“…In particular, subjects with prior sternotomy, cardiac surgery, history of chest radiotherapy, and severe lung disease have been excluded from these primary phases of the study, whereas these are generally not uncommon features of patients undergoing ICD placement. 18 Therefore, larger studies are needed to provide a more comprehensive safety and efficacy profile of the EV-ICD lead implantation procedure in these specific settings. Another limitation of the study was its predominantly male cohort, which may not accurately reflect the sex distribution among patients who require ICD therapy in real-world clinical practice and may not elucidate potential procedural divergences due to anatomic differences.…”