Clinical pathology of Schistosoma bovis infection in goats

Monrad, J.; Christensen, N. Ø.; Nansen, P.; Frandsen, Flemming

doi:10.1016/s0034-5288(18)30484-3

Cited by 17 publications

(9 citation statements)

References 7 publications

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“…Unlike cattle , we have no evidence of the development of a naturallyacquired resistance following repeated contacts in the fields; on the contrary, a field survey on sheep in Sudan showed an increasing prevalence and intensity of infection with S. bovis related to the duration of infecting contacts . Although the pathogenesis of S. bovis has already been investigated in small ruminants (Saad et al 1984, Kassuku et al 1986, basic studies on their immune responses to experimental infection are urgently needed and would be of great interest in the context of comparative immunology.…”

Section: Discussionmentioning

confidence: 99%

Vaccination of goats against the trematode Schistosoma bovis with a recombinant homologous schistosome‐derived glutathione S‐transferase

Boulanger

Trottein

Mauny

et al. 1994

Parasite Immunology

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We assayed the vaccine potentialities of a recombinant S. bovis-derived glutathione S-transferase (rSb28GST), member of a molecular family already shown to have protective capacities in the S. mansoni and S. japonicum models. Injection of the rSb28GST in Freund's Complete Adjuvant resulted in good specific IgG responses allowing all the animals to display high antibody titres on the day of experimental challenge with S. bovis cercariae. No statistically significant differences were observed in the faecal egg output. Although tissue egg counts in vaccinated animals were lower than in controls, the difference was not statistically significant, apart from the number of eggs trapped in the liver (P < 0.05). Likewise, PCV values remained parallel between the two groups. However, immunized goats gained 1.4 kg of body weight throughout the experiment whereas controls lost 1.2 kg (P < 0.05). In addition, the mean worm burden, assessed by perfusion 20 weeks after infection, was significantly reduced by 48% in the vaccinated group, the sex ratio being unaffected. It appears that a recombinant homologous protein can affect, in a natural host, the course of an experimental infection with a local strain of S. bovis, by affecting worm viability but not fecundity. These results also point to the striking differences in the effect of vaccination according to animal species. Because it has the capacity to prevent growth impairment due to schistosome pathogenicity, the molecule can be proposed as a valuable tool in the development of vaccine-based control programs in endemic areas.

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Section: Discussionmentioning

confidence: 99%

Vaccination of goats against the trematode Schistosoma bovis with a recombinant homologous schistosome‐derived glutathione S‐transferase

Boulanger

Trottein

Mauny

et al. 1994

Parasite Immunology

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“…Trematode infections in domestic ruminants caused by Fasciola gigantica, Fasciola hepatica, paramphistomes, Schistosoma bovis and Dicrocoelium hospes are known to be present in Tanzania (Mahlau, 1970;Hyera, 1984;Kassuku et al 1986;Keyyu et al 2005;Walker et al2008) and are considered to be major constraints to cattle production (Mwabonimana et al 2009;Swai and Ulicky, 2009;Mellau et al 2010;Komba et al 2012;Nzalawahe and Komba, 2013;Nzalawahe et al 2014). In Kenya, deliberate infection of Boran cattle with F. gigantica metacercariae caused production losses from the combination of liver condemnations and reduction in liveweight gain to the value of US$23.41 (10.34%) per head (Wamae et al 1998).…”

Section: Introductionmentioning

confidence: 99%

“…The other areas that have been reported to favour the occurrence of trematode infections includes wet and humid areas (Majok et al 1993) and areas with high stocking rate of animals (Cheruiyot, 1983). Previous epidemiological studies of trematode infections in cattle (Kassuku et al 1986;Makundi et al 1998;Keyyu et al 2005) in Iringa Rural District were primarily conducted in the highlands (altitude ~1500 m) which are characterized with high annual rainfall, and wet grazing lands (Makundi et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Associations between trematode infections in cattle and freshwater snails in highland and lowland areas of Iringa Rural District, Tanzania

et al. 2015

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The epidemiology of trematode infections in cattle was investigated within highland and lowland areas of Iringa Rural District, in southern Tanzania. Fecal samples were collected from 450 cattle in 15 villages at altitudes ranging from 696 to 1800 m above the sea level. Freshwater snails were collected from selected water bodies and screened for emergence of cercariae. The infection rates in cattle were Fasciola gigantica 28·2%, paramphistomes 62·8% and Schistosoma bovis 4·8%. Notably, prevalence of trematode infections in cattle was much higher in highland (altitude > 1500 m) as compared with lowland (altitude < 1500 m) areas and was statistically significant (P-value = 0·000) for F. gigantica and paramphistomes but not for S. bovis. The snails collected included Lymnaea natalensis, Bulinus africanus, Bulinus tropicus, Bulinus forskali, Biomphalaria pfeifferi, Melanoides tuberculata and Bellamya constricta with a greater proportion of highland (75%) than lowland (36%) water bodies harbouring snails. Altitude is a major factor shaping the epidemiology of F. gigantica and paramphistomes infections in cattle in Iringa Rural District with greater emphasis upon control needed in highland areas.

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“…The economic importance of schistosomiasis to livestock farmers is suspected to be high, although there are substantially fewer data available on the economic impact of schistosomiasis in animals or the cost-effectiveness of their treatment. Helminth infections of ruminants are widely acknowledged as a constraint on efficient livestock production systems globally 18 and there is some literature available documenting the pathological effects of schistosome infection in animals, such as of S. mattheei in cattle, 19 S. bovis in goats 20 and S. curassoni in sheep. 21 Productivity losses may include mortality of infected animals, growth delay, reduced meat and milk quantity and quality, and poor future reproductive capacity.…”

Section: Introductionmentioning

confidence: 99%

Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock

Gower

Vince

Webster

2017

Transactions of the Royal Society of Tropical Medicine and Hygiene

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A One Health economic perspective allows informed decisions to be made regarding control priorities and/or implementation strategies for infectious diseases. Schistosomiasis is a major and highly resilient disease of both humans and livestock. The zoonotic component of transmission in sub-Saharan Africa appears to be more significant than previously assumed, and may thereby affect the recently revised WHO vision to eliminate schistosomiasis as a public health problem by 2025. Moreover, animal schistosomiasis is likely to be a significant cost to affected communities due to its direct and indirect impact on livelihoods. We argue here for a comprehensive evaluation of the economic burden of livestock and zoonotic schistosomiasis in sub-Saharan Africa in order to determine if extending treatment to include animal hosts in a One Health approach is economically, as well as epidemiologically, desirable.

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Clinical pathology of Schistosoma bovis infection in goats

Cited by 17 publications

References 7 publications

Vaccination of goats against the trematode Schistosoma bovis with a recombinant homologous schistosome‐derived glutathione S‐transferase

Vaccination of goats against the trematode Schistosoma bovis with a recombinant homologous schistosome‐derived glutathione S‐transferase

Associations between trematode infections in cattle and freshwater snails in highland and lowland areas of Iringa Rural District, Tanzania

Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock

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