Clinical outcomes from maximum-safe resection of primary and metastatic brain tumors using awake craniotomy

Groshev, Anastasia; Padalia, Devang; Patel, Sephalie Y.; Garcia-Getting, Rosemarie; Sahebjam, Solmaz; Forsyth, Peter; Vrionis, Frank D.; Etame, Arnold B.

doi:10.1016/j.clineuro.2017.03.017

“…24 In our initial experience, 80 patients had total or near total resection, which represents a good resection range, comparable to or better than the 91% of total or near total resection reported thus far. 25 The rate of new neurological damage has been reported to be 18-23% has been reported. 26,27,28 In our study, 91% of patients had either improved or no change in their neurological status.…”

Section: Discussionmentioning

confidence: 99%

The effect of using awake craniotomy combined with multimodal techniques intraoperative on survival of patients with glioblastoma: a single-center experience

zhou

¹

,

Li

²

,

Lu³

et al. 2020

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Background :We analysed outcomes of cerebral glioblastoma patients undergoing awake craniotomies combined with multimodal techniques for tumour resection, with regards to the extent of resection, functional preservation, and prognosis. Methods : A retrospective analysis was conducted on adult glioblastoma patients who underwent an awake craniotomy from September 2010 to August 2018 under anaesthesia combined with multimodal techniques. Results: In total, 81 glioblastoma patient charts were analysed. The most common lesion sites were the frontal lobe (n=36), temporal lobe (n=17), and parietal lobe (n=6). The main symptoms were headache (n=51), dyskinesia (n=11), speech disorder (n=9), and epilepsy (n=10). The extent of resection was gross total for 91.36% patients, subtotal for 7.41%, and partial for 1.23%. No deaths occurred 30 days post-operation. Intracranial haemorrhage occurred in 2 patients, seizures in 5 patients, and intracranial infections in 3 patients. There was no significant difference between preoperative and postoperative Karnofsky Performance Status scores (P>0.05). There were no significant changes in postoperative neurological function in 50 patients. Symptoms improved in 24 patients. Three patients exhibited motor dysfunction, 2 exhibited speech deficits, and 2 exhibited sensory deficits. The average duration of hospitalization was 6.89±2.66 days. The shortest survival time was 4 months, the longest survival time was 26 months, and the median survival time was 12 months. Conclusions: Awake craniotomy using multimodal techniques such as neuronavigation, intraoperative ultrasound, electrophysiology, and tumour fluorescence during an operation can maximize safety during the cerebral glioblastoma resection, thus protecting brain function and improving surgical efficacy and patients’ postoperative quality of life.

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“…24 In our initial experience, 80 patients had total or near total resection, which represents a good resection range, comparable to or better than the 91% of total or near total resection reported thus far. 25 The rate of new neurological damage has been reported to be 18-23% has been reported. 26,27,28 In our study, 91% Here, a retrospective analysis was conducted on patients undergoing an awake craniotomy.…”

Section: Discussionmentioning

confidence: 99%

“…25 The rate of new neurological damage has been reported to be 18-23% has been reported. 26,27,28 In our study, 91% Here, a retrospective analysis was conducted on patients undergoing an awake craniotomy. Although the number of cases was limited, our results suggest the promising prospects for performing awake craniotomy to remove glioblastomas.…”

Section: Discussionmentioning

confidence: 99%

The effect of using awake craniotomy combined with multimodal techniques intraoperative on survival of patients with glioblastoma: a single-center experience

Yang¹,

Lu²,

Deng³

et al. 2020

Preprint

0

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Background:We analysed outcomes of cerebral glioblastoma patients undergoing awake craniotomies combined with multimodal techniques for tumour resection, with regards to the extent of resection, functional preservation, and prognosis.Methods:A retrospective analysis was conducted on adult glioblastoma patients who underwent an awake craniotomy from September 2010 to August 2018 under anaesthesia combined with multimodal techniques. Results:In total, 81 glioblastoma patient charts were analysed. The most common lesion sites were the frontal lobe (n=36), temporal lobe (n=17), and parietal lobe (n=6). The main symptoms were headache (n=51), dyskinesia (n=11), speech disorder (n=9), and epilepsy (n=10). The extent of resection was gross total for 91.36% patients, subtotal for 7.41%, and partial for 1.23%. No deaths occurred 30 days post-operation. Intracranial haemorrhage occurred in 2 patients, seizures in 5 patients, and intracranial infections in 3 patients. There was no significant difference between preoperative and postoperative Karnofsky Performance Status scores (P>0.05). There were no significant changes in postoperative neurological function in 50 patients. Symptoms improved in 24 patients. Three patients exhibited motor dysfunction, 2 exhibited speech deficits, and 2 exhibited sensory deficits. The average duration of hospitalization was 6.89±2.66 days. The shortest survival time was 4 months, the longest survival time was 26 months, and the median survival time was 12 months.Conclusions: Awake craniotomy using multimodal techniques such as neuronavigation, intraoperative ultrasound, electrophysiology, and tumour fluorescence during an operation can maximize safety during the cerebral glioblastoma resection, thus protecting brain function and improving surgical efficacy and patients’ postoperative quality of life.

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“…24 In our initial experience, 80 patients had total or near total resections, which represents a good resection range, comparable to or better than the 91% total or near total resection rate reported thus far. 25 The rate of new neurological damage has been reported to be 18-23%. 26,27,28 In our study, 91% of patients had either improved or no change in their neurological status.…”

Section: Discussionmentioning

confidence: 99%

“…25 The rate of new neurological damage has been reported to be 18-23%. 26,27,28 In our study, 91% of patients had either improved or no change in their neurological status. Only 7 patients experienced new neurological dysfunction and a reduced KPS score after surgery, including worsening of their pre-existing neurological dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The effect of using awake craniotomy combined with multimodal techniques intraoperatively on the survival of patients with glioblastoma: A retrospective single-centre study

Zhou¹,

Li²,

Lü³

et al. 2020

Preprint

2

0

View full text Add to dashboard Cite

Background :We analysed outcomes of cerebral glioblastoma patients undergoing awake craniotomies combined with multimodal techniques for tumour resection, with regards to the extent of resection, functional preservation, and prognosis. Methods : A retrospective analysis was conducted on adult glioblastoma patients who underwent an awake craniotomy from September 2010 to August 2018 under anaesthesia combined with multimodal techniques. Results: In total, 81 glioblastoma patient charts were analysed. The most common lesion sites were the frontal lobe (n=36), temporal lobe (n=17), and parietal lobe (n=6). The main symptoms were headache (n=51), dyskinesia (n=11), speech disorder (n=9), and epilepsy (n=10). The extent of resection was gross total for 91.36% patients, subtotal for 7.41%, and partial for 1.23%. No deaths occurred 30 days post-operation. Intracranial haemorrhage occurred in 2 patients, seizures in 5 patients, and intracranial infections in 3 patients. There was no significant difference between preoperative and postoperative Karnofsky Performance Status scores (P>0.05). There were no significant changes in postoperative neurological function in 50 patients. Symptoms improved in 24 patients. Three patients exhibited motor dysfunction, 2 exhibited speech deficits, and 2 exhibited sensory deficits. The average duration of hospitalization was 6.89±2.66 days. The shortest survival time was 4 months, the longest survival time was 26 months, and the median survival time was 12 months. Conclusions: Awake craniotomy using multimodal techniques such as neuronavigation, intraoperative ultrasound, electrophysiology, and tumour fluorescence during an operation can maximize safety during the cerebral glioblastoma resection, thus protecting brain function and improving surgical efficacy and patients’ postoperative quality of life.

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Clinical outcomes from maximum-safe resection of primary and metastatic brain tumors using awake craniotomy

Cited by 36 publications

References 35 publications

The effect of using awake craniotomy combined with multimodal techniques intraoperative on survival of patients with glioblastoma: a single-center experience

The effect of using awake craniotomy combined with multimodal techniques intraoperative on survival of patients with glioblastoma: a single-center experience

The effect of using awake craniotomy combined with multimodal techniques intraoperative on survival of patients with glioblastoma: a single-center experience

The effect of using awake craniotomy combined with multimodal techniques intraoperatively on the survival of patients with glioblastoma: A retrospective single-centre study

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