Clinical Outcomes of Omicron Variant (B.1.1.529) Infection in Children and Adolescents Hospitalized With COVID-19 in Brazil With Observational Data on the Efficacy of the Vaccines in Adolescents

Abstract

Oliveira et al responsibility for the integrity of the data and the accuracy of the data analysis. FIGURE 3. Predictors of death among 7442 participants who tested positive for SARS-CoV-2 during the omicronpredominant period. Data are from the competing-risk survival analysis (A) Model for the entire cohort, adjusted hazard ratios. (B) Model for individuals 12-19 years of age, adjusted hazard ratios. Error bars indicate 95% CI. Unvaccinated children were assigned as the reference category.

Seroprevalence of antibodies against SARS-CoV-2 in the school community in Campo Grande, state of Mato Grosso do Sul, Brazil, October 2021–November 2022

“…As in other studies ( 50 , 51 ), no statistical difference was found in seropositivity by sex, although women represented approximately 70% of the population tested ( Table 3 ). In addition, when estimating the seroprevalence in the different age groups according to the school level or the school type (i.e., municipal, state, or private), no statistical differences within each group were found ( Table 3 ).…”

“…Omicron presented greater humoral immune escape, thereby reducing the effectiveness of vaccines ( 48 , 49 ). Despite this increase in transmissibility, the indicators of clinical severity were higher for VOC Gamma, a variant prevalent in Mato Grosso do Sul from March to August 2021 ( 50 ). In addition, with the increase in the vaccination rate of the population, state and municipal government institutions in Brazil ceased to require the mandatory use of masks in public places, private establishments accessible to the public, and in public transportation.…”

Association of Prior COVID-19 Vaccination With SARS-CoV-2 Infection and Death in Children and Young Persons During the Omicron Variant Period in Brazil

“…Methods | We used a test-negative case-control design to analyze data between December 2021 and August 2022 during Omicron variant dominance. 2 Cases and controls were defined as individuals with a positive and negative test result for SARS-CoV-2 infection enrolled in the systems in the same time frame, respectively. The primary exposure of interest was vaccination status.…”

“…Rates of pediatric obesity reached unprecedented levels during the COVID-19 pandemic, 1 when children and adolescents experienced sudden changes to their routines, increased stress, and decreased opportunity for exercise and proper nutrition. 2 Pandemic burdens were greater for lowincome populations, 3 who are disproportionately affected by obesity. 4 We capitalized on the natural experiment of COVID-19 in the Adolescent Brain Cognitive Development (ABCD) Study, by comparing weight gain of participants (1-and 2-year follow-up assessments acquired before March 2020) with weight gain of participants whose 2-year followup occurred after the COVID-19 lockdown.…”