Clinical outcomes in cystic fibrosis patients with Trichosporon respiratory infection

Esther, Charles R.; Plongla, Rongpong; Kerr, A. G.; Lin, Feng‐Chang; Gilligan, Peter H.

doi:10.1016/j.jcf.2016.02.006

Cited by 12 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the contribution of MRSA to CF lung disease has been well defined, the potential pathogenicity of Trichosporon spp. was recently defined [42]. In agreement with Patient 1, Patient 2 showed a FEV 1 decline in association with MRSA respiratory infection.…”

Section: Discussionsupporting

confidence: 55%

Impact of clonally-related Burkholderia contaminans strains in two patients attending an Italian cystic fibrosis centre: a case report

et al. 2019

View full text Add to dashboard Cite

Background Burkholderia contaminans is one of the 20 closely related bacterial of the Burkholderia cepacia complex, a group of bacteria that are ubiquitous in the environment and capable of infecting people with cystic fibrosis (CF). This species is an emerging pathogen and it has been widely isolated from CF patients in Argentina, Spain, Portugal, Australia, Canada, USA with a low prevalence in Ireland, France, Russia, Switzerland, Czech Republic, and Italy. This is the first report of B. contaminans affecting two Italian CF patients attending the same CF Centre. We correlate B. contaminans colonisation with lung function decline and co-infection with other clinically relevant CF pathogens. Case presentation B. contaminans was identified by Multi Locus Sequence Typing in routine sputum analysis of two Caucasian CF women homozygous for Phe508del CFTR mutation. Sequence Type 102 was detected in both strains. It is known that B. contaminans ST102 was isolated both from CF and non-CF patients, with an intercontinental spread across the world. Random Amplified Polymorphic DNA analysis revealed the genetic relatedness between the two strains. We examined their susceptibility to antimicrobial agents, comparing the latter with that recorded for other B. contaminans isolated from different countries. We also described key virulence factors possibly linked with a clinical outcome. Specifically, we attempted to correlate colonization with the incidence of acute exacerbation of symptoms and lung function decline. Conclusions This case presentation suggests that acquisition of B. contaminans ST102 is not directly associated with a lung function decline. We retain that the presence of other CF pathogens (i.e. MRSA and Trichosporon ) along with B. contaminans ST102 might have contributed to the worsening of clinical conditions in our CF patients. The circumstances leading to the establishment of B. contaminans ST102 infections are still unknown. We highlight the importance to proper detect and typing bacteria implicated in CF infection by using molecular techniques.

show abstract

Section: Discussionsupporting

confidence: 55%

Impact of clonally-related Burkholderia contaminans strains in two patients attending an Italian cystic fibrosis centre: a case report

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The prevalences of Trichosporon and Exophiala are not well described in the CFF registry. Epidemiologic data have demonstrated the prevalence of Trichosporon to be an estimated 2.1% in an American cohort (4,11). The prevalence of Exophiala in the United States has not been described.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of Aspergillus species, the most common filamentous fungi in the CF airway, has increased from 6% to 12% over the past 2 decades (2,3). In addition, Scedosporium, Trichosporon, and Exophiala species have been increasingly detected in CF sputa (4)(5)(6)(7)(8)(9)(10)(11). Furthermore, there is increasing evidence that the chronic presence of Aspergillus, Scedosporium, Trichosporon, or Exophiala species in CF individuals is associated with pulmonary morbidity, including respiratory symptoms and pulmonary exacerbations, and even death in the post-lung transplant population (5-9, 11, 12).…”

mentioning

confidence: 99%

Use of Selective Fungal Culture Media Increases Rates of Detection of Fungi in the Respiratory Tract of Cystic Fibrosis Patients

Hong

Miller²,

Allgood³

et al. 2017

J Clin Microbiol

View full text Add to dashboard Cite

The prevalence of fungi in the respiratory tracts of cystic fibrosis (CF) patients has risen. However, fungal surveillance is not routinely performed in most clinical centers in the United States, which may lead to an underestimation of the true prevalence of the problem. We conducted a prospective study comparing the rates of detection for clinically important fungi (CIF), defined as ,, and species and, in CF sputa using standard bacterial and selective fungal culture media, including Sabouraud dextrose agar with gentamicin (SDA), inhibitory mold agar (IMA), and brain heart infusion (BHI) agar with chloramphenicol and gentamicin. We described the prevalence of these fungi in an adult CF population. A total of 487 CF respiratory samples were collected from 211 unique participants. CIF were detected in 184 (37.8%) samples. Only 26.1% of CIF-positive samples were detected in bacterial culture medium, whereas greater rates of detection for fungi were found in IMA (65.8%; < 0.001), in SDA (at 30°C, 64.7%; = 0.005), and in BHI agar (63.0%; = 0.001). The prevalences of and species were 40.8% and 5.2%, respectively, which are greater than the nationally reported prevalence numbers of 20.4% and 1.9%. Selective fungal culture media and longer incubation periods yielded higher rates of detection for CIF in CF sputum samples compared with that detected in bacterial culture medium, resulting in an underdetection of fungi by bacterial culture alone. The prevalence of fungi in CF may be better estimated by using selective fungal culture media, and this may translate to important clinical decisions.

show abstract

“…74 Although their clinical significance remains uncertain, noteworthy is that Rasamsonia argillacea, Trichosporon spp., and a few others have been possibly associated with long-term declines in lung function, and with invasive diseases after lung transplantation. 75-77…”

Section: Other Fungimentioning

confidence: 99%

Respiratory Fungal Diseases in Adult Patients With Cystic Fibrosis

Delfino

Puente

Briano

et al. 2019

Clin Med Insights Circ Respir Pulm Med

View full text Add to dashboard Cite

Clinical manifestations of respiratory fungal diseases in adult cystic fibrosis (CF) patients are very heterogeneous, ranging from asymptomatic colonization to chronic infections, allergic disorders, or invasive diseases in immunosuppressed CF patients after lung transplantation. In this narrative review, mainly addressed to clinicians without expertise in CF who may nonetheless encounter adult CF patients presenting with acute and chronic respiratory syndromes, we briefly summarize the most representative clinical aspects of respiratory fungal diseases in adult CF patients.

show abstract

Clinical outcomes in cystic fibrosis patients with Trichosporon respiratory infection

Abstract: Trichosporon can be recovered from a small but clinically meaningful fraction of CF patients. The presence of Trichosporon, but not Chryseobacterium, is associated with greater declines in lung function.

Cited by 12 publications

References 13 publications

Impact of clonally-related Burkholderia contaminans strains in two patients attending an Italian cystic fibrosis centre: a case report

Impact of clonally-related Burkholderia contaminans strains in two patients attending an Italian cystic fibrosis centre: a case report

Use of Selective Fungal Culture Media Increases Rates of Detection of Fungi in the Respiratory Tract of Cystic Fibrosis Patients

Respiratory Fungal Diseases in Adult Patients With Cystic Fibrosis

Contact Info

Product

Resources

About