et al. 2021

PJMHS

View full text Add to dashboard Cite

Objective: comparison of efficacy of topical 4% hydroquinone monotherapy with combination of oral tranexamic acid and topical 4% hydroquinone in the treatment of epidermal melasma Study design: Quasi experimental study Study period and place: Dermatology OPD, Pak Emirates Military Hospital Rawalpindi from July 2018 to January 2019. Methodology: Total 80 patients presenting with epidermal melasma were selected from outdoor patient department after applying the inclusion criteria and consent was taken from selected patients. Study was started after getting permission from hospital ethical review board. Two treatment groups were made after dividing patients by using alternate method. Treatment with topical 4% hydroquinone alone was started for group A patients and combination of capsule tranexamic acid (250 mg two times a day) along with topical 4% hydroquinone were started for group B patients for the next 6 months. Evaluation of patients through detailed history, clinical and wood’s light examination before starting therapy and after of 24 weeks of treatment was done for both groups. Efficacy of treatment was assessed via Modified MASI score. Results: Hydroquinone monotherapy was effective in 21 (52.5%) patients among group A while in group B patients, combination treatment i.e. oral tranexamic acid and topical hydroquinone, was effective in 31 (77.5%) patients (p value= 0.01). Conclusion: Effectiveness of Hydroquinone 4% topical therapy combined with oral tranexamic acid for epidermal melasma is better than topical 4% hydroquinone alone. Key words: Epidermal melasma, oral tranexamic acid, topical 4% hydroquinone.

show abstract

Clinical patterns and epidemiological characteristics of melasma in a tertiary care hospital of Nepal

Cited by 2 publications

References 0 publications

Quality of life in Patients with Melasma: A Hospital-Based Study

Quality of life in Patients with Melasma: A Hospital-Based Study

Comparison of 4% Topical Hydroquinone versus Combination of Oral Tranexamic Acid and 4% Topical Hydroquinone in the Treatment of Epidermal Melasma

Contact Info

Product

Resources

About