Clinical Outcomes Following Transcatheter Aortic Valve Replacement in Asian Population

Yoon, Sung‐Han; Ahn, Jung‐Min; Hayashida, Kentaro; Watanabe, Yusuke; Shirai, Shinichi; Kao, Hsien‐Li; Yin, Wei‐Hsian; Lee, Michael Kang-Yin; Tay, Edgar; Araki, Motoharu; Yamanaka, Futoshi; Arai, T.; Lin, Mao‐Shin; Park, Jun Bean; Park, Duk‐Woo; Kang, Soo–Jin; Lee, Seung-Whan; Kim, Young‐Hak; Lee, Cheol Whan; Park, Seong-Wook; Muramatsu, Toshiya; Hanyu, Michiya; Kozuma, Ken; Kim, Hyo–Soo; Saïto, Shigeru; Park, Seung‐Jung

doi:10.1016/j.jcin.2016.01.047

Cited by 71 publications

(64 citation statements)

References 31 publications

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“…We reported the mid-term results of our own modest series last year consisting of 59 patients who underwent TAVI procedure between 2010 and 2015 (22) Asian countries. The 30-day mortality in this cohort was 2.5% and the 1-year mortality was 10.8% (14).…”

Section: Discussionmentioning

confidence: 62%

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Transcatheter aortic valve implantation in Asia

Hon

Tay

2017

Ann. Cardiothorac. Surg.

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The use of transcatheter aortic valve implantation (TAVI) to treat severe symptomatic aortic valve stenosis has increased exponentially in the last decade. This rapid expansion was seen predominantly in Western developed nations and has been fuelled by favorable results reported from a plethora of well-publicized randomized controlled trials, large retrospective series and national registries. Now, TAVI has become the standard of care for inoperable patients and an alternative to open surgery in patients who are at intermediate to high risk for open surgery. Notwithstanding these positive results, Asia has been relatively slow to adopt this technology despite a potentially large patient pool. Unique features of Asian medical environments and differences in Asian anatomy affecting TAVI uptake in Asia will be discussed. This article serves to outline the various challenging aspects of disseminating TAVI in Asian countries.

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Section: Discussionmentioning

confidence: 62%

“…The Asian Pacific TAVR Multicentre Registry (NCT02195102) enrolls patients spanning eight Asian countries from at least 10 institutions and currently has more than 1,000 patients in this database. The Asian TAVR is a Korean initiative with more than 840 patients recruited from 11 institutions spanning five Asian countries (14).…”

Section: Registry and Trialsmentioning

confidence: 99%

Transcatheter aortic valve implantation in Asia

Hon

Tay

2017

Ann. Cardiothorac. Surg.

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“…Based on data from previous registries, the proportion of patients with bicuspid AS may reach 2% to 6% (14,15). As the indication of TAVR has been expanding to younger and lower surgical-risk patients with increasing frequency of bicuspid AS, there has been increasing concern regarding the clinical outcomes of TAVR in bicuspid AS population (7)(8)(9)(16)(17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes and prognostic factors of transcatheter aortic valve implantation in bicuspid aortic valve patients

Yoon¹,

Sharma²,

Chakravarty³

et al. 2017

Ann. Cardiothorac. Surg.

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“…Recently, a multicenter, large-scale TAVR study revealed that Asian populations had lower STS scores (5.2%), body mass index, 30-day and 1-year mortality (2.5 and 10.8%), but similar post-TAVR complications when compared to Western populations [19]. Our sample is a typical Asian population, albeit with a slightly higher STS score.…”

Section: Discussionmentioning

confidence: 70%

Predictors of Thrombocytopenia after Self-Expandable Transcatheter Aortic Valve Replacement: A Single-Center Experience from China

Zhu¹,

Liu²,

et al. 2018

Cardiology

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Objectives: The importance of thrombocytopenia (TP) has been discussed previously. However, data are still limited, especially on predictors of TP. We sought to investigate predictors of TP after transcatheter aortic valve replacement (TAVR), in particular, clinically significant TP. Methods: We reviewed a total of 123 consecutive patients undergoing TAVR in our medical center. They were stratified into 3 groups according to the nadir platelet count post-TAVR: no/mild TP, moderate TP, and severe TP. Clinically significant TP, also known as major TP, was defined as moderate-to-severe TP (a nadir platelet count <100 × 10⁹/L and a >50% decrease in platelet count). Results: Baseline platelet, baseline hemoglobin, general anesthesia (GA), valve malpositioning and post-TAVR left ventricular ejection fraction were found to be predictors of post-TAVR nadir platelet count. Major TP was associated with a higher risk of major bleeding (OR 3.524, 95% CI 1.546-8.031) and 1-month mortality (OR 11.226, 95% CI 1.208-104.328). Age (OR 1.110, 95% CI 1.014-1.215) and GA (OR 6.494, 95% CI 2.058-20.408) were predictors of major TP. Conclusion: Post-TAVR nadir platelet count can be predicted based on baseline and procedural data. Old age and GA contribute to clinically significant TP.

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Clinical Outcomes Following Transcatheter Aortic Valve Replacement in Asian Population

Abstract: Despite anatomical features of concern, the clinical outcomes of TAVR in our Asian population were favorable in comparison with those of previously published trials and observational studies. (The Asian Transcatheter Aortic Valve Replacement Registry [Asian TAVR]; NCT02308150).

Cited by 71 publications

References 31 publications

Transcatheter aortic valve implantation in Asia

Transcatheter aortic valve implantation in Asia

Clinical outcomes and prognostic factors of transcatheter aortic valve implantation in bicuspid aortic valve patients

Predictors of Thrombocytopenia after Self-Expandable Transcatheter Aortic Valve Replacement: A Single-Center Experience from China

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