Clinical Outcomes of Trabeculectomy with Amniotic Membrane Transplantation and Mitomycin C in Primary Open-Angle Glaucoma

Moon, Sangwoo; Lee, Jiwoong

doi:10.3341/jkos.2020.61.8.929

Cited by 2 publications

(4 citation statements)

References 40 publications

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“…The amniotic membrane has anti-scarring and anti-inflammatory properties in fibrotic eye disease, including glaucoma surgery [ 10 – 12 , 37 , 38 ]. The anti-scarring effect of the amniotic membrane is mediated by downregulating TGF-β signalling pathway and myofibroblast differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that trabeculectomy with amniotic membrane transplantation (AMT) had a lower complication rate and higher success rate than trabeculectomy without AMT [ 10 – 12 ]. In our previous study, trabeculectomy with AMT was found to be a safe and effective method for intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG) without the development of avascular cystic blebs or bleb-related infection [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Intrableb Characteristics of Anterior Segment Optical Coherence Tomography Imaging in Trabeculectomy according to Amniotic Membrane Transplantation

Moon¹,

Kim²,

Lee³

2023

Ophthalmic Res

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Introduction: The purpose of this study was to compare the characteristics of filtering bleb with anterior segment optical coherence tomography (AS-OCT) according to amniotic membrane transplantation (AMT). Methods: One hundred and sixteen eyes of 103 glaucoma patients who underwent trabeculectomy with (AMT group; 85 eyes) or without AMT (control group; 31 eyes) were included. Intrableb parameters were evaluated with AS-OCT. Surgical success was defined as an intraocular pressure (IOP) ≤18 mm Hg and IOP reduction ≥20% without medication at the time of AS-OCT examination. Logistic regression analyses were performed to determine factors associated with IOP control. Results: In the eyes with successful IOP control, the fluid-filled space area, score, and height were greater for the AMT group than the control group (all ps < 0.001), while stripping layer thickness was greater and bleb wall reflectivity was lower for the control group than the AMT group (all ps < 0.001). Surgical success in the AMT group was associated with greater fluid-filled space score, lower bleb wall reflectivity, and microcyst formation (odds ratio [OR] = 8.016, 0.913, and 16.202, respectively, all ps ≤ 0.041). Lower bleb wall reflectivity alone was associated with surgical success in the control group (OR = 0.815, p = 0.019). Conclusion: The extent of the fluid-filled space was associated with successful IOP control after trabeculectomy with AMT. Hyporeflective bleb wall was associated with successful IOP control in AMT and control groups.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Intrableb Characteristics of Anterior Segment Optical Coherence Tomography Imaging in Trabeculectomy according to Amniotic Membrane Transplantation

Moon¹,

Kim²,

Lee³

2023

Ophthalmic Res

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“…Trabeculectomy with amniotic membrane transplantation (AMT) above or under the scleral flap had a high success rate and fewer complications [ 10 – 12 ]. We previously evaluated the effect of AMT on trabeculectomy and found that it was a safe and effective procedure for intraocular pressure (IOP) reduction in patients with primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma [ 13 , 14 ]. Furthermore, the incidence of avascular blebs was significantly lower in the AMT group than in the control group.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the incidence of avascular blebs was significantly lower in the AMT group than in the control group. The transplanted amniotic membrane may act as part of the bleb wall and relieve pressure on it [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Bleb analysis using anterior segment optical coherence tomography after trabeculectomy with amniotic membrane transplantation

et al. 2023

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Introduction Little has been known about the intrableb structures associated with bleb function after trabeculectomy with amniotic membrane transplantation (AMT). The aim of this study is to analyze the characteristics of intrableb structures using anterior segment optical coherence tomography (AS-OCT) after trabeculectomy with AMT. Methods A total of 68 eyes of 68 patients with primary open-angle glaucoma who underwent trabeculectomy with AMT were included. Surgical success was defined as intraocular pressure (IOP) ≤ 18 mmHg and IOP reduction of ≥ 20% without medication on AS-OCT examination. Intrableb parameters, including bleb height, bleb wall thickness, striping layer thickness, bleb wall reflectivity, fluid-filled space score, fluid-filled space height, and microcyst formation were evaluated using AS-OCT. Logistic regression analysis was performed to determine factors associated with IOP control. Results Of the 68 eyes, 56 eyes were assigned to the success group and 12 eyes to the failure group. In the success group, bleb height (P = 0.009), bleb wall thickness (P = 0.001), striping layer thickness (P = 0.001), fluid-filled space score (P = 0.001), and frequency of microcyst formation (P = 0.001) were greater than those in the failure group. Bleb wall reflectivity was higher in the failure group than in the success group (P < 0.001). In the univariate logistic regression analysis, previous cataract surgery was significantly associated with surgical failure (odds ratio = 5.769, P = 0.032). Conclusion A posteriorly extending fluid-filled space, tall bleb with low reflectivity, and thick striping layer were characteristics of successful filtering blebs after trabeculectomy with AMT.

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Clinical Outcomes of Trabeculectomy with Amniotic Membrane Transplantation and Mitomycin C in Primary Open-Angle Glaucoma

Cited by 2 publications

References 40 publications

Comparison of the Intrableb Characteristics of Anterior Segment Optical Coherence Tomography Imaging in Trabeculectomy according to Amniotic Membrane Transplantation

Comparison of the Intrableb Characteristics of Anterior Segment Optical Coherence Tomography Imaging in Trabeculectomy according to Amniotic Membrane Transplantation

Bleb analysis using anterior segment optical coherence tomography after trabeculectomy with amniotic membrane transplantation

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