Clinical outcomes of ocular surface in patients treated with vitamin D oral
            replacement

Karaca, Emine Esra; Kemer, Özlem Evren; Özek, Dilay; Berker, Dilek; Imga, Narin Nasiroglu

doi:10.5935/0004-2749.20200043

Cited by 13 publications

(16 citation statements)

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“…Previous studies have demonstrated a relationship between deficient levels of vitamin D and onset or development of AMD [ 16 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], suggesting that vitamin D administration can be protective or preventive from progression to neovascular AMD. Recent studies have reported expression of vitamin D receptors throughout the eye, including the retina [ 31 , 32 ], where they are expressed by human retinal pigment epithelial cells (ARPE-19) [ 31 , 33 ] and retinal endothelial cells [ 34 ], suggesting vitamin D’s functional significance in the ocular system [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration

et al. 2021

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Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by dysfunction of retinal pigmented epithelial (RPE) and loss of photoreceptor cells under oxidative stress and inflammatory conditions. Vitamin D and antioxidants have beneficial effects against retinal degenerative diseases, such as AMD. We investigated the impact of associating vitamin D (ND) with a nutritional antioxidant complex (Nutrof Total®; N) on oxidative stress and inflammation-like induced conditions by H2O2 and LPS, respectively, in human retinal epithelial (ARPE-19) and human retinal endothelial (HREC) cells. Application of either N or ND treatments to H2O2-induced media in ARPE-19 cells counteracted late apoptosis, attenuated oxidative DNA damage, and increased cell proliferation. Significant reduction in the expression levels of MCP1, IL-8, and IL6 cytokines was observed following application of either N or ND treatments under LPS-induced conditions in ARPE-19 cells and in MCP-1 and IL12p70 cytokine levels in HREC cells. ND and not N revealed significant downregulation of IFNγ in ARPE-19 cells, and of IL-6 and IL-18 in HREC cells. In conclusion, adding vitamin D to Nutrof Total® protects in a synergistic way against oxidative and inflammatory stress-induced conditions in retinal epithelial and endothelial cells.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration

et al. 2021

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“…A previous case study reported that oral vitamin D supplementation ameliorated persistent symptoms in a 40-year-old patient with ocular pain, bilateral MGD, evaporative dry eye, and vitamin D deficiency [58]. A single-arm clinical study of 40 patients with vitamin D deficiency found that oral vitamin D supplementation for 8 weeks improved meibomian gland expressibility, eyelid margin condition, Schirmer's test value, FBUT, and subjective symptoms compared with baseline [19]. Eightweek topical application of an analog of the active form of vitamin D3 was also found to be associated with improved ocular symptoms, plugging and vascularity of lid margins, FBUT, corneal fluorescein staining, meibum grade, and meibomian gland area in patients with obstructive MGD [18].…”

Section: Discussionmentioning

confidence: 95%

“…Topical application of an analog of the active form of vitamin D3 was shown to ameliorate ocular symptoms and objective signs of MGD compared with baseline [18]. Oral vitamin D supplementation was also found to improve meibomian gland expressibility in MGD patients with vitamin D deficiency [19]. As far as we are aware, however, no observational study has previously examined the relationship between dietary intake of vitamin D and MGD.…”

Section: Introductionmentioning

confidence: 99%

Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study

Fukuoka

Arita

Mizoguchi³

et al. 2021

JCM

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Intervention studies have shown that n-3 polyunsaturated fatty acid (PUFA) supplementation is effective for the treatment of meibomian gland dysfunction (MGD). Ointment containing an analog of vitamin D has also been found to improve symptoms and signs of MGD. We have now evaluated the relation of MGD prevalence to dietary intake of fatty acids (FAs) and vitamin D among a Japanese population. Subjects comprised 300 adults aged 20 to 92 years residing on Takushima Island. MGD was diagnosed on the basis of subjective symptoms, lid margin abnormalities, and meibomian gland obstruction. Dietary FA and vitamin D intake was estimated with a brief-type self-administered diet history questionnaire. MGD prevalence was 35.3%. Multivariate adjusted odds ratios (95% confidence intervals) between extreme quintiles of intake for MGD prevalence were 0.40 (0.16–0.97) for total fat, 0.40 (0.17–0.97) for saturated FAs, 0.40 (0.17–0.97) for oleic acid, 0.52 (0.23–1.18) for n-3 PUFAs, 0.63 (0.27–1.49) for n-6 PUFAs, 1.32 (0.59–2.95) for the n-6/n-3 PUFA ratio, and 0.38 (0.17–0.87) for vitamin D. Total fat, saturated FA, oleic acid, and vitamin D intake may thus be negatively associated with MGD prevalence in the Japanese.

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“…27 Liu et al 21 suggested measuring the serum Vit-D levels for these patients and treating the Vit-D deficiency to prevent clinical and subclinical manifestations on the ocular surface. Karaca et al 28 reported an improvement in the functioning of the meibomian gland, the eyelid margin, Schirmer test measurement, TBUT, as well as subjective symptoms after 8 weeks of orally administered Vit-D supplementation in patients who had Vit-D deficiency. Bae et al 29 reported that an intramuscular injection of Vit-D in patients who have Vit-D deficiency improved the tear film parameters, including the TBUT, ocular surface staining, tear secretion, and lid margin hyperemia.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Histopathological Changes in Children With Vitamin D Deficiency

Aydemir¹,

İlhan²,

Pehlıvanoglu³

et al. 2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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The aim of this study was to investigate tear function-associated clinical findings and conjunctival histopathological changes in children with vitamin D (Vit-D) deficiency. Methods: This study used a prospective case-control design. Group 1 (n¼38) comprised pediatric patients with Vit-D deficiency, and group 2 (n¼45) was the control group. Tear break-up times (TBUTs), Schirmer-1 test measurements, ocular surface disease index (OSDI) scores, and conjunctival impression cytology (CIC) results of the groups were compared. Results: The participant demographic characteristics, including the mean age and the male-to-female ratio, were similar (P.0.05). The median TBUT and Schirmer-1 test measurement were 10 s (5-15) and 12 mm (6-19) in group 1 and 11 s (6-16) and 15 mm (8-21) in group 2 (P¼0.004 and P¼0.013, respectively). The median OSDI scores were 16 (10-20) in group 1 and 17 (10-21) in group 2 (P¼0.092). According to the CIC, 25 samples in group 1 and 40 samples in group 2 were categorized as grade 0, 11 samples in group 1 and 5 samples in group 2 were categorized as grade 1, and 2 samples in group 1 and no sample in group 2 were categorized as grade 2 (P¼0.027). Conclusion: Significant conjunctival histopathological changes occur in children with Vit-D deficiency, and these changes have effects on some tear function-associated clinical findings including the Schirmer-1 test and TBUT measurements.

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Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement

Cited by 13 publications

References 0 publications

Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration

Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration

Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado–Takushima Study

Conjunctival Histopathological Changes in Children With Vitamin D Deficiency

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