Clinical outcomes of fasting in patients with chronic heart failure with preserved ejection fraction: A prospective analysis

Alam, Shafiq; Hussain, Shoukat; Abbas, Jawad; Raza, Muhammad Hassan; Rasool, Waqar Arif; Alsubai, Abdulla K.; Al-Mousawi, Razan; Aldhaheri, Khaled Saeed Obaid; Malik, Jahanzeb; Almas, Talal

doi:10.1016/j.amsu.2022.104373

Cited by 5 publications

(5 citation statements)

References 5 publications

(7 reference statements)

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“…Finally, the left ventricular EF% remained within the same percentage among the patients in question (p-value=0.85). It is consistent with previous studies for both heart failure with reduced and preserved EF published in 2018 and 2022, respectively [ 45 , 46 ]. These findings might be assigned to the effect of Intermittent fasting on increasing galectin-3, a key protein that controls inflammation and protects the heart, according to a primary and secondary analysis of two randomized control trials [ 47 , 48 ].…”

Section: Discussionsupporting

confidence: 93%

Effects of Ramadan Intermittent Fasting on the Severity of β-Thalassemia Major Patients

Ibraheem¹

2023

Cureus

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Background: β-thalassemia major (β-TM) is an inherited autosomal recessive disorder manifested by the hemoglobin β chain synthesis alteration. It is a lifelong illness with a scope of a wide range of complications. Many kinds of literature evaluated the effect of Ramadan intermittent fasting (RIF) on different medical conditions. However, there are no precise guidelines regarding its effect on patients with β-TM.Methods: A retrospective cohort study was conducted on β-TM patients who visited the hereditary blood disorder center at Al Karama Teaching Hospital in Baghdad. Accordingly, six parameters were used to evaluate the effect of RIF on β-TM patients before, during, and after Ramadan. These parameters include hemoglobin level, frequency of transfusion, aspartate aminotransferase (AST) level, alanine aminotransferase (ALT) level, left ventricular ejection fraction % (EF%), and spleen size. All of these details, including the demographic characteristics of age, gender, history of splenectomy, and body mass index (BMI) were retrieved from the patient's medical records after confirming their fasting through one-to-one interviews. This study aimed to fill the gap and investigate the possible effect of RIF on the severity of β-TM.Results: A total of 184 β-TM patients were enrolled in this study. The mean duration of fasting was 25.2±2.18 days. More than half (110) of the patients were females (59.8%). Whereas, the mean age was 24.8±3.5 years. One-third of the patients (65) had a splenectomy (35.3%) and more than two-thirds had normal BMI. The initial parameters used to score the severity of β-TM were evaluated separately. As a result, the hemoglobin level remained steady without any statistical significance during the three months. In addition, the frequency of blood transfusion and the spleen size carried the same result. Although the lowest median and range of liver enzymes were recorded during Ramadan, they were statistically insignificant compared to pre and post-fasting. Moreover, the left ventricular EF% was insignificant regardless of the patient's history of heart disease.Conclusion: This study revealed that RIF does not seem to affect the severity of β-TM if the patients proceed with fasting. However, further studies in more countries with a bigger sample size are recommended to confirm these findings.

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Section: Discussionsupporting

confidence: 93%

Effects of Ramadan Intermittent Fasting on the Severity of β-Thalassemia Major Patients

Ibraheem¹

2023

Cureus

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“…In conclusion, there was no significant difference in STEMI-onset time, but the time from symptom onset to hospital admission was significantly delayed during Ramadan. Finally, Alam et al 25 investigated how RF affects patients with heart failure (HF) with preserved ejection fraction (HFpEF). They enrolled 456 fasting and 482 non-fasting patients in a prospective observational study.…”

Section: Resultsmentioning

confidence: 99%

“…In 2022, seven original research articles addressed various aspects of cardiovascular disease (CVD) [23][24][25] and risk factors [26][27][28][29] associated with RF: four on cardiac events and three on risk factors. Four other articles provided practical guidelines and management recommendations for people with CVD during RF.…”

Section: Cardiovascular Disease and Risk Factorsmentioning

confidence: 99%

Review of the Literature on Ramadan Fasting and Health in 2022

Hafidh

Khan

Shaikh

et al. 2023

Ibnosina Journal of Medicine and Biomedical Sciences

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Objectives The literature on health and disease during Ramadan fasting (RF) is widely spread in many journals making it not readily accessible to those interested in the subject. Here, we provide an overview of the research on the interplay of RF with various aspects of well-being published in 2022. Materials and Methods A narrative, nonsystematic review of the international literature from a single major medical online database, PubMed, in one calendar year (2022) was conducted. The search term “Ramadan fasting” was used to retrieve the appropriate records. The relevant literature with substantial data-based content was presented in a concise thematic account, excluding those concerned with diabetes. Results Themes that emerged from the review included the pathophysiology of metabolic changes during RF, nutritional aspects including body composition and energy metabolism, cardiovascular disease and risk factors, renal function and structure, endocrinology (mainly thyroid), neurological disorders, mental health, pregnancy and fetal life, and infections (including COVID). Some miscellaneous clinical themes were identified, such as patients' and professional perspectives. Conclusions In 2022, the medical interest in RF was again widely spread across specialties. Cardiovascular disease and risk factors attract the most interest in terms of original articles and professional guidelines. We hope with this review to present a concise summary of the scholarly work on the subject in this year.

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“…32 A Pakistani observational study of patients with heart failure with preserved ejection fraction demonstrated improved serological cardiovascular risk profiles, volume status, and decreased rates of atrial fibrillation. 33 In patients with heart failure with reduced ejection fraction, over 90% had improved or neutral NYHA functional classification. Medication nonadherence was the causative factor in those who experienced exacerbations during Ramadan.…”

Section: Cardiac Diseasementioning

confidence: 99%

Patient Care During Ramadan: A Narrative Review

Bhuiyan,

Saadiq,

Mueller

et al. 2024

Health Services Research and Managerial Epidemiology

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Ramadan is the Islamic holy month when Muslims around the world fast from dawn to sunset. This 30-day pattern of intermittent diurnal fasting can have a significant physiologic impact on the body. Importantly, oral intake is forbidden during this time, and many patients do not wish to take medications. From a clinical perspective, this potentially impacts healthcare delivery and chronic disease states. Despite these important changes, awareness of individual patient practices remains limited among healthcare providers in North America, which may worsen health disparities in Muslim patients. A fundamental understanding of the cultural and physiological implications of fasting during Ramadan can improve cultural competence and patient outcomes. In this paper, we review the physiologic changes during fasting, medical exemptions to fasting, and special considerations for the care of Muslim patients with chronic conditions who may fast during Ramadan.

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Clinical outcomes of fasting in patients with chronic heart failure with preserved ejection fraction: A prospective analysis

Cited by 5 publications

References 5 publications

Effects of Ramadan Intermittent Fasting on the Severity of β-Thalassemia Major Patients

Effects of Ramadan Intermittent Fasting on the Severity of β-Thalassemia Major Patients

Review of the Literature on Ramadan Fasting and Health in 2022

Patient Care During Ramadan: A Narrative Review

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