Clinical outcomes of 3-D conformal hypofractionated single high dose radiotherapy for one or two lung tumors using a stereotactic body frame

Nagata, Yukihiro; Negoro, Yuki; Aoki, Tomokazu; Mizowaki, Takashi; Takayama, Kohei; Yano, Shinichi; Shibamoto, Y.; Kokubo, Mitsunori; Hiraoka, Masakatsu

doi:10.1016/s0360-3016(01)02473-7

Cited by 4 publications

(1 citation statement)

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“…The challenges to performing "body radiosurgery" are being met through the development of a stereotactic body frame and improvements in respiratory gating systems. Several series, originating mainly from Japan, have been reported [40][41][42][43], and a prospective trial is ongoing at Indiana University. The majority of patients have been treated in multiple fractions, although single-fraction SRS has been reported [43].…”

Section: Emerging Therapiesmentioning

confidence: 99%

Early stage medically inoperable non-small cell lung cancer

Scalzetti¹,

Dexter²

2003

Curr. Treat. Options in Oncol.

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A nihilistic approach to the treatment of patients with medically inoperable, early stage non-small cell lung cancer (NSCLC) is not warranted. Despite the frequency of comorbid medical illness in patients with medically inoperable NSCLC, lung cancer progression is the major cause of morbidity and death. Although expectations for cure are reduced compared to good-risk patients (eg, adequate pulmonary reserve), modest long-term survival rates of patients have been reported, after definitive therapy. A comparison of radiotherapy and limited resection is difficult because of the lack of randomized data and the selection bias inherent in retrospective reports. For example, patients treated with surgery have peripheral lesions, undergoing rigorous staging compared to patients treated with radiotherapy. In a multidisciplinary thoracic program, patients are counseled on the options of sublobar resection and conformal radiotherapy. The efficacy of adjuvant radiotherapy, after limited resection, in reducing local recurrence in patients with medically inoperable NSCLC is unclear. However, adjuvant radiotherapy may be considered if a postoperative target volume can be defined, particularly if resection margins are narrow. Considering the benefit of chemoradiotherapy for patients with locally advanced disease, combination therapy is administered to patients with good performance status and large (eg, > 4 cm) primary lesions, although combined therapy may increase the potential for pulmonary toxicity in patients with baseline pulmonary dysfunction. Prospective data are becoming available to define the value of treatment alternatives for patients with medically inoperable NSCLC. The Cancer and Leukemia Group B completed a phase II study of thoracoscopic wedge resection and postoperative radiotherapy, whereas a phase I trial of dose-intensive accelerated conformal radiotherapy is ongoing. Trials involving systemic therapy for patients with medically inoperable NSCLC should be developed.

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Section: Emerging Therapiesmentioning

confidence: 99%

Early stage medically inoperable non-small cell lung cancer

Scalzetti¹,

Dexter²

2003

Curr. Treat. Options in Oncol.

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New radiotherapy technologies

Rosenzweig

Amols

Ling

2003

Seminars in Surgical Oncology

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Conventional radiation therapy has had limited success in curing inoperable lung cancer due to poor local control. There is evidence to suggest that higher doses of radiation will improve local control. In order to safely deliver higher doses of thoracic radiation, advanced treatment techniques are required. Different biologic indices have been utilized to determine whether dose escalation can be safely accomplished, and the results have been reported from many institutions. Tumor motion control aids in treatment since it allows radiation oncologists to more accurately target tumors and therefore to spare more normal tissue from the radiation field. The imaging information from 18-FDG-PET scans also improves target delineation. Advanced treatment delivery techniques, such as three-dimensional conformal radiation therapy, intensity modulated radiation therapy, and stereotactic radiosurgery are also being used to safely escalate the radiation dose. This article explores the current literature on these issues and other advanced radiation therapy techniques.

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Hypofractionated irradiation for non-small cell lung cancer

Abratt

Hunter

2002

Lung Cancer

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Clinical outcomes of 3-D conformal hypofractionated single high dose radiotherapy for one or two lung tumors using a stereotactic body frame

Cited by 4 publications

References 0 publications

Early stage medically inoperable non-small cell lung cancer

Early stage medically inoperable non-small cell lung cancer

New radiotherapy technologies

Hypofractionated irradiation for non-small cell lung cancer

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