Clinical parameters in male genital lichen sclerosus: a case series of 329 patients

Edmonds, E. V. J.; Hunt, Sharon A.; Hawkins, David; Dinneen, M; Francis, N.; Bunker, C.B.

doi:10.1111/j.1468-3083.2011.04155.x

Cited by 151 publications

(265 citation statements)

References 47 publications

(152 reference statements)

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“…A review of the literature highlighted that steroids, considered the gold standard for treating LS, were effective only for short periods of time and featured a high percentage of relapses during the long-term follow-up period (50-80%) [18,19,20]. Chronic treatment with a steroid could moreover cause serious side effects that at times were even serious, such as skin atrophy, rebound effects, fungal infections, re-activation of the papilloma virus (HPV), infections due to the Herpes simplex virus and systemic absorption [24,29].…”

Section: Discussionmentioning

confidence: 99%

“…Other triggering factors could consist of some infectious agents (Borrelia) or traumatic events and/or outcomes of genital surgery [11,12,13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

“…The standard pharmacological treatment is based on the use of topical steroids, which have proved their efficacy in 60-70% of cases but with a high rate of relapses in time (50-80% of the patients of both sexes) [18,19,20]. The topical calcineurin inhibitors pimecrolimus and tacrolimus have a significant anti-inflammatory activity, immunomodulatory effects and a low systemic immunosuppressive potential; however, they are off-label and considered dangerous to develop tumours [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Zucchi¹,

Cai²,

Cavallini³

et al. 2016

Urol Int

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Lichen sclerosus (LS) is an inflammatory and chronic disease that causes itching, pain, dysuria, urinary retention, dyspareunia and sexual dysfunction, in both men and women. The first line pharmacological treatment is based on the use of topical steroids, which have proved their efficacy in 60-70% of cases but with a high rate of relapses in time (50-80% of the patients of both sexes). The purpose of our non-randomised prospective pilot study was to evaluate the efficacy and tolerability of a new loco regional therapy with polydeoxyribonucleotides (PDRN) in the treatment of male genital LS. PDRN is an healing and anti-dystrophic drug with anti-inflammatory effects, through the reduction of cytokine. Twenty one male patients suffering from genital LS were recruited. All the patients were submitted to treatment using loco-regional intradermal injections with PDRN. Dermatology Life Quality Index (DLQI), International Index of Erectile Function (IIEF-5) and PGI-I questionnaires were administered at baseline and at the end of treatment in order to evaluate the results of this treatment. The statistical evaluation of the data obtained with the DLQI questionnaire showed a marked improvement of the overall conditions in terms of quality of life, with an average change of scores from 15 to 4 (p < 0.0001). PGI-I questionnaire showed that 80% of the patients treated considered their post-treatment conditions as ‘improved'. There was no significant change in terms of sexual function according to the IIEF questionnaire (p = 0.189). The results obtained show the excellent tolerability and the therapeutic efficacy of PDRN, with clear improvement of the local symptoms and of the quality of life.

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Section: Discussionmentioning

confidence: 99%

“…Other triggering factors could consist of some infectious agents (Borrelia) or traumatic events and/or outcomes of genital surgery [11,12,13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Zucchi¹,

Cai²,

Cavallini³

et al. 2016

Urol Int

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“…Najnowsze badania kładą jednak nacisk na wpływ innych czynników związanych ze wzrostem ryzyka zachorowania na LS [16][17][18]. Część autorów uważa, że miejscowy uraz i zaleganie moczu są ważnymi czynnikami wybitnie zwiększającymi możliwość wystąpienia LS [12,[19][20][21]. Inne stany również wpływa-ją na zwiększenie ryzyka zapadalności na LS.…”

Section: Obraz Klinicznyunclassified

Current views on the diagnosis and treatment of genital lichen sclerosus

Pniewski¹,

Smolarczyk²,

Sałkowska-Wanat³

et al. 2016

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“…The underlying cause is unknown (19), but it has been frequently associated with phimosis, either as a cause or as a consequence (17,20).…”

Section: Lichen Sclerosusmentioning

confidence: 99%

Prevalence and risk factors for penile lesions/anomalies in a cohort of Brazilian men â‰¥ 40 years of age

Romero¹,

Romero²,

Almeida

et al. 2013

Int. braz j urol.

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Purpose: To report the prevalence and risk factors of penile lesions/anomalies in a Metropolitan Brazilian city. Materials and Methods: All participants undergoing prostate cancer screening in the city of Curitiba were systematically examined to identify penile lesions including cutaneous mycosis, sexually transmitted diseases, penile cancer, meatal stenosis, hypospadias, and Peyronie's disease. Outcomes of interest included the prevalence and the relative risk and 95% confidence intervals of the lesions/anomalies according to age, school level, race, personal history of diabetes, arterial hypertension, nonspecific urethritis, and vasectomy. Results: Balanoposthitis occurred in 11.8% of all participants, with an increased risk in those with diabetes (RR = 1.73), or past history of nonspecific urethritis (RR = 1.58); tinea of the penis was present in 0.2%; condyloma acuminata in 0.5%; herpes virus infection in 0.4%; urethral discharge in 0.2%; genital vitiligo in 0.7%, with an increased prevalence in non-white men (RR = 4.43), and in subjects with lower school level (RR = 7.24); phimosis in 0.5%, with a nearly 7-fold increased risk in diabetics; lichen sclerosus in 0.3%; stenosis of the external urethral meatus in 0.7%, with a higher prevalence in subjects with lichen sclerosus (RR = 214.9), and in those older than 60 years of age (RR = 3.57); hypospadia in 0.6%; fibrosis suggestive of Peyronie's disease in 0.9%, especially in men older than 60 years (RR = 4.59) and with diabetes (RR = 3.91); and penile cancer in 0.06%. Conclusion: We estimated the prevalence and risk factors of commonly seen penile diseases in an adult cohort of Brazilian men.

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Clinical parameters in male genital lichen sclerosus: a case series of 329 patients

Cited by 151 publications

References 47 publications

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Genital Lichen Sclerosus in Male Patients: A New Treatment with Polydeoxyribonucleotide

Current views on the diagnosis and treatment of genital lichen sclerosus

Prevalence and risk factors for penile lesions/anomalies in a cohort of Brazilian men â‰¥ 40 years of age

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