Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma
Kate I. Silver,
Joshua D. Mannheimer,
Corey Saba
et al.
Abstract:Appendicular osteosarcoma was diagnosed and treated in a pair of littermate Rottweiler dogs, resulting in distinctly different clinical outcomes despite similar therapy within the context of a prospective, randomized clinical trial (NCI-COTC021/022). Histopathology, immunohistochemistry, mRNA sequencing, and targeted DNA hotspot sequencing techniques were applied to both dogs’ tumors to define factors that could underpin their differential response to treatment. We describe the comparison of their clinical, hi… Show more
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