Clinical outcomes of personalized frozen-thawed embryo transfer timing for patients with recurrent implantation failure

Abstract

Background: Recurrent implantation failure (RIF) is a critical problem for assisted reproduction technology. High-quality embryos and the synchronization endometrium both have great significance. How to get the optimal endometrial receptivity is a challenge for implantation and pregnancy of infertile patients with RIF. The objective of this study is to investigate personalized protocol of frozen-thawed embryo transfer (FET) cycles, and its effect on clinical outcomes in patients with RIF.Methods: We chose 91 RIF patients from January 2017 to June 2019 in the Reproductive Medicine Center of the First Hospital of Lanzhou University. A total of 100 FET cycles were undertaken with a gonadotropinreleasing hormone agonist (GnRH-agonist) protocol combined with hormone replacement therapy (HRT) for endometrial preparation. The patients were divided into two groups: the routine group (cleavage embryo transferred at day 3 after luteal support) included 48 cycles; the personalized group included 52 cycles with delayed endometrial trigger and luteal support (the time of embryo transfer depended on the level of serum hormone and endometrial thickness). Results:The data showed the personalized group had longer time for endometrial preparation. On the day of embryo transfer, serum progesterone (P) and the E 2 /P ratio was significantly different compared with the routine group (P<0.05). The clinical pregnancy rate in the routine group was 35.42% (17/48) and 59.62% (31/52) in the personalized group (P<0.05). The abortion rate was not significantly different.Conclusions: For women with RIF, personalized timing for transfer of FET resulted in a higher clinical pregnancy rate compared with routine protocol.

Management of Recurrent Implantation Failure and Hereditary Thrombophilia: A Case Report

“…Ultimately, this case report underscores the efficacy of the combined utilization of PGT-A and ERA techniques in attaining live births in cases of patients with complicated medical histories (advanced age, hereditary thrombophilia homozygous mutation of the MTHFR genes, and RIF) [4,5].…”

Competent blastocyst and receptivity endometrium improved clinical pregnancy in fresh embryo transfer cycles: a retrospective cohort study

“…The success of ET relies on synchronization between the embryo and endometrium so that the endometrium is optimally receptive embryo implantation [ 9 , 29 ]. Previous studies had investigated that women with repeated implantation failure (RIF), and personalized transfer timing resulted in a higher clinical pregnancy rate compared with routine protocols [ 30 – 32 ]. Thus, although there is a benefit favoring blastocyst transfer in fresh cycles, it remains unclear whether the day of transfer impacts the pregnancy rate [ 4 ].…”

Association between Available Blastocyst Formation Rate and Pregnancy Outcome Following Fresh Embryo Transfer

“…The success of ET relies on synchronization between the embryo and endometrium so that the endometrium is optimally receptive for the embryo to implant [9,22]. Previous studies had investigated that women with repeated implantation failure (RIF), personalized timing for transfer resulted in a higher clinical pregnancy rate compared with routine protocol [23][24][25]. Thus, although there is a bene t favoring blastocyst transfer in fresh cycle, it remains unclear whether the day of transfer impacts on pregnancy rate [4].…”