Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

Espiritu, Adrian I.; Bravo, Sybil Lizanne; Sombilla, Hannah Andrea A.; Tantengco, Ourlad Alzeus G.; Sy, Marie Charmaine C.; Sy, Alvin Duke R.; Anlacan, Veeda Michelle M.; Jamora, Roland Dominic G.

doi:10.3390/vaccines11020226

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…In a study, it was reported that since typical pregnancy symptoms may overlap with COVID-19 manifestations like shortness of breath, nasal congestion, fatigue, or nausea and vomiting, physicians should be more discerning and thorough in evaluating the gravida status during a pandemic like COVID. 13 Among the total of our participants, about half of the patients (45%) were nulliparous, 32% were primiparous, and 23% were multiparous. A previously conducted study noted that the most frequent symptoms in pregnant COVID-19positive cases were cough in 65%, fever in 57%, shortness of breath in 47%, sore throat in 22%, anosmia in 16%, and headache in 15%.…”

Section: Discussionmentioning

confidence: 84%

Obstetric perinatal outcomes in COVID-19-positive pregnant women

Begum,

Akther,

Bushra

2024

Int J Reprod Contracept Obstet Gynecol

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Background: In December 2019, a novel coronavirus disease (COVID-19) emerged in Wuhan, China, with an incredible infection rate. The vertical transmission of COVID-19 is uncertain. Pregnant females are considered a high‑risk group for the prevention and control of various communicable diseases. This study aimed to assess the obstetric perinatal outcomes in Covid-19 positive pregnant women. Methods: This was a descriptive cross-sectional study and was conducted in the department of Obstetrics and Gynaecology, Mugda Medical College, Dhaka, Bangladesh from 26 March 2021 to 21 July 2022. A total of 94 pregnant women diagnosed as COVID-19 patients by RT-PCR tests were enrolled in this study as the study subjects purposively. Data were analysed by using MS Office tools. Results: In the study, 23% of participants experienced lower abdominal pain as a pregnancy symptom, with 11%, 4%, and 9% reporting premature rupture of membranes, decreased fetal movement, and antepartum haemorrhage, respectively. Among the participants, 45% had vaginal deliveries, 15% had assisted vaginal deliveries, and 40% underwent lower uterine caesarean sections. Notably, 11% required ICU admission. The study recorded maternal and neonatal mortality rates of 2% and 4%, respectively, and 9% of babies needed incubation. The average APGAR score (5 minutes) was 6.8±0.2, and the mean birth weight was 2.5±0.3. Conclusions: Lower abdominal pain and premature rupture of membranes (PROM) may be considered some major pregnancy symptoms for COVID-19-positive pregnant women. For such cases, proper facilities for LUCS, ICU and incubation are needed.

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Section: Discussionmentioning

confidence: 84%

Obstetric perinatal outcomes in COVID-19-positive pregnant women

Begum,

Akther,

Bushra

2024

Int J Reprod Contracept Obstet Gynecol

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“…2 cancer, h ighe r body mass ind ex, strok e, and dementia all conferred poorer clinical outcomes (increased risk of mortality, respiratory failure, and need for ICU admission) among Filipino COVID-19 patients [4][5][6][7][8][9]. On the other hand, outcome was the same for pregnant and non-pregnant women with COVID-19 [10].…”

Section: Introductionmentioning

confidence: 96%

Clinical Outcomes of COVID-19 Infection among Patients with Chronic Obstructive Pulmonary Disease: Findings from the Philippine CORONA Study

Jamora,

Albay,

Ditching

et al. 2023

Preprint

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Background: The global pandemic of coronavirus disease 2019 (COVID-19) resulted to many deaths from fulminant respiratory failure. Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. There has been great concern regarding the impact of COPD on COVID-19 illness. Methods: Data from the Philippine CORONA Study were analyzed to determine the association of COPD and COVID-19 in terms of mortality, disease severity, respiratory failure, mechanical ventilation, and lengths of stay in the intensive care unit (ICU) and hospital. The influence of smoking on COVID-19 disease severity and mortality were also reviewed. Results: A total of 10,881 patients were included in the study and 156 (1.4%) patients had been diagnosed with COPD. Majority of COVID-19 patients with COPD had other existing comorbidities: hypertension, diabetes mellitus, chronic cardiac disease, and chronic kidney disease. COPD patients more commonly present with severe or critical COVID-19. COPD patients with COVID-19 were at higher risk to experience in-hospital mortality, respiratory failure, and to be admitted in the ICU. Smokers were more likely to present with higher COVID-19 severity and experience in-hospital mortality. Conclusion: Our study supports that the growing evidence that COPD among COVID-19 patients is a risk for higher mortality, more severe form of COVID-19, higher ICU admission, and higher respiratory failure needing ventilatory support. Smoking increases risk for developing severe COVID-19 and mortality.

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“…[ 10 18 19 20 ] The entire spectrum of maternal and neonatal consequences of COVID-19 infection in pregnancy and after delivery is still unknown and the vertical transmission is doubtful. [ 21 22 23 ]…”

Section: Introductionmentioning

confidence: 99%

“…Based on certain evidence, the noxious outcomes of COVID-19 in mothers and neonates are higher in low- and middle-income countries. [ 24 25 ] Therefore, due to the harmful consequences of COVID-19 infection for mother and her neonate,[ 21 ] especially in low-income countries,[ 24 25 ] this review was conducted to evaluate the common maternal and neonatal adverse consequences of mothers with COVID-19 during pregnancy and after delivery.…”

Section: Introductionmentioning

confidence: 99%

Severe acute respiratory syndrome coronavirus 2 infection symptoms in pregnancy and maternal and neonatal complications due to COVID-19: A systematic review

et al. 2023

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A BSTRACT Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnant women is associated with severe maternal and neonatal complications including maternal and newborn death. Aims: This review aimed to assess the SARS-CoV-2 infection symptoms during pregnancy as well as maternal and neonatal complications in Iran. Settings and Design: A developing and low-income country and a systematic review. Materials and Methods: International scientific databases including PubMed, Web of Science, Scopus and Google Scholar were searched in a systematic review manner. Two independent researchers were checked and identified articles from September 2019 to September 2022 based on eligibility criteria and quality appraisal. The results of review were reported in two sections including maternal and neonatal outcomes. Statistical Analysis Used: Descriptive statistics was used for statistical analysis. Results: Seventeen studies including 870 pregnant mothers with COVID-19 met the eligibility criteria and were reviewed. The main maternal consequences of COVID-19 were intensive care unit (ICU) admission, pre-term delivery, maternal death, pre-mature rupture of membranes, pre-eclampsia, intrauterine growth retardation and stillbirth. Neonatal ICU admission, newborn death, neonatal sepsis, low birth weight and respiratory distress syndrome, tachypnoea, asphyxia and pneumothorax were the most common outcomes of COVID-19 infection in offspring of pregnant subjects. Conclusion: Pregnant mothers with COVID-19 infection are at higher risk of being admitted to the ICU and mechanical ventilation and consequently maternal and neonatal death. Comparing the maternal and foetal consequences in different ethnicities, regions and countries may be related to the socioeconomic status of people and should be considered with respect to different determines. Moreover, the maternal and neonatal complications due to COVID-19 infection in Iran and other developing countries seem to be higher than other countries.

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Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

Cited by 5 publications

References 23 publications

Obstetric perinatal outcomes in COVID-19-positive pregnant women

Obstetric perinatal outcomes in COVID-19-positive pregnant women

Clinical Outcomes of COVID-19 Infection among Patients with Chronic Obstructive Pulmonary Disease: Findings from the Philippine CORONA Study

Severe acute respiratory syndrome coronavirus 2 infection symptoms in pregnancy and maternal and neonatal complications due to COVID-19: A systematic review

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