Clinical outcomes in pancreatic adenocarcinoma (PAC) in breast cancer (BC) survivors.

Lowery, Maeve A.; Stadler, ZK; Miller, Elaine L.; D’Adamo, David R.; Salo‐Mullen, Erin; Allen, Peter J.; Kurtz, Robert C.; Kelsen, David P.; O’Reilly, Eileen M.

doi:10.1200/jco.2010.28.15_suppl.4152

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“…Over 6,000 patients were evaluated at MSKCC with a diagnosis of PAC in 2000 -2010; the identification of 15 BRCA1 or BRCA2 mutation carriers and PAC in 2003-2010 is likely to be a substantial underestimation of the true frequency of mutation carriers in this population because the vast majority of patients do not undergo genetic testing. In a prior study at our institution of 38 breast cancer survivors who subsequently developed PAC, just two of the 38 women in that group had undergone BRCA1 or BRCA2 testing [9]. In contrast to breast and ovarian cancers, for which referral for genetic counseling and testing is routine, the majority of patients with PAC and a personal or family history suggestive of BRCA mutation do not undergo genetic testing.…”

Section: Discussionmentioning

confidence: 99%

“…In a prior study at our institution of 38 breast cancer survivors who subsequently developed PAC, just two of the 38 women in that group had undergone BRCA1 or BRCA2 testing [9]. In contrast to breast and ovarian cancers, for which referral for genetic counseling and testing is routine, the majority of patients with PAC and a personal or family history suggestive of BRCA mutation do not undergo genetic testing.…”

Section: Discussionmentioning

confidence: 99%

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An Emerging Entity: Pancreatic Adenocarcinoma Associated with a Known BRCA Mutation: Clinical Descriptors, Treatment Implications, and Future Directions

et al. 2011

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Learning Objectives After completing this course, the reader will be able to: Describe the genetic syndromes associated with pancreas adenocarcinoma. Explain the potential role of platinum‐based therapy and PARP inhibitors in BRCA‐mutated pancreas adenocarcinoma. This article is available for continuing medical education credit at http://CME.TheOncologist.com Background. BRCA1 and BRCA2 germline mutations are associated with an elevated risk for pancreas adenocarcinoma (PAC). Other BRCA‐associated cancers have been shown to have greater sensitivity to platinum and poly(ADP‐ribose) polymerase (PARP) inhibitors with better clinical outcomes than in sporadic cases; however, outcomes in BRCA‐associated PAC have not been reported. Methods. Patients with a known BRCA1 or BRCA2 mutation and a diagnosis of PAC were identified from the Gastrointestinal Oncology Service, Familial Pancreas Cancer Registry, and Clinical Genetics Service at Memorial Sloan‐Kettering Cancer Center. Results. Fifteen patients, five male, with a BRCA1 (n = 4) or BRCA2 (n = 11) mutation and PAC and one patient with a BRCA1 mutation and acinar cell carcinoma of the pancreas were identified. Seven female patients (70%) had a prior history of breast cancer. Four patients received a PARP inhibitor alone or in combination with chemotherapy; three demonstrated an initial radiographic partial response by Response Evaluation Criteria in Solid Tumors whereas one patient had stable disease for 6 months. Six patients received platinum‐based chemotherapy first line for metastatic disease; five of those patients had a radiographic partial response. Conclusion. BRCA mutation–associated PAC represents an underidentified, but clinically important, subgroup of patients. This is of particular relevance given the ongoing development of therapeutic agents targeting DNA repair, which may potentially offer a significant benefit to a genetically selected population. We anticipate that further study and understanding of the clinical and biologic features of BRCA‐mutant PAC will aid in the identification of tissue biomarkers indicating defective tumor DNA repair pathways in sporadic PAC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%