Clinical outcomes and periodontal conditions of dental implants placed in free fibula flaps (FFF): a retrospective study with a mean follow-up of 6 years

Lombardo, Giorgio; D’Agostino, Antonio; Nocini, Pier Francesco; Signoriello, Annarita; Zangani, Alessandro; Pardo, Alessia; Lonardi, Fabio; Trevisiol, Lorenzo

doi:10.1007/s00784-023-05364-w

Cited by 4 publications

(2 citation statements)

References 72 publications

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“…Placing conventional dental implants of standard diameters and lengths often requires additional bone augmentation with predictable increases in treatment morbidity, time, and cost [34][35][36]. It has been reported that clinicians must emphasize to patients and caregivers to provide customized patient prosthetic accessibility for oral hygiene procedures [37].…”

Section: Discussionmentioning

confidence: 99%

Short and Extra Short Dental Implants in Osseous Microvascular Free Flaps: A Retrospective Case Series

Hocková,

Slávik,

Azar

et al. 2024

JPM

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There is limited information regarding implant and prosthetic survival after osseous microvascular free flap (OMFF). This case series aims to describe the placement of short and extra short implants in osseous microvascular free flaps to support prostheses, and present an up to 40-month retrospective follow-up. Short and extra short dental implants were placed in six fibula free flaps (FFF) and in two microvascular deep circumflex iliac artery (DCIA) flaps. In total, 27 short and extra short dental implants have been placed into two different types of free flaps. Kaplan–Meyer (K-M) survival analyses were performed to evaluate the survival and success outcomes of implants and prostheses. Out of the eight patients reconstructed with free flap, five were rehabilitated with prostheses, one patient has a temporary prosthesis, and two patients are in the process of prosthetic rehabilitation. Twenty-seven implants were followed up for up to 40 months, and K-M analyses showed 100% implant survival probability (95% confidence interval: 100%), while the implant success probability was 91.0% (95% confidence interval: 68.6–97.7%). Short and extra short dental implants placed in OMFF presented high survival and success rates in a retrospective case series after up to 40 months.

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Section: Discussionmentioning

confidence: 99%

Short and Extra Short Dental Implants in Osseous Microvascular Free Flaps: A Retrospective Case Series

Hocková,

Slávik,

Azar

et al. 2024

JPM

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show abstract

“…The current standard of care for reconstruction of defects involves surgical intervention utilizing autogenous bone grafts (autografts) due to their established osteoconductive, osteogenic, and osteoinductive properties [ 5 ]. This type of grafting has been used in a wide range of procedures, including alveolar distraction, dental implantation, and various head and neck procedures [ 6 , 7 , 8 ]. Autografts are harvested from various bones; however, the fibula is a common donor site due to its non-weight-bearing status [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review

Ehlen,

Mirsky,

Slavin

et al. 2024

IJMS

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Bone regeneration remains a significant clinical challenge, often necessitating surgical approaches when healing bone defects and fracture nonunions. Within this context, the modulation of adenosine signaling pathways has emerged as a promising therapeutic option, encouraging osteoblast activation and tempering osteoclast differentiation. A literature review of the PubMed database with relevant keywords was conducted. The search criteria involved in vitro or in vivo models, with clear methodological descriptions. Only studies that included the use of indirect adenosine agonists, looking at the effects of bone regeneration, were considered relevant according to the eligibility criteria. A total of 29 articles were identified which met the inclusion and exclusion criteria, and they were reviewed to highlight the preclinical translation of adenosine agonists. While preclinical studies demonstrate the therapeutic potential of adenosine signaling in bone regeneration, its clinical application remains unrealized, underscoring the need for further clinical trials. To date, only large, preclinical animal models using indirect adenosine agonists have been successful in stimulating bone regeneration. The adenosine receptors (A1, A2A, A2B, and A3) stimulate various pathways, inducing different cellular responses. Specifically, indirect adenosine agonists act to increase the extracellular concentration of adenosine, subsequently agonizing the respective adenosine receptors. The agonism of each receptor is dependent on its expression on the cell surface, the extracellular concentration of adenosine, and its affinity for adenosine. This comprehensive review analyzed the multitude of indirect agonists currently being studied preclinically for bone regeneration, discussing the mechanisms of each agonist, their cellular responses in vitro, and their effects on bone formation in vivo.

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Finite Element Assessment of a Novel Patient‐Specific Mandibular Implant for Severely Atrophic Ridge

Parhiz,

Nourishirazi,

Asadi

et al. 2024

BioMed Research International

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Purpose: Dental reconstruction for patients diagnosed with severe mandibular bone atrophy using common dental implants is a challenging process. In such cases, surgeons may encounter challenges such as insufficient available bone, soft tissue, damage to the inferior alveolar nerve, and even the risk of bone fracture. In this study, a new design concept of mandibular patient‐specific implants for severely atrophic ridges followed by finite element evaluation was presented to investigate the mechanical functionality of the concept.Method: The implant is comprised of two modular parts including an inferior border cover and a horseshoe‐shaped structure. This horseshoe segment fits into the cover and is then screwed to it using two screws on each side. A 1 mm deflection was applied to a reference point located between the two anterior posts to extract the resulting Von Mises stress distribution in each part and the reaction force on the reference point which corresponds to the chewing force that the patient must apply to deform the horseshoe. This 1 mm gap is a design consideration and critical distance that horseshoe contacts the gingiva and disturbs the alveolar nerve.Results: The results revealed that load was transmitted from the horseshoe to the cover, and there were no stress contours on the body of the mandible. However, stress concentration was observed in screw locations in the mandible, the amount of which was decreased by increasing the number of used screws. In horseshoe, stress concentration values were around 350 MPa, and the measured reaction force on the reference point was just under 200 N.Conclusion: The finite element analysis results showed that this concept would be functional as the minimum load would be transmitted to the mandibular ridge, and since the patients diagnosed with atrophic ridge are not able to apply load to an amount near 200 N, the horseshoe would not contact the gingiva. Also, it is concluded that increasing the number of bone screw fixations would decrease the risk of long‐term screw loosening.

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Clinical outcomes and periodontal conditions of dental implants placed in free fibula flaps (FFF): a retrospective study with a mean follow-up of 6 years

Cited by 4 publications

References 72 publications

Short and Extra Short Dental Implants in Osseous Microvascular Free Flaps: A Retrospective Case Series

Short and Extra Short Dental Implants in Osseous Microvascular Free Flaps: A Retrospective Case Series

Translational Experimental Basis of Indirect Adenosine Receptor Agonist Stimulation for Bone Regeneration: A Review

Finite Element Assessment of a Novel Patient‐Specific Mandibular Implant for Severely Atrophic Ridge

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