Clinical Outcomes of Cerebral Infarctions in Neonates

Yi, Yoon Young; Lee, Jun Sook; Jang, So Ick; Song, Jaewon; Yang, Seung; Kim, Sung Koo; Lim, Kyoung Ja; Hwang, Il Tae

doi:10.1016/j.pediatrneurol.2011.09.009

Cited by 5 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patients were followed up for a mean duration of 15.4 months, and eight (28%) patients were diagnosed with cerebral palsy during this period. A previous report stated that the incidence of cerebral palsy was 26-68% (9), and studies from Korea have reported that hemiplegia or hemiparesis occurred in 31-57% of patients (12,13). In our study, delayed development without any motor deficit was noted in 6 (21%) patients.…”

Section: Discussionsupporting

confidence: 58%

“…An international study of AIS patients reported that 49% had neurological deficits, including hemiparesis, with an odds ratio (OR) of 1.29, tone abnormalities (OR 4.56), focal deficit (OR 8.67) and feeding difficulties (OR 2.31) on discharge from the hospital (3). Korean studies on AIS have been performed previously, but these only included a small number of patients and the clinical conditions were diverse (12)(13)(14)(15). These studies reported that 38-70% of patients showed normal development, while 31-57% showed hemiplegia and hemiparesis (12)(13)(14)(15).…”

Section: Key Notesmentioning

confidence: 99%

“…Korean studies on AIS have been performed previously, but these only included a small number of patients and the clinical conditions were diverse (12)(13)(14)(15). These studies reported that 38-70% of patients showed normal development, while 31-57% showed hemiplegia and hemiparesis (12)(13)(14)(15). The clinical manifestations and outcomes of AIS patients are unclear.…”

Section: Key Notesmentioning

confidence: 99%

See 2 more Smart Citations

Abnormal neurodevelopmental outcomes are very likely in cases of bilateral neonatal arterial ischaemic stroke

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 58%

Section: Key Notesmentioning

confidence: 99%

Section: Key Notesmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal neurodevelopmental outcomes are very likely in cases of bilateral neonatal arterial ischaemic stroke

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The internal capsule as well as the deep gray matter involving the basal ganglia more often is associated with neuromotor disability. 52,53 Cortical involvement in the MCA distribution with involvement of the basal ganglia and the internal capsule is associated with hemiplegia, while those with basal ganglia and internal capsule without cortical involvement also may have motor coordination difficulties. 54 Magnetic resonance imaging has played a pivotal role in detecting stroke in term neonates.…”

Section: Clinical Presentation Of Perinatal Strokementioning

confidence: 99%

Mechanisms of Perinatal Arterial Ischemic Stroke

Fernández-López

Natarajan

Ashwal

et al. 2014

J Cereb Blood Flow Metab

108

View full text Add to dashboard Cite

The incidence of perinatal stroke is high, similar to that in the elderly, and produces a significant morbidity and severe long-term neurologic and cognitive deficits, including cerebral palsy, epilepsy, neuropsychological impairments, and behavioral disorders. Emerging clinical data and data from experimental models of cerebral ischemia in neonatal rodents have shown that the pathophysiology of perinatal brain damage is multifactorial. These studies have revealed that, far from just being a smaller version of the adult brain, the neonatal brain is unique with a very particular and age-dependent responsiveness to hypoxia-ischemia and focal arterial stroke. In this review, we discuss fundamental clinical aspects of perinatal stroke as well as some of the most recent and relevant findings regarding the susceptibility of specific brain cell populations to injury, the dynamics and the mechanisms of neuronal cell death in injured neonates, the responses of neonatal blood-brain barrier to stroke in relation to systemic and local inflammation, and the long-term effects of stroke on angiogenesis and neurogenesis. Finally, we address translational strategies currently being considered for neonatal stroke as well as treatments that might effectively enhance repair later after injury.

show abstract

“…The underlying cause in many patients is unclear, but signs of dehydration and sepsis should be searched for in examination of the records and the child. Thrombosis of the venous sinuses has a mortality approaching 80% (12).…”

Section: Discussionmentioning

confidence: 99%

Neuropathology Associated with Hypoxic-Ischemic Injury in Sudden Unexpected Natural Death in Neonates and Infants

Welsh

2015

Academic Forensic Pathology

View full text Add to dashboard Cite

Unexpected death in neonates and infants has no explanation in a larger percentage of cases than is true for adults. Sudden death in neonates/infants secondary to central nervous system (CNS) causes is relatively uncommon. Birth injury is typically but not always recognized. Even with a history of CNS injury, the death may still be unexpected. CNS pathology is fairly common at postmortem examination, but is often not causal. One of the most common critical neuropathologies is hypoxic-ischemic and may be hemorrhagic. In both the acute and chronic phases, the differentiation from nonaccidental trauma needs to be evaluated. Evaluation is best achieved in a well-fixed brain. Some pathology cannot be seen macroscopically and requires microscopic sections.

show abstract

Clinical Outcomes of Cerebral Infarctions in Neonates

Cited by 5 publications

References 21 publications

Abnormal neurodevelopmental outcomes are very likely in cases of bilateral neonatal arterial ischaemic stroke

Abnormal neurodevelopmental outcomes are very likely in cases of bilateral neonatal arterial ischaemic stroke

Mechanisms of Perinatal Arterial Ischemic Stroke

Neuropathology Associated with Hypoxic-Ischemic Injury in Sudden Unexpected Natural Death in Neonates and Infants

Contact Info

Product

Resources

About