2015
DOI: 10.1097/md.0000000000000500
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Clinical Outcomes and Quality of Life Following Surgical Treatment for Refractory Epilepsy

Abstract: Surgery for refractory epilepsy is widely used but the efficacy of this treatment for providing a seizure-free outcome and better quality of life remains unclear.This study aimed to update current evidence and to evaluate the effects of surgery on quality of life in patients with refractory epilepsy.A systematic review and meta-analysis of the literature were conducted and selected studies included 2 groups of refractory epilepsy patients, surgical and nonsurgical.The studies were assessed using the Newcastle–… Show more

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Cited by 34 publications
(38 citation statements)
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“…Moreover, many areas within the parietal lobe have critical functions (Kamali et al ., ; Kim et al ., ; Binder et al ., ). Based on previous studies, compared with temporal lobe epilepsy, success rates and seizure outcome for epilepsy surgery in drug‐resistant PLEs is less promising (Binder et al ., ; Harroud et al ., ; Liu et al ., ).…”
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confidence: 98%
“…Moreover, many areas within the parietal lobe have critical functions (Kamali et al ., ; Kim et al ., ; Binder et al ., ). Based on previous studies, compared with temporal lobe epilepsy, success rates and seizure outcome for epilepsy surgery in drug‐resistant PLEs is less promising (Binder et al ., ; Harroud et al ., ; Liu et al ., ).…”
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confidence: 98%
“…It is a well‐known fact that psychiatric morbidity in epilepsy is high, with reported lifetime prevalence rates of up to 50% . This comorbidity influences quality of life (QoL), even independent of seizures …”
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confidence: 99%
“…Patients with treatment‐refractory seizures are at a higher risk of developing psychiatric disorders . Surgery is proven to be the best therapeutic alternative for treating drug‐resistant epilepsy, leading to a seizure‐free outcome in about two thirds of patients and improving patients' QoL …”
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confidence: 99%
“…Patients who suffer from medically refractory partial‐onset epilepsy account for ~30% of all epilepsies (Brodie & Dichter, ; Liu et al, ). Standard of care surgical treatment options for this condition include resective surgery, vagal nerve stimulation (VNS), or, more recently, deep brain stimulation therapy (DBS, Medtronic, Minneapolis, MN), and responsive neurostimulation therapy (RNS, NeuroPace, Mountain View, CA) (Morrell, ).…”
Section: Introductionmentioning
confidence: 99%