Clinical outcomes of pandemic (H1N1) 2009 influenza (swine flu) in adults with cystic fibrosis

Impact of the A (H1N1) pandemic influenza (season 2009–2010) on patients with cystic fibrosis

“…However, since it is uncertain if additional waves will occur, countries should be prepared for a second wave of infection. Despite previous reports, including only a small number of patients, showing that A (H1N1) infection caused mild disease [17,18], this report demonstrates that viral infection is associated with increased morbidity, and in certain patients with mortality. We therefore recommend that patients with CF, their families and their health care providers be aware of the risks of infection.…”

“…Although vaccination is recommended, inadequate coverage has been reported [15,16]. Recent reports from Australia and the UK on a very small number of patients with CF infected with A (H1N1) virus reported a mild course of disease with complete recovery [17,18]. The present study was initiated when the World Health Organisation and the European health authorities declared the A (H1N1) pandemic.…”

Predicting the unpredictable: is it possible clinically to separate H1N1 from non-H1N1 community-acquired pneumonia?

“…In addition, the findings only apply to younger adults who predominantly made up the cohort of H1N1 pneumonia cases included in the study. The findings may not apply to children who have a very high incidence of infection or to other subgroups in which the clinical spectrum may be different, such as patients with cystic fibrosis (see letters by Colombo and Nash in this issue of Thorax ( see pages , )) 17 18. The virus is subject to constant antigenic change, so the clinical picture with future variants of the virus may not be the same and different age groups may be predominantly affected.…”

Viral Respiratory Tract Infections in Cystic Fibrosis

“…To date very little data exists regarding its impact on patients with CF. Nash et al (Nash, Whitmill et al 2011) showed the symptoms of CF patients infected with H1N1 tend to be mild. There was no significant reduction in FEV 1 % predicted, FVC % predicted and body mass index regardless of whether the patients were positive or negative for H1N1.…”