Clinical outcomes after transfer of blastocysts derived from frozen–thawed cleavage embryos: a retrospective propensity-matched cohort study

Xiong, Feng; Li, Guan-Gui; Sun, Qing; Wang, Sisi; Wan, Caiyun; Chen, Peilin; Yao, Zhihong; Zhong, Huixian; Zeng, Yong

doi:10.1007/s00404-019-05236-3

Cited by 13 publications

(6 citation statements)

References 42 publications

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“… CPR, MR, LBR, PR Wang 2005 [ 54 ] Infants conceived through ART procedures and born in Australia Any age 7676/3824 Retrospective cohort study 1996 to 2000 LBW. Wei 2019 [ 7 ] Women with regular menstrual cycles undergoing their first cycle of in-vitro fertilization 28.8 (3.0) / 28·8 (3.0) 825/825 RCT Aug 2016, to Jun 2017 R, CPR, MR, MPR, LBR, OPR, PR, EPR, PP, PH, PTD, GDM, PIH, LGA, SGA, NM Wennerholm 1997 [ 55 ] Birth after IVF with cryopreserved–thawed embryos in Sweden 34.0 ± 3.1/ 33.6 ± 3.3 209/209 Matched cohort study Jun1990 to Jul 1995 PH, PTD, GDM, PIH, LBW Wennerholm 2013 [ 56 ] Singletons conceived after FET in Denmark, Norway and Sweden 33.3 ± 4.0/33.7 ± 3.9 42,242/6647 Retrospective cohort study Until Dec 2007 PTD, LGA, SGA, VSGA, LBW, HBW, Wikland 2010 [ 57 ] Children born after vitrified BTor fresh BT 34.7 (22.0–44.0)/35.4 (26.3–45.3) 203/103 Retrospective cohort study Jan 2006 to May 2008 MR, LBR, PR, EPR, PP, PA, GDM, PIH, LGA, SGA, LBW, Wu 2014 [ 58 ] High responder patients diagnosed as primary infertility with more than 15 oocytes retrieved 29.02 ± 2.87/ 29.05 ± 2.48 50/69 Retrospective cohort study Jan to Nov 2012 IR, CPR, MPR, Wu 2019 [ 59 ] Patients with advanced endometriosis undergoing first embryo transfer cycles No statement 255/ 506 Retrospective cohort study Mar 2006 to Mar 2017 IR, CPR, MR, EPR, LBR, PTD, VPTD, LBW, VLBW Xiong 2019 [ 60 ] Women who underwent fresh or frozen ET 33.39 ± 3.75 /34.07 ± 4.14 101/ 179 Retrospective cohort study. Aug 2014 to Jul 2017.…”

Section: Resultsmentioning

confidence: 99%

Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?

Yang

Sha

et al. 2020

BMC Pregnancy Childbirth

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Background In recent years, there have been many reports on the pregnancy outcomes of fresh blastocyst transfer (BT) and frozen-thawed BT, but the conclusions are controversial and incomplete. To compare the pregnancy outcomes, maternal complications and neonatal outcomes of fresh and frozen-thawed BT in the context of in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) cycles, we conducted a meta-analysis. Methods A meta-analysis was conducted by searching the PubMed, Embase, and Cochrane Library databases through May 2020. Data were extracted independently by two authors. Results Fifty-four studies, including 12 randomized controlled trials (RCTs), met the inclusion criteria. Fresh BT was associated with a lower implantation rate, pregnancy rate, ongoing pregnancy rate, and clinical pregnancy rate and higher ectopic pregnancy rate than frozen-thawed BT according to the results of the RCTs. The risks of moderate or severe ovarian hyperstimulation syndrome, placental abruption, placenta previa and preterm delivery were higher for fresh BT than for frozen-thawed BT. The risk of pregnancy-induced hypertension and pre-eclampsia was lower for fresh BT; however, no significant differences in risks for gestational diabetes mellitus and preterm rupture of membrane were found between the two groups. Compared with frozen-thawed BT, fresh BT appears to be associated with small for gestational age and low birth weight. No differences in the incidences of neonatal mortality or neonatal malformation were observed between fresh and frozen-thawed BT. Conclusions At present there is an overall slight preponderance of risks in fresh cycles against frozen, however individualization is required and current knowledge does not permit to address a defintive response.

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Section: Resultsmentioning

confidence: 99%

Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?

Yang

Sha

et al. 2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

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“…Insemination of mature oocytes was performed by conventional IVF or ICSI according to the sperm parameters. Details on embryo culture, vitri cation, thawing and transfer procedures have been described in our previous studies [13,14]. Embryos on Day 3 were graded according to the morphology criteria [15].…”

Section: Methodsmentioning

confidence: 99%

Hormone Replacement Therapy With GnRH Agonist Pretreatment Improves Pregnancy Outcomes in Patients With Previous Intrauterine Adhesions: a Retrospective Study

Zheng

Zhang

et al. 2021

Preprint

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Objective: This retrospective study aimed to explore the optimal endometrial preparation method in women with intrauterine adhesions (IUAs).Method: A total of 882 frozen-thawed embryo transfer (FET) cycles from patients with history of IUAs were categorized into three groups based on endometrial preparation methods: hormone replacing therapy cycle (HRT, n=636), natural cycle (NC n=174), and HRT with GnRH-a pretreatment (HRT+GnRH-a, n=72. Logistic regression was performed to investigate the association between cycle regimens and pregnancy outcomes. Subgroup analysis of IUAs combined with thin endometrium (≤7mm) was also performed.Results: HRT with GnRH-a pretreatment was associated with higher incidences of clinical pregnancy, ongoing pregnancy, and live birth, but lower early miscarriage compared with either HRT or NC. Logistic regression indicated that after controlling for potential confounders, the incidences of live birth (HRT+GnRH-a as reference; NC: aOR=0.577, 95%CI 0.304-1.093; HRT: aOR=0.434, 95%CI 0.247-0.765) and ongoing pregnancy (NC: aOR=0.614, 95%CI 0.324-1.165; HRT: aOR=0.470, 95%CI 0.267-0.829) remained significantly higher in HRT+GnRH-a compared to those in HRT, but comparable to those in NC. While there was no significant difference with respect to the clinical pregnancy rate (NC: aOR=0.695, 95%CI 0.374-1.291; HRT: aOR=0.650, 95%CI 0.374-1.127) and early miscarriage rate (NC: aOR=1.734, 95%CI 0.417-7.175; HRT: aOR=2.594, 95%CI 0.718-9.378) between groups. Subgroup analysis suggested there was no superiority of endometrial preparation method in IUAs combined with thin endometrium.Conclusion: HRT with GnRH-a pretreatment improves pregnancy outcomes in women with history of IUAs. GnRH-a may restore the endometrial receptivity in the FET cycles in IUAs.

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“…Insemination of mature oocytes was performed by conventional IVF or ICSI according to the sperm parameters. Details on embryo culture, vitri cation, thawing and transfer procedures have been described in our previous studies [11,12]. Embryos on Day 3 were graded according to the morphology criteria [13].…”

Section: Methodsmentioning

confidence: 99%

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy improves pregnancy outcome in intrauterine adhesion

Mo¹,

Zheng²,

Zhang³

et al. 2021

Preprint

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Objective: This retrospective study aimed to explore the optimal endometrial preparation method in women with intrauterine adhesions (IUAs).Method: A total of 882 frozen-thawed embryo transfer (FET) cycles were categorized into three groups based on endometrial preparation methods: hormone replacing therapy cycle (HRT, n=636), natural cycle (NC n=174), and HRT with GnRH-a pretreatment (HRT+GnRH-a, n=72. Logistic regression was performed to investigate the association between cycle regimens and pregnancy outcomes. Subgroup analysis of IUAs combined with thin endometrium (≤7mm) was also performed.Results: HRT with GnRH-a pretreatment was associated with higher incidences of clinical pregnancy, ongoing pregnancy, and live birth, but lower early miscarriage compared with either HRT or NC. Logistic regression indicated that after controlling for potential confounders, the incidences of live birth (HRT+GnRH-a as reference; NC: aOR=0.577, 95%CI 0.304-1.093; HRT: aOR=0.434, 95%CI 0.247-0.765) and ongoing pregnancy (NC: aOR=0.614, 95%CI 0.324-1.165; HRT: aOR=0.470, 95%CI 0.267-0.829) remained significantly higher in HRT+GnRH-a compared to those in HRT, but comparable to those in NC. While there was no significant difference with respect to the clinical pregnancy rate (NC: aOR=0.695, 95%CI 0.374-1.291; HRT: aOR=0.650, 95%CI 0.374-1.127) and early miscarriage rate (NC: aOR=1.734, 95%CI 0.417-7.175; HRT: aOR=2.594, 95%CI 0.718-9.378) between groups. Subgroup analysis suggested there was no priority of endometrial preparation method in IUAs combined with thin endometrium.Conclusion: HRT with GnRH-a pretreatment improves pregnancy outcomes in women with history of IUAs. GnRH-a may restore the endometrial receptivity in the FET cycles in IUAs.

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Clinical outcomes after transfer of blastocysts derived from frozen–thawed cleavage embryos: a retrospective propensity-matched cohort study

Cited by 13 publications

References 42 publications

Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?

Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer?

Hormone Replacement Therapy With GnRH Agonist Pretreatment Improves Pregnancy Outcomes in Patients With Previous Intrauterine Adhesions: a Retrospective Study

Gonadotropin-releasing hormone agonist combined with hormone replacement therapy improves pregnancy outcome in intrauterine adhesion

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