Clinical Outcomes of Acute Pancreatitis in Patients with Cirrhosis According to Liver Disease Severity Scores

Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepatocellular carcinoma by reactive oxygen species generation and microbiota rebalancing

“…5G). 40–42 These data revealed that the treatment with P-ELNs (L and H) decreased the levels of these biomarkers to a degree comparable to that of healthy controls, in contrast to that in the PBS group. In particular, P-ELN (H) treatment significantly reduced TBA, BUN, ALT, and AST levels, which were 2.3-, 1.7-, 1.9-, and 2.1-fold lower than those of the PBS control group.…”

Impacts of body composition parameters and liver cirrhosis on the severity of alcoholic acute pancreatitis

“…In our study, liver cirrhosis was found to best predict AAP severity (adjusted OR, 4.192; 95% CI, 1.620–10.848) and to do so independently of fatty liver. Recently, two retrospective cohort studies on the clinical outcomes of AP in patients with cirrhosis were published [ 39 , 40 ]. A single-center study concluded that morbidity and mortality among AP patients with or without cirrhosis were similar [ 39 ], whereas a national cohort study conducted in the USA reported AP patients with cirrhosis had higher inpatient mortality (OR 3.4, P < 0.001) [ 40 ].…”

“…Recently, two retrospective cohort studies on the clinical outcomes of AP in patients with cirrhosis were published [ 39 , 40 ]. A single-center study concluded that morbidity and mortality among AP patients with or without cirrhosis were similar [ 39 ], whereas a national cohort study conducted in the USA reported AP patients with cirrhosis had higher inpatient mortality (OR 3.4, P < 0.001) [ 40 ]. However, AP severity was not assessed in the US national cohort study, and only 19 alcoholic cirrhosis patients were included in the single-center study [ 39 ].…”

“…A single-center study concluded that morbidity and mortality among AP patients with or without cirrhosis were similar [39], whereas a national cohort study conducted in the USA reported AP patients with cirrhosis had higher inpatient mortality (OR 3.4, P < 0.001) [40]. However, AP severity was not assessed in the US national cohort study, and only 19 alcoholic cirrhosis patients were included in the single-center study [39]. Furthermore, AP patients with all etiologies were included in both studies.…”

High risk of complications and mortality in cirrhotic patients with acute pancreatitis

“…The publication of Vogel et al [7] is timely and interesting since previous available literature is scarce. Another recent smaller retrospective single-center study [8] compared 40 cirrhotic patients with acute pancreatitis (4.9% of all patients with acute pancreatitis in their database) with 80 non-cirrhotic acute pancreatitis patients (selected by 1:2 propensity score matching). The authors conclude from their data, that cirrhotic patients had similar morbidity and mortality.…”