This study aimed to assess the clinical efficacy of intravascular ultrasound (IVUS)-guided intraplaque wiring for femoropopliteal (FP) chronic total occlusion (CTO).Methods: This single-center, retrospective, observational study was performed at the Japanese Red Cross Kyoto Daini Hospital. From March 2013 to June 2017, a total of 75 consecutive patients (mean age: 75.4 8.5 years; 59 males), who underwent endovascular treatment (EVT), having 82 de novo FP-CTO lesions, were enrolled in this study. Eleven of the lesions that met the exclusion criteria were excluded, and the remaining 71 lesions were divided into the IVUS-guided wiring group (n 34) and non-IVUS-guided wiring group (n 37). Primary patency, defined as a peak systolic velocity ratio of 2.4 on duplex ultrasonography, and freedom from clinically driven target lesion revascularization (CD-TLR) at 12 months were the primary outcomes.
Results:The mean lesion length was 21.6 8.9 cm. The frequencies of primary patency and freedom from CD-TLR were significantly higher in the IVUS-guided wiring group than in the non-IVUS-guided wiring group (70.0% vs. 52.2%, p 0.045; 83.9% vs. 62.8%, p 0.036, respectively). The complete clinically true lumen angioplasty rate was also higher in the IVUS-guided wiring group than in the non-IVUS-guided wiring group (91.1% vs. 51.3%, p 0.001, respectively). The clinically true and false wire passage rates were respectively 97.3% and 2.7% in the IVUS-guided wiring group.
Conclusion: IVUS-guided wiring improves the clinical outcomes of EVT for FP-CTO by achieving a high clinically true lumen wire passage rate.CTO lesions compared with the subintimal approach 2-4) . Recently, Kawasaki et al. proposed that CTO wire passage routes should be classified into the intraplaque, subintimal, and intramedial routes based on intravascular ultrasound (IVUS) examinations (Fig. 1) 5) . They demonstrated that attempts to perform the wire loop technique with a 0.035 inch guidewire via the subintimal approach did not always result in the subintimal or intramedial route being taken. Conversely, Mori et al. reported that attempts to perform the drilling technique using a 0.014 inch guide-Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.