Clinical outcomes using a faecal immunochemical test for haemoglobin as a first‐line test in a national programme constrained by colonoscopy capacity

Steele, Robert; McDonald, Paul C.; Digby, Jayne; Brownlee, Linda; Strachan, J; Libby, Gillian; McClements, Paula L.; Birrell, Janice; Carey, Francis A.; Diament, R. H.; Balsitis, M; Fraser, Callum G.

doi:10.1177/2050640613489281

Cited by 68 publications

(78 citation statements)

References 21 publications

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“…This can be explained by the fact that CRC incidence is lower in Serbia than in other West European countries. The PPV for carcinoma was 14.6%, which is higher than that in studies that used FIT (Parente et al, 2009;Binefa et al, 2013;Steele et al, 2013). We can surmise that this higher percentage is because of the fact that this was the first screening programme in Serbia.…”

Section: Discussioncontrasting

confidence: 71%

Faecal occult blood screening for colorectal cancer in Serbia: a pilot study

Šćepanović

Jovanović²,

Keber

et al. 2017

European Journal of Cancer Prevention

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Colorectal cancer (CRC) is becoming a major public health problem in the Republic of Serbia. Organized mass screening has been shown to decrease CRC mortality and even its incidence. The aim of this study was to assess the acceptability of a faecal immunochemical test for haemoglobin proposed by primary care physicians. From August to November 2013, a pilot study for CRC screening was organized in individuals aged 50 to 74 years. The study included 50 primary healthcare centres from all 25 administrative regions of Serbia. A qualitative immunochromatographic faecal immunochemical test for human haemoglobin detection was used. Overall, 50 894 individuals were invited. The participation rate was 67.8 and 3.4% of the tests were positive. Among individuals with a positive test, 69.7% agreed to undergo colonoscopy. The positive predictive value was 27.1% for adenoma and 14.6% for carcinoma. This was the first CRC screening project encompassing approximately one-third of primary healthcare facilities in all regions across the country. It showed a good response of the target population and satisfactory cooperation of the healthcare professionals involved.

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Section: Discussioncontrasting

confidence: 71%

Faecal occult blood screening for colorectal cancer in Serbia: a pilot study

Šćepanović

Jovanović²,

Keber

et al. 2017

European Journal of Cancer Prevention

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“…10 In our assessment of a recent evaluation of FIT as a first-line test in two rather different NHS Boards in Scotland (NHS Tayside and NHS Ayrshire & Arran), we documented and compared uptake with that obtained contemporaneously in two other NHS Boards (NHS Fife and NHS Forth Valley), selected for their similarity to NHS Tayside and NHS Ayrshire & Arran, respectively, and also before and after the evaluation in all four NHS Boards. 11 The overall uptake in the two evaluation NHS Boards that participated in the study rose by 5.2% and 6.0% during the use of FIT, but then fell to values similar to those previously seen when the current gFOBT/FIT algorithm used in Scotland 12 was reinstituted. The two NHS Boards in which FIT was not used had small, random changes in uptake over time, but did not have the important rise in participation seen with use of FIT.…”

Section: Introductionmentioning

confidence: 80%

“…In addition, data on uptake for the FIT was from participants in two NHS Boards, whereas the data for gFOBT was from nine NHS Boards. As described previously 11 , we have compared the overall uptake of FIT with that of gFOBT in detail in four NHS Boards contemporaneously over four six month periods. Detailed exploration and comparison of the sex, age, and deprivation characteristics in participants in all four NHS Boards would have been of much interest, however, the detailed data required for this were unavailable from our two comparative participants in NHS Fife and NHS Forth Valley.…”

Section: Discussionmentioning

confidence: 99%

“…11,15,16 All individuals aged 50 to 74 in the two evaluation NHS Boards eligible to participate from 1 July 2010 to 12 January 2011 were sent an invitation pack. This contained an invitation letter, a "Know the Facts" leaflet on bowel cancer, a thin card wallet with printed written and pictorial instructions for specimen collection from a single faeces sample, a specimen collection device taking 10 mg faeces into 2.0 ml preservative buffer (Eiken Chemical Co., Tokyo, Japan), and a small zip-lock plastic bag containing absorbent material.…”

Section: Methodsmentioning

confidence: 99%

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Use of a faecal immunochemical test narrows current gaps in uptake for sex, age and deprivation in a bowel cancer screening programme

Digby

McDonald²,

Strachan³

et al. 2013

J Med Screen

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Objectives To investigate the characteristics of participants screened for bowel cancer using a faecal immunochemical test for haemoglobin (FIT). Setting Scottish Bowel Screening Programme. Methods 65909 men and women in two NHS Boards, aged 50 to 74, were invited to participate in an evaluation of FIT as a first-line test. Uptake was calculated by sex, age in quintiles, and deprivation in quintiles, and compared with a group who had completed a guaiac faecal occult blood test (gFOBT) and for whom details of sex, age and deprivation were well documented. Results FIT kits from 38672 participants were tested. The overall uptake of 58.7% was significantly higher than the 53.9% for gFOBT (p , 0.0001). Uptakes in the two NHS Boards were 57.6% and 54.4% for men and 63.2% and 59.1% for women, higher than the 49.5% and 58.1% completing gFOBT. Uptake was higher for FIT than gFOBT in all age and deprivation quintiles for both men and women in both NHS Boards. The difference in uptake fell with age for men but rose for women; the increase in uptake was greater for men than women. Uptake fell as deprivation decreased for both sexes, and was similar in both NHS Boards. Conclusions Use of FIT increases uptake over gFOBT, and the greatest increases are seen in men, younger participants, and more deprived individuals, groups for which an increase in uptake is likely to be beneficial. The results support a move to FIT as a first-line screening test for those countries still using gFOBT.

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“…7,8 Some countries still use guaiac-based fecal test as the initial screening test, but all are planning to adopt FIT in the future. 9 However, there still exist 2 controversies with respect to the accuracy of FIT in different circumstances. The first regards the diagnostic performance of FIT in the detection of proximal vs distal neoplasia.…”

mentioning

confidence: 99%

Diagnostic Accuracy of a Qualitative Fecal Immunochemical Test Varies With Location of Neoplasia But Not Number of Specimens

Wong

Ching

Chan

et al. 2015

Clinical Gastroenterology and Hepatology

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Clinical outcomes using a faecal immunochemical test for haemoglobin as a first‐line test in a national programme constrained by colonoscopy capacity

Abstract: In summary, this evaluation of the FIT supports the introduction of FIT as a first-line test, even when colonoscopy capacity is limited.

Cited by 68 publications

References 21 publications

Faecal occult blood screening for colorectal cancer in Serbia: a pilot study

Faecal occult blood screening for colorectal cancer in Serbia: a pilot study

Use of a faecal immunochemical test narrows current gaps in uptake for sex, age and deprivation in a bowel cancer screening programme

Diagnostic Accuracy of a Qualitative Fecal Immunochemical Test Varies With Location of Neoplasia But Not Number of Specimens

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