Clinical Overlap among Familial Subtypes of Unipolar Depression

Béhar, David; Winokur, George; Valkenburg, Charles Van; Lowry, Michael; Lachenbruch, Peter A.

doi:10.1159/000117848

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…However, these investigators found no differences between patients who were positive and negative for family history with respect to life events three months prior to onset of the depression. Similarly, McGuffin et al (1988) were unable to confirm the predicted “inverse association between the presence of familial loading and reactivity to stress” (p. 775; see also Behar et al, 1981; Thomson & Hendrie, 1972). …”

Section: Life Stress and Family History For Depression: The Moderatinmentioning

confidence: 96%

Life stress and family history for depression: The moderating role of past depressive episodes

Monroe

Slavich

Gotlib

2014

Journal of Psychiatric Research

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Three of the most consistently reported and powerful predictors of depression are a recent major life event, a positive family history for depression, and a personal history of past depressive episodes. Little research, however, has evaluated the inter-relations among these predictors in depressed samples. Such information is descriptively valuable and potentially etiologically informative. In the present article we summarize the existing literature and test four predictions in a sample of 62 clinically depressed individuals: (1) participants who experienced a major life event prior to onset would be less likely than participants who did not experience a major life event to have a positive family history for depression; (2) participants with a recent major life event would have fewer lifetime episodes of depression than would participants without; (3) participants with a positive family history for depression would have more lifetime episodes of depression than would participants with a negative family history for depression; and (4) we would obtain a 3-way interaction in which participants with a positive family history and without a major life event would have the most lifetime episodes, whereas participants with a negative family history and a major life event would have the fewest lifetime episodes. The first three predictions were confirmed, and the fourth prediction partially confirmed. These novel findings begin to elucidate the complex relations among these three prominent risk factors for depression, and point to avenues of research that may help illuminate the origins of depressive episodes.

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Section: Life Stress and Family History For Depression: The Moderatinmentioning

confidence: 96%

Life stress and family history for depression: The moderating role of past depressive episodes

Monroe

Slavich

Gotlib

2014

Journal of Psychiatric Research

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“…Winokur and associates [van Valkenburg et al, 1977;Behar et al. 1981] have discussed this problem at some length, and have pointed out that when the presence of a certain number and type of symptoms are required to assign a patient to a certain major category of psychiatric disorder, then it becomes difficult to evidentiate differ ences among subgroups.…”

mentioning

confidence: 99%

Attempts to Validate a Classification of Unipolar Depression Based on Family Data

Perris¹,

Eisemann²,

Ericsson³

et al. 1983

Neuropsychobiology

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162 depressed patients, consecutively admitted to the Department of Psychiatry, Umeå University, were rated by means of the comprehensive psychopathological rating scale (CPRS) within a few days after their admission, and before any antidepressive treatment had been implemented. The same patients were later subdivided into groups according to the presence or absence of psychiatric illness among their first-degree relatives. Four groups were thus formed: depression pure disease (DPD), i.e., comprised of patients with only secondary cases of depression; depression spectrum disease (DSD), comprised of patients with secondary cases of both depression and alcoholism and antisocial personality among their first-degree relatives; positive family history-others (FH+.O), included those patients with first-degree relatives affected by other psychiatric disorders than those required for inclusion among the DSD; and finally, sporadic depression (SD), comprised of those patients who had no family loading at all. The results showed that the severity of illness was similar in all four groups. Only a few symptomatological differences emerged, and these related consistently to a higher frequency of symptoms of retardation (inability to feel, lassitude, and concentration difficulties) in the DSD group as compared to the SD group. No significant symptomatological differences occurred between patients in the DPD and DSD groups. It is concluded that a classification of unipolar patients based on family data does not predict the occurrence of various symptomatological patterns.

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The Validity of Neurotic-Reactive Depression

Winokur¹

1985

Arch Gen Psychiatry

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Clinical Overlap among Familial Subtypes of Unipolar Depression

Cited by 7 publications

References 4 publications

Life stress and family history for depression: The moderating role of past depressive episodes

Life stress and family history for depression: The moderating role of past depressive episodes

Attempts to Validate a Classification of Unipolar Depression Based on Family Data

The Validity of Neurotic-Reactive Depression

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