Clinical Outcomes of Acute Myocardial Infarction Patients With a History of Malignant Tumor

Abstract

Background: Little is known about the clinical outcomes of acute myocardial infarction (AMI) in patients with a history of malignant tumor (MT). Patients and Methods: We retrospectively studied 1,295 consecutive patients with AMI who underwent primary percutaneous coronary intervention within 24 hours of onset. The patients were divided into two groups: those with a history of MT (MT group, n=50) and those without n=1,245). Results: The MT group was older, and had lower hemoglobin, total protein, and albumin levels. All-cause mortality and re-admission rates due to acute decompensated heart failure (ADHF) were significantly higher in the MT group. Multivariate analysis showed that a history of MT was an independent predictor for all-cause mortality and re-admission due to ADHF. Conclusion: The clinical outcomes of patients with AMI with a history of MT are poor, and a history of MT is an independent predictor for all-cause mortality and re-admission due to ADHF. These patients may need careful risk management for heart failure to avoid re-admissions due to ADHF.Acute myocardial infarction (AMI) is a life-threatening disease that is common in developed countries. Although prognosis has improved dramatically since the development of primary percutaneous coronary intervention (PCI) in the early 1990s, ST elevation myocardial infarction (STEMI) still has a poor prognosis, with an in-hospital mortality rate of 7.1% in Japan (1). Another fatal disease is the development of a malignant tumor (MT) (2). Previous studies have shown a close relation between MTs and cardiovascular disease. MTs themselves cause venous or arterial thrombosis due to abnormal coagulation, platelet activation, and endothelial dysfunction (3). Regarding the treatment for MT, modern treatment strategies have improved relapse-free survival but they often induce the development of cardiovascular disease. Chemotherapy, such as with classical therapeutic drugs and molecular targeted drugs, and radiotherapy sometimes cause heart failure, thrombosis, ischemic heart disease, valvular disease, and hypertension (4, 5). Previous studies have reported that MTs adversely affect the development of cardiovascular disease but only few reports have investigated the clinical outcomes of AMI patients with a history of MT. In the present study, we investigated the clinical characteristics and outcomes of patients with AMI with a history of MT. Patients and MethodsStudy population. We retrospectively studied 1,295 consecutive patients with AMI who were admitted to our hospital and underwent primary PCI within 24 hours from the onset of symptoms between January 2007 and December 2016. The patients who were admitted to our hospital after 24 hours from onset or those who did not undergo primary PCI were excluded. The patients were divided into two groups as follows: those who had a history of MT and those without. The MT group consisted of patients who had a past history of MT and those who were diagnosed during hospitalization for AMI treatment. Moreover, we included...

Characteristics of malignant tumors of digestive system and autoimmune diseases

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