Clinical outcomes of non-alcoholic fatty liver disease:
Polish-case control study

Kempiński, Radosław; Łukawska, Agata; Krzyżanowski, Filip; Ślósarz, Dominika; Poniewierka, Elżbieta

doi:10.17219/acem/106173

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…Data on the association of diverticulosis and fatty liver disease are conflicting. While Bae et al and Kempinski et al showed a correlation between increasing levels of fatty liver and diverticulosis (moderate FLD (OR 2.238; 95% CI 1.026–4.882); severe FLD (OR 5.519; 95% CI 1.236–21.803)) [ 39 , 42 ], Sahin et al identified fatty liver disease as a negative predictor of diverticulosis (OR 0.529; 95% CI 0.323–0.866) [ 43 ]. Interestingly patients in the latter study were 65 years or older, while Bae et al and Kempinski et al included younger patients.…”

Section: Resultsmentioning

confidence: 99%

Diverticulosis and cardiometabolic risk factors: a systematic literature review

Völkerer,

Wernly,

Semmler

et al. 2023

Int J Colorectal Dis

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Background There is a hypothesis of an association between diverticulosis and metabolic syndrome (MS) or its components, but data on this topic are inconsistent, and a systematic review has not been performed. We conducted a systematic review to investigate the possible association between cardiometabolic risk factors and diverticulosis. Methods A systematic literature search was conducted via PubMed, Cochrane Library, and Web of Science in December 2022 to collect the necessary data. Studies that examined the association between MS or individual metabolic factors and asymptomatic diverticulosis were included in the review. Results Of the potentially relevant articles identified via PubMed (477), Cochrane Library (224), and Web of Science (296), 29 articles met the inclusion criteria and were used for this work. These studies were assessed for study quality using GRADE. Overall, 6 studies were rated as “very low,” 19 studies as “low,” and 4 studies as “moderate.” The data suggest an association between arterial hypertension, obesity, and fatty liver disease in younger patients and diverticulosis. Patient age appears to play an important role in diverticular formation. Data on diabetes mellitus is inconclusive and may require further investigation depending on the location of the diverticula. Conclusion Based on the synthesized data, there is an association between arterial hypertension, obesity, and fatty liver disease in younger patients. The formation of diverticula seems to be influenced by age and genetic factors. The study suggests a connection with cardiometabolic risk factors. To gain a better understanding of the role of metabolic risk factors in asymptomatic diverticulosis, targeted studies are necessary based on these findings.

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Section: Resultsmentioning

confidence: 99%

Diverticulosis and cardiometabolic risk factors: a systematic literature review

Völkerer,

Wernly,

Semmler

et al. 2023

Int J Colorectal Dis

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“…A meta-analysis showed that individuals with GERD had approximately twice the risk of developing NAFLD compared to those without GERD ( 12 ). A case–control study conducted in Poland also found a higher susceptibility of NAFLD among patients with GERD ( 34 ). GERD may promote the development of NAFLD through multiple mechanisms.…”

Section: Discussionmentioning

confidence: 97%

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Cao,

Jiang,

Zhang

et al. 2024

Front. Public Health

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BackgroundThe association between air pollution, lung function, gastroesophageal reflux disease, and Non-alcoholic fatty liver disease (NAFLD) remains inconclusive. Previous studies were not convincing due to confounding factors and reverse causality. We aim to investigate the causal relationship between air pollution, lung function, gastroesophageal reflux disease, and NAFLD using Mendelian randomization analysis.MethodsIn this study, univariate Mendelian randomization analysis was conducted first. Subsequently, Steiger testing was performed to exclude the possibility of reverse association. Finally, significant risk factors identified from the univariate Mendelian analysis, as well as important factors affecting NAFLD from previous observational studies (type 2 diabetes and body mass index), were included in the multivariable Mendelian randomization analysis.ResultsThe results of the univariable Mendelian randomization analysis showed a positive correlation between particulate matter 2.5, gastroesophageal reflux disease, and NAFLD. There was a negative correlation between forced expiratory volume in 1 s, forced vital capacity, and NAFLD. The multivariable Mendelian randomization analysis indicated a direct causal relationship between gastroesophageal reflux disease (OR = 1.537, p = 0.011), type 2 diabetes (OR = 1.261, p < 0.001), and NAFLD.ConclusionThis Mendelian randomization study confirmed the causal relationships between air pollution, lung function, gastroesophageal reflux, and NAFLD. Furthermore, gastroesophageal reflux and type 2 diabetes were identified as independent risk factors for NAFLD, having a direct causal connection with the occurrence of NAFLD.

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“…Although there is a lack of evidence regarding the interrelation between colonic diverticulosis and NAFLD, it has been suggested that these two disorders commonly co-exist and share several traits of MetS [19]. Kempi ński et al reported concomitant colonic diverticulosis as the second most frequent gastrointestinal disease along with NAFLD (after gastroesophageal reflux disease) that was more prevalent in the patients' group than in the controls (23.7% vs. 15.8%; p < 0.005) [20], while Bae et al reported a higher overall prevalence of fatty liver in colonic diverticulosis patients (69.7%) as compared to the results of this study [21]. Additionally, the evaluated characteristics of metabolic dysregulation (fasting glucose, systolic blood pressure, triglycerides, total cholesterol, and CRP) were more prominent in colonic diverticulosis patients in whom hepatic steatosis was detected.…”

Section: Discussionmentioning

confidence: 99%

Colonic Diverticulosis and Non-Alcoholic Fatty Liver Disease: Is There a Connection?

Pantic¹,

Lugonja²,

Rajović

et al. 2021

Medicina

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Background and Objectives: The development and severity of colonic diverticulosis and non-alcoholic fatty liver disease (NAFLD) has been associated with several components of metabolic syndrome (MetS). Therefore, this study aimed to evaluate a possible connection between NAFLD, colonic diverticulosis, and MetS. Materials and Methods: This retrospective study included patients diagnosed with diverticulosis between January 2017 and December 2019. Data regarding the patient demographics, Diverticular Inflammation and Complication Assessment (DICA) score and category, disease localization, hepatic steatosis, blood pressure, comprehensive metabolic panel, need for colonic surgery, and co-morbidities were collected from medical records. Results: A total of 407 patients with a median age of 68 years (range, 34–89 years) were included (male: 53.81%). The majority was diagnosed with left-sided diverticulosis (n = 367, 90.17%) and an uncomplicated disease course (DICA category 1, n = 347, 85.3%). Concomitant hepatic steatosis was detected in 47.42% (n = 193) of patients. The systolic blood pressure, triglycerides, total cholesterol, C-reactive protein (CRP), and fasting glucose were higher in the NAFLD group (p < 0.001, p < 0.001, p < 0.001, p < 0.001, and p < 0.001, respectively). A higher prevalence of hypertension (HTA), type 2 diabetes mellitus (T2DM), and hypothyroidism was noted in the same group of patients (p < 0.001, p < 0.001, and p = 0.008, respectively). High-density lipoprotein cholesterol was lower in patients with more severe forms of diverticulosis (DICA category 2 and 3), while CRP levels were significantly higher (p = 0.006 and p = 0.015, respectively). HTA and NAFLD were more common in patients with more severe forms of colonic diverticulosis (p = 0.016 and p = 0.025, respectively). Using a multivariate logistic regression, the DICA score, CRP, total cholesterol, HTA, and hypothyroidism were identified as discriminating factors for the presence of hepatic steatosis. Conclusion: Components of metabolic dysregulation were prominent in patients diagnosed with colonic diverticulosis and concomitant hepatic steatosis. HTA, T2DM, and hypothyroidism were more frequently observed in this group. Hepatic steatosis was more commonly detected in more severe forms of colonic diverticulosis.

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Clinical outcomes of non-alcoholic fatty liver disease: Polish-case control study

Cited by 9 publications

References 24 publications

Diverticulosis and cardiometabolic risk factors: a systematic literature review

Diverticulosis and cardiometabolic risk factors: a systematic literature review

Causal relationship between air pollution, lung function, gastroesophageal reflux disease, and non-alcoholic fatty liver disease: univariate and multivariate Mendelian randomization study

Colonic Diverticulosis and Non-Alcoholic Fatty Liver Disease: Is There a Connection?

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