Clinical Outcomes of Biologic Mesh

Harris, Hobart W.

doi:10.1016/j.suc.2013.06.001

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…However, occasionally these materials fail to induce or only partially induce a constructive tissue remodeling response with some patients showing robust functional improvement and others showing little improvement along with a marked inflammatory response 55-60 . One potential source of these divergent results may lie in the pre- and post-operative regimen prescribed for these patients (e.g., NSAID administration, physical therapy, etc.).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury

et al. 2016

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Extracellular matrix (ECM) has been used as a biologic scaffold material to both reinforce the surgical repair of soft tissue and serve as an inductive template to promote a constructive tissue remodeling response. Success of such an approach is dependent on macrophage-mediated degradation and remodeling of the biologic scaffold. Macrophage phenotype during these processes is a predictive factor of the eventual remodeling outcome. ECM scaffolds have been shown to promote an anti-inflammatory or M2-like macrophage phenotype in vitro that includes secretion of downstream products of cycolooxygenases 1 and 2 (COX1/2). The present study investigated the effect of a common COX1/2 inhibitor (Aspirin) on macrophage phenotype and tissue remodeling in a rodent model of ECM scaffold treated skeletal muscle injury. Inhibition of COX1/2 reduced the constructive remodeling response by hindering myogenesis and collagen deposition in the defect area. The inhibited response was correlated with a reduction in M2-like macrophages in the defect area. The effects of Aspirin on macrophage phenotype were corroborated using an established in vitro macrophage model which showed a reduction in both ECM induced prostaglandin secretion and expression of a marker of M2-like macrophages (CD206). These results raise questions regarding the common peri-surgical administration of COX1/2 inhibitors when biologic scaffold materials are used to facilitate muscle repair/regeneration.

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Section: Discussionmentioning

confidence: 99%

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury

et al. 2016

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“…Thus, it should not be forgotten that this phenomenon is driving a multimillion dollar market. Several authors caution against overuse and call for a more critical evaluation [42][43][44][45]. Biological meshes have been available for 15 years.…”

Section: Biological Implantsmentioning

confidence: 99%

“…There is on-going criticism that in spite of long-term clinical use the efficacy (wound complications, long-term performance and incidence of hernia recurrence) has been insufficiently investigated. Because of the high costs (10-20fold more expensive) and missing level I evidence, there is a warning against uncritical use [42][43][44][45].…”

Section: Biological Implantsmentioning

confidence: 99%

Complex Incisional Hernias

Scheuerlein¹,

Settmacher²,

Lenschow³

et al. 2016

Arch Clin Gastroenterol

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“…Lightweight PP mesh could cause viscera adhesion and elicit an obvious inflammatory response associated with fibroblast gathering. [6,7] Dense fibrous tissue forms within and around the mesh material, which can lead to complications such as bowel obstruction, perforation, infertility, and chronic discomfort. [8,9] Since the proportion of surgical procedures performed via laparoscopy increased during the past ten years, efforts of developing intraperitoneal repair mesh on the basis of polypropylene material had been constantly undertaken to satisfy clinical requirement.…”

Section: Doi: 101002/mabi201800067mentioning

confidence: 99%

“…However, intraperitoneal repair of lightweight PP mesh is prohibited due to its hydrophobicity and consequently severe adhesive property. Lightweight PP mesh could cause viscera adhesion and elicit an obvious inflammatory response associated with fibroblast gathering . Dense fibrous tissue forms within and around the mesh material, which can lead to complications such as bowel obstruction, perforation, infertility, and chronic discomfort .…”

Section: Introductionmentioning

confidence: 99%

Lightweight, Highly Permeable, Biocompatible, and Antiadhesive Composite Meshes for Intraperitoneal Repairs

Lin

Huang

et al. 2018

Macromolecular Bioscience

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Ventral hernia is a public health issue and millions of meshes are used to repair abdominal wall defects every year. Polypropylene-based composite meshes represent an important class of materials for intraperitoneal repair, but the meshes generally give rise to infection, seroma, migration, and adhesion, leading to severe consequence or even reoperation. Here, a facile and versatile one-way fabrication of lightweight, highly permeable, and biocompatible composite meshes with superior antiadhesion properties is proposed by modifying polypropylene meshes with well-defined polydopamine nanocoating. The resulting composite meshes are found to significantly enhance the biocompatibility and antiadhesion effect in rat model. The scalable production and excellent biomedical properties of composite meshes make them a promising candidate for future-generation ventral hernia repair materials.

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Clinical Outcomes of Biologic Mesh

Cited by 16 publications

References 30 publications

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury

Complex Incisional Hernias

Lightweight, Highly Permeable, Biocompatible, and Antiadhesive Composite Meshes for Intraperitoneal Repairs

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